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CD1D

  • Official Full Name

    CD1d molecule

  • Overview

    This gene encodes a divergent member of the CD1 family of transmembrane glycoproteins, which are structurally related;to the major histocompatibility complex (MHC) proteins and form heterodimers with beta-2-microglobulin. The CD1;proteins mediate the presentation of primarily lipid and glycolipid antigens of self or microbial origin to T cells.;The human genome contains five CD1 family genes organized in a cluster on chromosome 1. The CD1 family members are;thought to differ in their cellular localization and specificity for particular lipid ligands. The protein encoded by;this gene localizes to late endosomes and lysosomes via a tyrosine-based motif in the cytoplasmic tail. This gene encodes a divergent member of the CD1 family of transmembrane glycoproteins, which are structurally related to the major histocompatibility complex (MHC) proteins and form heterodimers with beta-2-microglobulin. The CD1 proteins mediate the presentation of primarily lipid and glycolipid antigens of self or microbial origin to T cells. The human genome contains five CD1 family genes organized in a cluster on chromosome 1. The CD1 family members are thought to differ in their cellular localization and specificity for particular lipid ligands. The protein encoded by this gene localizes to late endosomes and lysosomes via a tyrosine-based motif in the cytoplasmic tail.
  • Synonyms

    CD1D; CD1d molecule; CD1d antigen , CD1D antigen, d polypeptide; antigen-presenting glycoprotein CD1d; R3G1; thymocyte antigen CD1D; CD1D antigen, d polypeptide; T-cell surface glycoprotein CD1d; differentiation antigen CD1-alpha-3; HMC class I antigen-like glycoprotein CD1D; R3; CD1A; MGC34622;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Homo sapiens (Human)
  • Human
  • Ovis aries (Sheep)
  • Rabbit
  • Rhesus Macaque
  • E.coli
  • E.coli expression system
  • E.Coli or Yeast
  • HEK293
  • Human Cell
  • Human Cells
  • In Vitro Cell Free System
  • Insect Cell
  • Mammalian Cell
  • Mammalian cells
  • Wheat Germ
  • C
  • His
  • Fc
  • His (Fc)
  • Avi
  • SUMO
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human CD1D & B2M-250H Recombinant Human CD1D & B2M protein, His-tagged HEK293 His Met1-Ser301 & Met1-Met119
Human CD1D-27107TH Recombinant Human CD1D Wheat Germ N/A 335 amino acids
Human CD1D-2188H Recombinant Human CD1D, His tagged Human Cell His
Human CD1D-828H Recombinant Human CD1D Protein, Fc-tagged HEK293 Fc
Human CD1D-10920H Recombinant Human CD1D, His-tagged E.coli His 18-302a.a.
Human CD1D & B2M-001HCL Recombinant Human CD1D & B2M cell lysate Human Cell N/A
Human CD1D-2479HCL Recombinant Human CD1D cell lysate Human Cell N/A
Human CD1D-166H Recombinant Human CD1D Protein, C-His-tagged E.coli C-His
Human CD1D-5279H Recombinant Human CD1D Protein (Met1-Ser301), C-His tagged Mammalian cells C-His Met1-Ser301
Human CD1D-231H Recombinant Human CD1D Protein, His-tagged Insect Cell His 20-301aa
Human CD1D-2659H Recombinant Human CD1D protein, His-SUMO-tagged E.coli His-SUMO 20-301aa
Human CD1D-151H Recombinant Human CD1D Protein, His-tagged Human Cells His
Human CD1D-64HF Recombinant Full Length Human CD1D Protein In Vitro Cell Free System 335 amino acids
Human CD1d-0916H Recombinant Human CD1d Protein (Glu20-Ser301), N-His tagged E.coli N-His Glu20-Ser301
Rabbit CD1D-3515S Recombinant Sylvilagus floridanus (Cottontail rabbit) CD1D, His-tagged E.Coli or Yeast His 275
Homo sapiens (Human) RFL31371HF Recombinant Full Length Human Antigen-Presenting Glycoprotein Cd1D(Cd1D) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (20-335)
Ovis aries (Sheep) RFL4802OF Recombinant Full Length Sheep Antigen-Presenting Glycoprotein Cd1D(Cd1D) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (18-335)
Rhesus Macaque CD1D-723R Recombinant Rhesus monkey CD1D Protein, His-tagged Mammalian Cell His
Rhesus Macaque CD1D-550R-B Recombinant Rhesus Macaque CD1D Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque CD1D-550R Recombinant Rhesus Macaque CD1D Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • CD1D Related Articles
  • CD1D Related Research Area

