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CTSL2

Official Full Name

Cathepsin L2
Overview

Cathepsin V, also known as Cathepsin L2, is a 334 amino acid protein that belongs to the peptidase C1 family and is found in the lysosome. It is a Cysteine protease that may have an important role in corneal physiology. It can also function as a hydrolase and thiol protease. The recombinant enzyme hydrolyzes proteins (serum albumin, collagen) and synthetic substrates (Z-Phe-Arg-NHMec > Z-Leu-Arg-NHMec > Z-Val-Arg-NHMec). Cathepsin V is expressed predominantly in the thymus and testis. It is also expressed in corneal epithelium, and to a lesser extent in conjunctival epithelium and skin.
Synonyms

UNQ268/PRO305; CATL2; CTSU; CTSV; cathepsin L2, preproprotein; cathepsin U; cathepsin V;

Type

Recombinant Proteins
Cell & Tissue Lysates
Protein Pre-coupled Magnetic Beads

Species

Chicken
Human

Source

Free Style 293-F Cell
HEK293
Human Cell
Insect Cell
Mammalian Cell
Mammalian cells

Tag

His
His (Fc)
Avi
N/A

Species	Cat.#	Product name	Source (Host)	Tag	Price
Human	CTSL2-507H	Recombinant Human Cathepsin L2, His-tagged	Free Style 293-F Cell	His	Inquiry
Human	CTSL2-751H	Recombinant Human Cathepsin L2, His-tagged	Mammalian cells	His	Inquiry
Human	CTSL2-614H	Recombinant Human CTSL2, His tagged	Human Cell	His	$623 / 10 µg
Human	CTSL2-681H	Recombinant Human Cathepsin L2, His-tagged	Insect Cell	His	Inquiry
Human	CTSL2-7191HCL	Recombinant Human CTSL2 293 Cell Lysate	HEK293	N/A	Inquiry
Human	CTSL2-2755H-B	Recombinant Human CTSL2 Protein Pre-coupled Magnetic Beads	HEK293		Inquiry
Human	CTSL2-2755H	Recombinant Human CTSL2 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi	Inquiry
Chicken	CTSL2-4041C	Recombinant Chicken CTSL2	Mammalian Cell	His	Inquiry

Involved Pathway
Protein Function
Interacting Protein
CTSL2 Related Research Area

CTSL2 involved in several pathways and played different roles in them. We selected most pathways CTSL2 participated on our site, such as Activation of Matrix Metalloproteinases, Adaptive Immune System, Antigen processing-Cross presentation, which may be useful for your reference. Also, other proteins which involved in the same pathway with CTSL2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Activation of Matrix Metalloproteinases	ELANE;MMP11;TPSAB1;LOC100686744;MMP17;CTRB1;TIMP2A;CMA1;CTSLL
Adaptive Immune System	SEC24A;CTSS;ASB6;DCTN3;FGF18B;CD200;FBXO3;RNF138;ASB14
Antigen processing-Cross presentation	FCGR1B;SEC61B;CTSL2;CTSL1;CYBA;CTSS;CYBB;CD207
Assembly of collagen fibrils and other multimeric structures	CTSS;COL2A1;LOXL2;COL6A1;ABHD1;COL4A6;BMP1B;CD151;PLEC
Class I MHC mediated antigen processing &amp	RNF111;ASB10;RNF25;LRSAM1;RNF4;MKRN1;LRR1;LTN1;SEC61B
presentation	SPSB4;LRR1;TRAF7;UBE2U;CTSL1;RNF123;FBXO17;UBE2V2;TRIM41
Collagen formation	COL10A1;CTSB;BMP1;COL9A1A;COL9A3;COL9A1;TLL2;PPIB;TLDC2
Degradation of the extracellular matrix	ADAMTS18;MMP8;TIMP2B;EMID2;CTS7;FURINB;MMP24;MMP17;ACAN
Endochondral Ossification	FRZB;NKX3.2;CST5;RUNX3;CDKN1C;KIF3A;ADAMTS5;PTH;ADAMTS4

CTSL2 has several biochemical functions, for example, aminopeptidase activity, cysteine-type carboxypeptidase activity, cysteine-type endopeptidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CTSL2 itself. We selected most functions CTSL2 had, and list some proteins which have the same functions with CTSL2. You can find most of the proteins on our site.

Function	Related Protein
aminopeptidase activity	RNPEP;Npepo;LNPEP;BLMH;XPNPEP3;LTA4H;METAP1;CTSL2;XPNPEP2
cysteine-type carboxypeptidase activity	Ctsl;CTSL2
cysteine-type endopeptidase activity	USP17L5;USP48;USP34;USP42;USP20;USP25;CTSL1;USP1;CTSC
cysteine-type peptidase activity	OTUD7A;CASP8;BLMH;ALG13;CTSH;CTSL1B;CAPN2B;OTULIN;CASPC
histone binding	HIST1H4J;CD1d1;UIMC1;BRD1;IPO7;RAG1;HINFP;HIST1H3I;SIRT1
kininogen binding	C1QBP;CTSB;Ctsl;CTSL2
peptide binding	CALR;GPR37;RNPEP;OXTR;NUP98;ANPEP;CRIP1;GPR37L1;MAS1
protein binding	PPP1R12A;EFS;TRIP6;SRGN;NUDT22;DKK1B;KRTAP9-4;FLT1;SCO2
protein complex binding	NASP;PRMT5;YWHAB;GNB4;NCKAP1L;PPP4C;CAPG;HTR2A;ULK1

CTSL2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CTSL2 here. Most of them are supplied by our site. Hope this information will be useful for your research of CTSL2.

srp-6; BUB1; RB1; SRC; BRAF; APC; CTNNA1; BMPR1A; MLH1; DCC; PDGFRL; CDKN2A; DLC1; MLH3

Lysosomal Enzymes