CD209
-
Official Full Name
CD209 molecule
-
Overview
This gene encodes a transmembrane receptor and is often referred to as DC-SIGN because of its expression on the surface of dendritic cells and macrophages. The encoded protein is involved in the innate immune system and recognizes numerous evolutionarily divergent pathogens ranging from parasites to viruses with a large impact on public health. The protein is organized into three distinct domains: an N-terminal transmembrane domain, a tandem-repeat neck domain and C-type lectin carbohydrate recognition domain. The extracellular region consisting of the C-type lectin and neck domains has a dual function as a pathogen recognition receptor and a cell adhesion receptor by binding carbohydrate ligands on the surface of microbes and endogenous cells. The neck region is important for homo-oligomerization which allows the receptor to bind multivalent ligands with high avidity. Variations in the number of 23 amino acid repeats in the neck domain of this protein are rare but have a significant impact on ligand binding ability. This gene is closely related in terms of both sequence and function to a neighboring gene (GeneID 10332; often referred to as L-SIGN). DC-SIGN and L-SIGN differ in their ligand-binding properties and distribution. Alternative splicing results in multiple variants.[provided by RefSeq, Feb 2009] -
Synonyms
CD209; CD209 molecule; CDSIGN; CLEC4L; DC-SIGN; DC-SIGN1; CD209 antigen; HIV gpl20-binding protein; C-type lectin domain family 4 member L; C-type lectin domain family 4, member L; dendritic cell-specific ICAM-3-grabbing non-integrin 1; dendritic cell-specific intracellular adhesion molecules (ICAM)-3 grabbing non-integrin;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Chlorocebus aethiops (Green monkey) (Cercopithecus aethiops)
- Human
- Rhesus
- Zebrafish
- CHO
- E.coli
- E.coli expression system
- HEK293
- Human Cell
- In Vitro Cell Free System
- Mammalian Cell
- Mammalian cells
- Wheat Germ
- C
- His
- Fc
- Flag
- GST
- hFc
- His (Fc)
- Avi
- Strep,Flag
- His|T7
- N/A
- N
Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
---|---|---|---|---|---|---|
Human | CD209-636H | Active Recombinant Human CD209 protein, Fc-tagged | Mammalian cells | Fc | Lys62-Ala404 | |
Human | CD209-635H | Active Recombinant Human CD209 protein | CHO | N/A | Gln59-Ala404 | |
Human | CD209-633H | Recombinant Human CD209 protein, hFc-tagged | HEK293 | hFc | Lys62-Ala404 | |
Human | CD209-634H | Recombinant Human CD209 protein, Fc-tagged | HEK293 | Fc | Lys62-Ala404 | |
Human | CD209-7173H | Recombinant Human CD209 protein, His & T7-tagged | E.coli | His/T7 | Glu70~Ala404 (Accession# Q9NNX6) | |
Human | CD209-0747H | Recombinant Human CD209 Protein | Wheat Germ | N/A | ||
Human | CD209-0748H | Recombinant Human CD209 Protein, GST-Tagged | Wheat Germ | GST | ||
Human | CD209-2986HCL | Recombinant Human CD209 cell lysate | Human Cell | N/A | ||
Human | CD209-643H | Recombinant Human CD209 protein, His-tagged | HEK293 | His | Gln 59 - Ala 404 | |
Human | CD209-3033HF | Recombinant Full Length Human CD209 Protein | In Vitro Cell Free System | 359 amino acids | ||
Human | CD209-14H | Recombinant Human CD209 Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi | ||
Human | CD209-0811H | Recombinant Human CD209 Protein (M1-A404), His/Strep, Flag tagged | E.coli | His/Strep,Flag | M1-A404 | |
Human | CD209-3034HF | Recombinant Full Length Human CD209 Protein, GST-tagged | In Vitro Cell Free System | GST | 404 amino acids | |
Human | CD209-0919H | Recombinant Human CD209 Protein (Glu70-Ala404), N-His tagged | E.coli | N-His | Glu70-Ala404 | |
Human | CD209-14H-B | Recombinant Human CD209 Protein Pre-coupled Magnetic Beads | HEK293 | |||
Human | CD209-4236H | Recombinant Human CD209 Protein (Gln59-Ala404), N-Fc tagged | Mammalian cells | N-Fc | Gln59-Ala404 | |
Human | CD209-057H | Recombinant Human CD209 Protein, C-His-tagged | E.coli | C-His | ||
