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CCM2

  • Official Full Name

    cerebral cavernous malformation 2

  • Overview

    This gene encodes a scaffold protein that functions in the stress-activated p38 Mitogen-activated protein kinase (MAPK) signaling cascade. The protein interacts with SMAD specific E3 ubiquitin protein ligase 1 (also known as SMURF1) via a phosphotyrosine binding domain to promote RhoA degradation. The protein is required for normal cytoskeletal structure, cell-cell interactions, and lumen formation in endothelial cells. Mutations in this gene result in cerebral cavernous malformations. Multiple transcript variants encoding different isoforms have been found for this gene.
  • Synonyms

    CCM2; cerebral cavernous malformation 2; C7orf22, chromosome 7 open reading frame 22; malcavernin; MGC4607; C7orf22; CCM2_HUMAN; Cerebral cavernous malformations 2 protein; MGC4067; MGC74868; OTTHUMP00000159554; OTTHUMP00000214270; OTTHUMP00000214271; OTTHUMP00000214273; PP10187; OSM;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Rhesus Macaque
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human CCM2-2496H Recombinant human CCM2, His-tagged E.coli His
Human CCM2-0645H Recombinant Human CCM2 Protein, GST-Tagged Wheat Germ GST
Human CCM2-7719HCL Recombinant Human CCM2 293 Cell Lysate HEK293 N/A
Human CCM2-2956HF Recombinant Full Length Human CCM2 Protein, GST-tagged In Vitro Cell Free System GST 444 amino acids
Human CCM2-3975H Recombinant Human CCM2 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Mouse Ccm2-2045M Recombinant Mouse Ccm2 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Rhesus Macaque CCM2-695R Recombinant Rhesus monkey CCM2 Protein, His-tagged Mammalian Cell His
Rhesus Macaque CCM2-523R Recombinant Rhesus Macaque CCM2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque CCM2-523R-B Recombinant Rhesus Macaque CCM2 Protein Pre-coupled Magnetic Beads HEK293
Zebrafish CCM2-464Z Recombinant Zebrafish CCM2 Mammalian Cell His
Chicken CCM2-4167C Recombinant Chicken CCM2 Mammalian Cell His
  • CCM2 Related Articles

CCM2 involved in several pathways and played different roles in them. We selected most pathways CCM2 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with CCM2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein

CCM2 has several biochemical functions, for example, . Some of the functions are cooperated with other proteins, some of the functions could acted by CCM2 itself. We selected most functions CCM2 had, and list some proteins which have the same functions with CCM2. You can find most of the proteins on our site.

Function Related Protein

CCM2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CCM2 here. Most of them are supplied by our site. Hope this information will be useful for your research of CCM2.

Tanriover, G; Sozen, B; et al. Ultrastructural analysis of vascular features in cerebral cavernous malformations. CLINICAL NEUROLOGY AND NEUROSURGERY 115:438-444(2013).
Tanriover, G; Boylan, AJ; et al. PDCD10, the gene mutated in cerebral cavernous malformation 3, is expressed in the neurovascular unit. NEUROSURGERY 62:930-938(2008).
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