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CBX8

Official Full Name

chromobox homolog 8
Overview

The family of Heterochromatin Proteins ("Chromobox Homolog", CBX) are highly conserved adapter molecules,Which have important functions in the cell nucleus. These functions include gene repression by heterochromatin formation, transcriptional activation, regulation of binding of cohesion complexes to centromere, sequesteration of genes to nuclear periphery, transcriptional arrest, maintenance of heterochromatin integrity, gene repression at single nucleosome level and gene repression by heterochromatization of euchromatin.
Synonyms

CBX8; chromobox homolog 8; chromobox homolog 8 (Drosophila Pc class); chromobox protein homolog 8; HPC3; Pc class 3 homolog (Drosophila); PC3; polycomb 3; RC1; rectachrome 1; Pc class 3 homolog; chromobox homolog 8 (Pc class homolog, Drosophila);

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	CBX8-0486H	Recombinant Human CBX8 Protein, GST-Tagged	Wheat Germ	GST		Inquiry
Human	CBX8-7800HCL	Recombinant Human CBX8 293 Cell Lysate	HEK293	N/A		Inquiry
Human	CBX8-371H	Recombinant Human CBX8 protein, His&Myc-tagged	E.coli	His&Myc	1-389aa	Inquiry
Human	CBX8-2784HF	Recombinant Full Length Human CBX8 Protein, GST-tagged	In Vitro Cell Free System	GST	389 amino acids	Inquiry

Involved Pathway
Protein Function
Interacting Protein

CBX8 involved in several pathways and played different roles in them. We selected most pathways CBX8 participated on our site, such as Cellular Senescence, Cellular responses to stress, Metabolism of proteins, which may be useful for your reference. Also, other proteins which involved in the same pathway with CBX8 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Cellular Senescence	EED;CDKN2A;HIST3H2BB;EP400;ERF;SUZ12A;PHC2;BMI1A;PHC1
Cellular responses to stress	BAG3;EPAS1B;HIST3H2BB;HMGA1;RPS19BP1;MOV10;KAT5;HIST4H4;ATG4A
Metabolism of proteins	B3GNT3;NSMCE1;CALCA;MTX2;GALNTL2;TRAPPC4;APCS;INHBAA;GCNT3
Oxidative Stress Induced Senescence	SUZ12A;CBX8;RNF2;CBX8A;SUZ12;PHC2;MINK1;BMI1B;CBX8B
Post-translational protein modification	ST8SIA3;PPP6C;ARSD;SLC35A1;MUC20;NAPG;NEU3;TRAPPC5;SSPO
SUMO E3 ligases SUMOylate target proteins	CBX8;CBX4;NSMCE1;RNF2;PHC1;NSMCE2;SCMH1;PHC2;RING1
SUMOylation	EID3;SAE1;SCMH1;NSMCE2;SENP1;UBA2;NSMCE4A;PHC3;SENP5
SUMOylation of DNA damage response and repair proteins	PHC3;SMC5;NSMCE4A;SMC6;PHC2;PHC1;SCMH1;NSMCE1;RNF2

CBX8 has several biochemical functions, for example, methylated histone binding, protein binding, single-stranded RNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CBX8 itself. We selected most functions CBX8 had, and list some proteins which have the same functions with CBX8. You can find most of the proteins on our site.

Function	Related Protein
methylated histone binding	RBBP5;CHD8;UHRF1;KAT8;TP53BP1;RAG2;ING2;L3MBTL1;MSL3
protein binding	CLIC1;PGK1;PHF7;POU3F3;DBNDD2;BCL2L14;RPS6KB1;ERLIN1;SMG5
single-stranded RNA binding	AGO2;ENDOV;HMGB1;AGO1;POLR2GL;CBX8;EIF2C3;CBX7;CBX6
ubiquitin-protein transferase activator activity	FBXW7;UBE2L3;RING1;CBX8;AUP1

CBX8 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CBX8 here. Most of them are supplied by our site. Hope this information will be useful for your research of CBX8.

BMI1; RNF2