CCNK
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Official Full Name
cyclin K
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Overview
The protein encoded by this gene is a member of the transcription cyclin family. These cyclins may regulate transcription through their association with and activation of cyclin-dependent kinases (CDK) that phosphorylate the C-terminal domain (CTD) of the large subunit of RNA polymerase II. This gene product may play a dual role in regulating CDK and RNA polymerase II activities. -
Synonyms
CCNK; cyclin K; cyclin-K; CPR4; CCNK_HUMAN; CPR 4; CyclinK; MGC9113; OTTHUMP00000246203; OTTHUMP00000246205;
- Recombinant Proteins
- Cell & Tissue Lysates
- Chicken
- Human
- Mouse
- Zebrafish
- E. coli
- HEK293
- HEK293T
- In Vitro Cell Free System
- Insect Cell
- Mammalian Cell
- Sf9 Insect Cell
- Wheat Germ
- C
- His
- GST
- MYC
- DDK
- Myc|DDK
- N/A
- N
| Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| Human | CCNK-0677H | Recombinant Human CCNK Protein, GST-Tagged | Wheat Germ | GST |
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| Human | CCNK-6981H | Recombinant Human CyclinK, GST-tagged | Sf9 Insect Cell | GST | Full length |
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| Human | CCNK-306HCL | Recombinant Human CCNK cell lysate | N/A |
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| Human | CCNK-10H | Recombinant Human CCNK Protein(1-354 aa), His-tagged | E. coli | N-His | 1-354 aa |
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| Human | CCNK-2980HF | Recombinant Full Length Human CCNK Protein, GST-tagged | In Vitro Cell Free System | GST | 354 amino acids |
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| Human | CCNK-2207H | Recombinant Human CCNK protein, His-tagged | Insect Cell | His | 1-354aa |
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| Human | CCNK-2979H | Recombinant Human CCNK Protein, MYC/DDK-tagged | HEK293 | Myc/DDK |
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| Human | CCNK-11H | Recombinant Human CCNK Protein(251-370 aa),, His-tagged | E. coli | C-His | 251-370 aa |
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| Mouse | Ccnk-801M | Recombinant Mouse Ccnk Protein, MYC/DDK-tagged | HEK293T | MYC/DDK |
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| Zebrafish | CCNK-7557Z | Recombinant Zebrafish CCNK | Mammalian Cell | His |
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| Chicken | CCNK-2872C | Recombinant Chicken CCNK | Mammalian Cell | His |
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- Involved Pathway
- Protein Function
- Interacting Protein
- CCNK Related Articles
CCNK involved in several pathways and played different roles in them. We selected most pathways CCNK participated on our site, such as Direct p53 effectors, which may be useful for your reference. Also, other proteins which involved in the same pathway with CCNK were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Direct p53 effectors | ARID3A;ZNF385A;DDX5;DDB2;SCN3B;DUSP1;DGCR8;PLK3;GADD45A |
CCNK has several biochemical functions, for example, RNA polymerase II carboxy-terminal domain kinase activity, cyclin-dependent protein serine/threonine kinase activity, cyclin-dependent protein serine/threonine kinase regulator activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CCNK itself. We selected most functions CCNK had, and list some proteins which have the same functions with CCNK. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| RNA polymerase II carboxy-terminal domain kinase activity | CDK8;MAPK1;CDK9;CDK7;CDK12;CDK1;CCNK;CDK13 |
| cyclin-dependent protein serine/threonine kinase activity | CDK8;CCNK;CDKL3;CDK20;CDK17;CDK14;CDK16;PFTK1;CDK5R1 |
| cyclin-dependent protein serine/threonine kinase regulator activity | CCNC;CCNL1A;CCNT1;CCNE1;PSTPIP2;CCNL1B;CCND1;CCNT2A;CCNK |
| protein binding | TTK;OAZ2;FAM65B;GAPDH;SRMS;SERPINB1A;CHCHD2;INIP;KDM5B |
| protein kinase binding | CD226;TP73;TUBB3;CCNB3;STX1B;TNNI3;TBC1D14;FAM83D;RB1CC1 |
CCNK has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CCNK here. Most of them are supplied by our site. Hope this information will be useful for your research of CCNK.
RBPMS; BHLHE40; NDC80; AES; LZTS2; ATXN1; FKBP6; STX11
- Q&As
- Reviews
Q&As (7)
Ask a questionCCNK is relevant in the G1 and S phases of the cell cycle.
It forms complexes with CDKs, influencing their activity.
Genetic alterations in CCNK are associated with some cancers and other diseases.
Dysregulated CCNK activity is linked to various cancers.
Strategies include developing inhibitors or modulators of CCNK for cancer therapy.
CCNK regulates cell cycle progression and transcription.
It plays a role in RNA Polymerase II-mediated transcription.
Customer Reviews (3)
Write a reviewGreat in protein studies.
Reliable, quick delivery.
Very satisfied, excellent quality.
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