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CCNT1

Official Full Name

cyclin T1
Overview

The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin tightly associates with CDK9 kinase, and was found to be a major subunit of the transcription elongation factor p-TEFb. The kinase complex containing this cyclin and the elongation factor can interact with, and act as a cofactor of human immunodeficiency virus type 1 (HIV-1) Tat protein, and was shown to be both necessary and sufficient for full activation of viral transcription. This cyclin and its kinase partner were also found to be involved in the phosphorylation and regulation of the carboxy-terminal domain (CTD) of the largest RNA polymerase II subunit.
Synonyms

CCNT1; cyclin T1; HIVE1, human immunodeficiency virus type 1 (HIV 1) expression (elevated) 1; cyclin-T1; CCNT; CYCT1; cyclin-T; cyclin T1b; cyclin C-related protein; CDK9-associated C-type protein; Human immunodeficiency virus-1 expression; subunit of po;

Type

Recombinant Proteins
Cell & Tissue Lysates
Protein Pre-coupled Magnetic Beads

Species

Human
Mouse
Zebrafish

Source

HEK293
In Vitro Cell Free System
Mammalian Cell
Wheat Germ

Tag

GST
His
His (Fc)
Avi
N/A

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	CCNT1-0680H	Recombinant Human CCNT1 Protein, GST-Tagged	Wheat Germ	GST		Inquiry
Human	CCNT1-308HCL	Recombinant Human CCNT1 cell lysate		N/A		Inquiry
Human	CCNT1-2994HF	Recombinant Full Length Human CCNT1 Protein, GST-tagged	In Vitro Cell Free System	GST	726 amino acids	Inquiry
Mouse	CCNT1-3005M	Recombinant Mouse CCNT1 Protein	Mammalian Cell	His		Inquiry
Mouse	CCNT1-1415M-B	Recombinant Mouse CCNT1 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Mouse	CCNT1-1415M	Recombinant Mouse CCNT1 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Zebrafish	CCNT1-8168Z	Recombinant Zebrafish CCNT1	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein

CCNT1 involved in several pathways and played different roles in them. We selected most pathways CCNT1 participated on our site, such as Transcriptional misregulation in cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with CCNT1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Transcriptional misregulation in cancer	DOT1L;MEIS1;WNT16;SIN3A;CEBPE;IL3;ZBTB16;HIST3H3;FLI1

CCNT1 has several biochemical functions, for example, DNA binding, chromatin binding, cyclin-dependent protein serine/threonine kinase regulator activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CCNT1 itself. We selected most functions CCNT1 had, and list some proteins which have the same functions with CCNT1. You can find most of the proteins on our site.

Function	Related Protein
DNA binding	DLX4B;BACH1A;MYCS;BLZF1;FUS;THAP11;ZFP82;ARHGEF38;TFDP1
chromatin binding	PRKCB;SOX15;HMGB2;RERE;UPF1;ATXN7;TDRD3;SMC1A;ELK1
cyclin-dependent protein serine/threonine kinase regulator activity	CCNL1B;CCNL1A;CKS1B;CCND1;CCNT2B;FAM58A;CCNY;CCNL1;CCNE1
protein binding	RTN4R;SERP1;ATG3;IFITM1;SERPINF2;TMED5;PLEC;TRIM55;ATP5B
snRNA binding	SNRNP35;RBPMS;HEXIM1;HEXIM2;CCNT1;CDK9;NCBP2
transcription regulatory region DNA binding	SMAD7;SALL3;CREB3L2;BCL11AA;NCOR1;PRDM5;DDIT3;ATF6B;HNRNPL

CCNT1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CCNT1 here. Most of them are supplied by our site. Hope this information will be useful for your research of CCNT1.

CDK9; AFF4; HEXIM1