CD1D involved in several pathways and played different roles in them. We selected most pathways CD1D participated on our site, such as Hematopoietic cell lineage, Amoebiasis, which may be useful for your reference. Also, other proteins which involved in the same pathway with CD1D were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Hematopoietic cell lineageIL1R2;IL7R;ITGA1;FCER2;IL7;CD1D;IL3;GP9;ITGA2B
AmoebiasisCOL24A1;PTK2;IL-8;TNF;CD1D;LAMA3;GNA15;SERPINB3C;COL4A3

CD1D has several biochemical functions, for example, beta-2-microglobulin binding, cell adhesion molecule binding, endogenous lipid antigen binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CD1D itself. We selected most functions CD1D had, and list some proteins which have the same functions with CD1D. You can find most of the proteins on our site.

Function Related Protein
beta-2-microglobulin bindingHLA-E;HFE;CD1E;CD1d1;H2-Q10;CD1C;CD1D;FCGRT;CD1D2
cell adhesion molecule bindingFGFR1;PVR;VCAM1;ITGAL;GLYCAM1;PTPRD;NLGN1;SELL;CRTAM
endogenous lipid antigen bindingCD1E;CD1C;CD1B;CD1d1;CD1A;CD1D;CD1D2
exogenous lipid antigen bindingCD1C;CD1E;CD1A;CD1d1;CD1B;CD1D;CD1D2
histone bindingCTSL2;CHD2;TONSL;PHF21B;RCC1;NOC2L;MYSM1;H3F3A;PKN1
lipid antigen bindingCD1D;CD1d1
lipopeptide bindingCD1E;CD1D2;CD1B;CD1C;CD1d1;CD1A;TLR6;CD1D
receptor activityTNPO3;SEMA4D;CALCR;NLGN3;TACSTD2;MED14;NOTCH4;NPY2R;KLRB1F

CD1D has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CD1D here. Most of them are supplied by our site. Hope this information will be useful for your research of CD1D.

Rosales, C; Tang, DM; et al. CD1d serves as a surface receptor for oxidized cholesterol induction of peroxisome proliferator-activated receptor-gamma. ATHEROSCLEROSIS 239:224-231(2015).
Matsuda, T; Yanase, S; et al. The immunosenescence-related gene Zizimin2 is associated with early bone marrow B cell development and marginal zone B cell formation. IMMUNITY & AGEING 12:-(2015).
  • Q&As
  • Reviews

Q&As (5)

Ask a question
Are there any drugs targeting CD1D in development? 12/17/2022

Some pharmaceutical companies are researching and developing drugs that target CD1D for therapeutic purposes, although these are still in the early stages of development.

How is CD1D involved in lipid antigen presentation? 06/21/2022

CD1D binds and presents lipid antigens to NKT cells, facilitating immune responses against pathogens or aberrant cells.

How does CD1D differ from other antigen-presenting proteins like MHC? 02/20/2022

CD1D primarily presents lipid antigens, while major histocompatibility complex (MHC) proteins present peptide antigens. CD1D is crucial for lipid-specific immune responses.

In which diseases is CD1D deficiency implicated? 10/27/2020

CD1D deficiency has been associated with an increased susceptibility to certain infections and a potential link to autoimmune disorders.

Are there any clinical trials targeting CD1D? 02/04/2018

Yes, several clinical trials are exploring the modulation of CD1D in various diseases, including cancer and autoimmune disorders, to assess its therapeutic potential.

Customer Reviews (3)

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Reviews
03/14/2020

    The CD1D protein's versatility allows it to be effectively employed in various experimental designs, further enhancing its suitability for diverse research needs.

    02/27/2020

      Their extensive knowledge and expertise can help troubleshoot issues or provide guidance on experimental design, enabling you to overcome obstacles and achieve your research goals.

      04/15/2016

        In protein electron microscopy structure analysis, the CD1D protein demonstrates outstanding performance.

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