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CBX5

  • Official Full Name

    chromobox homolog 5

  • Overview

    This gene encodes a highly conserved nonhistone protein, which is a member of the heterochromatin protein family. The protein is enriched in the heterochromatin and associated with centromeres. The protein has a single N-terminal chromodomain which can bind to histone proteins via methylated lysine residues, and a C-terminal chromo shadow-domain (CSD) which is responsible for the homodimerization and interaction with a number of chromatin-associated nonhistone proteins. The encoded product is involved in the formation of functional kinetochore through interaction with essential kinetochore proteins. The gene has a pseudogene located on chromosome 3. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jul 2008]
  • Synonyms

    CBX5; chromobox homolog 5; HP1; HP1A; HEL25; chromobox protein homolog 5; HP1-ALPHA; HP1Hs alpha; antigen p25; HP1 alpha homolog; epididymis luminal protein 25; heterochromatin protein 1-alpha; heterochromatin protein 1 homolog alpha; chromobox homolog 5 (HP1 alpha homolog, Drosophila);

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rhesus Macaque
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Mammalian Cell
  • Mammalian cells
  • Wheat Germ
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • MYC
  • N/A
  • T7|His
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human CBX5-27763TH Recombinant Human CBX5, His-tagged E.coli His
Human CBX5-154H Recombinant Human CBX5 protein, T7/His-tagged E.coli T7/His
Human CBX5-0483H Recombinant Human CBX5 Protein, GST-Tagged Wheat Germ GST
Human CBX5-7802HCL Recombinant Human CBX5 293 Cell Lysate HEK293 N/A
Human CBX5-32H Recombinant Human CBX5 Protein, MYC/DDK-tagged HEK293T Myc/DDK
Human CBX5-1781H Recombinant Human CBX5 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human CBX5-1112H Recombinant Human CBX5 protein, His&Myc-tagged E.coli His&Myc 1-191aa
Human CBX5-2781HF Recombinant Full Length Human CBX5 Protein, GST-tagged In Vitro Cell Free System GST 191 amino acids
Human CBX5-516H-B Recombinant Human CBX5 Protein Pre-coupled Magnetic Beads HEK293
Human CBX5-3435H Recombinant Human CBX5 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human CBX5-2036HFL Recombinant Full Length Human CBX5 Protein, C-Flag-tagged Mammalian cells Flag
Human CBX5-516H Recombinant Human CBX5 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse CBX5-2795M Recombinant Mouse CBX5 Protein Mammalian Cell His
Mouse Cbx5-794M Recombinant Mouse Cbx5 Protein, MYC/DDK-tagged HEK293T MYC/DDK
Mouse CBX5-1272M Recombinant Mouse CBX5 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse CBX5-1272M-B Recombinant Mouse CBX5 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque CBX5-648R Recombinant Rhesus monkey CBX5 Protein, His-tagged Mammalian Cell His
Rhesus Macaque CBX5-476R-B Recombinant Rhesus Macaque CBX5 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque CBX5-476R Recombinant Rhesus Macaque CBX5 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Zebrafish CBX5-5041Z Recombinant Zebrafish CBX5 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein

CBX5 involved in several pathways and played different roles in them. We selected most pathways CBX5 participated on our site, such as Aurora B signaling, E2F transcription factor network, Factors involved in megakaryocyte development and platelet production, which may be useful for your reference. Also, other proteins which involved in the same pathway with CBX5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Aurora B signalingSGOL1;KIF20A;PEBP1;CENPA;NCAPD2;DES;EVI5;NPM1;KIF2C
E2F transcription factor networkHIC1;CDKN2C;MYBL2;CES3;HBP1;SMARCA2;CES1;E2F4;DHFR
Factors involved in megakaryocyte development and platelet productionGATA5;BA2;PHF21A;DOCK1;NFE2;DOCK8;GATA6;DOCK2;KLC3
HemostasisANXA2B;HMG20B;MYB;ANXA2;RACGAP1;SERPINF2B;SLC7A6;HBBE3;PLEK

CBX5 has several biochemical functions, for example, chromatin binding, histone deacetylase binding, methylated histone binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CBX5 itself. We selected most functions CBX5 had, and list some proteins which have the same functions with CBX5. You can find most of the proteins on our site.

Function Related Protein
chromatin bindingGM606;FABP1;ELK1;COQ7;DNMT3B;C19orf40;YBX1;ARX;ESR1
histone deacetylase bindingMAGEA1;NR2E1;DNMT3B;PRDM1;TAL1;SUDS3;HIC1;CEBPB;YY1
methylated histone bindingWDR92;PHF19;SPIN1;RBBP5;ING4;MPHOSPH8;PHF1;ZMYND11;ATRX
protein bindingTBC1D7;RSPH1;LURAP1;NDRG4;IFT46;MED10;LSM7;CIB2;LILRB4
protein binding, bridgingTRIM22;FRMD4A;EVPL;CRADD;FSCN1;MMS19;CSTA;CNKSR1;SYNM
protein homodimerization activityFASN;RXRB;GOT2;HOMER2;SUMF1;TCF3;GSTZ1;WHRN;PDK2
repressing transcription factor bindingHDAC9;TLE4;CTBP1;EIF4E;TBP;MYC;NOC2L;MAGEA2;HMGB1

CBX5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CBX5 here. Most of them are supplied by our site. Hope this information will be useful for your research of CBX5.

TRIM28; HIST1H3D; CHAF1A

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