Human | CD209-0810H | Recombinant Human CD209 Protein (M1-A404), Flag tagged | E.coli | Flag | M1-A404 | |
Chlorocebus aethiops (Green monkey) (Cercopithecus aethiops) | RFL7980CF | Recombinant Full Length Chlorocebus Aethiops Cd209 Antigen(Cd209) Protein, His-Tagged | E.coli expression system | His | Full Length (1-381) | |
Rhesus | CD209-728R | Recombinant Rhesus CD209 protein, Fc-tagged | HEK293 | Fc | Lys62-Glu381 | |
Rhesus | CD209-727R | Recombinant Rhesus CD209 protein, His-tagged | HEK293 | His | Lys62-Glu381 | |
Rhesus | CD209-726R | Recombinant Rhesus CD209 protein (Lys62-Glu381), His-tagged | HEK293 | His | ||
Zebrafish | CD209-7858Z | Recombinant Zebrafish CD209 | Mammalian Cell | His |
- Involved Pathway
- Protein Function
- Interacting Protein
- CD209 Related Articles
- CD209 Related Research Area
CD209 involved in several pathways and played different roles in them. We selected most pathways CD209 participated on our site, such as Phagosome, Tuberculosis, Measles, which may be useful for your reference. Also, other proteins which involved in the same pathway with CD209 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
---|---|
Phagosome | TUBB2B;CLEC7A;SEC22B;STX7;THBS1;ITGB3;HLA-DQA1;TUBA8L4;THBS4A |
Tuberculosis | AKT2;TRADD;H2-AB1;RAB7;Casp3;CORO1A;CD14;KSR1;IRAK1 |
Measles | IL13;PIK3R5;FCGR2B;PIK3CD;IRF3;TRP53;EIF3H;IRAK1;OAS1 |
CD209 has several biochemical functions, for example, carbohydrate binding, mannose binding, metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CD209 itself. We selected most functions CD209 had, and list some proteins which have the same functions with CD209. You can find most of the proteins on our site.
Function | Related Protein |
---|---|
carbohydrate binding | REG1B;CLEC2G;LY75;LGALS2;MAN2A1;CD93;FCN1;CLEC3B;CD209 |
mannose binding | CD209;CD209A;DPM1;MBL1;CD209C;CLN5;CLEC4M;MANBA;IGF2R |
metal ion binding | TRAFD1;ZNF35;ZNF32;SDHC;PHF2;PXDN;IMPDH1B;MUS81;ZHX2 |
peptide antigen binding | HLA-DRB5;HLA-A;H2-AB1;MHC1ZBA;MHC1ZDA;HLA-B;MHC1UHA;MHC1UEA;HLA-DRA |
protein binding | DAAM1;ASPSCR1;VPS41;PPP2R3C;DAPK3;RAP1GAP;SEMA4C;NR3C2;TNIK |
virion binding | HSP90B1;PPIA;PVRL1;APCS;CLEC4M;PTX3;HIPK2;CD209;TSG101 |
virus receptor activity | EFNB3;HSPA1A;SERPINB4;SIVA1;ITGB3;CD46;CD209;MRC1;SLC52A2 |
CD209 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CD209 here. Most of them are supplied by our site. Hope this information will be useful for your research of CD209.
VAC14; q03463-pro_0000278734
- Q&As
- Reviews
Q&As (5)
Ask a questionCD209 influences adaptive immune responses by modulating dendritic cell-T cell interactions. Understanding its role is critical for optimizing immunotherapy approaches, particularly in vaccine development.
CD209 recognizes glycosylated patterns on pathogens, particularly through interactions with high-mannose structures. This recognition is crucial for initiating innate immune responses.
Genetic polymorphisms in CD209 have been associated with susceptibility to infectious diseases, including tuberculosis and HIV, suggesting a role in modulating host-pathogen interactions.
CD209 facilitates immunological synapse formation by mediating adhesion between dendritic cells and T cells. Molecular events involve interactions with ICAM-3 and other adhesion molecules.
CD209 facilitates antigen capture by dendritic cells and modulates immune responses by mediating the interaction between dendritic cells and T cells during antigen presentation.
Customer Reviews (3)
Write a reviewThe team promptly addressed my inquiries and provided valuable assistance in selecting the right recombined protein for our research.
This product consistently delivers accurate results in our experiments.
Quick service! The team provided efficient assistance in choosing the right protein for us.
Ask a Question for All CD209 Products
Required fields are marked with *
My Review for All CD209 Products
Required fields are marked with *