CD59
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Official Full Name
CD59 molecule, complement regulatory protein
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Overview
This gene encodes a cell surface glycoprotein that regulates complement-mediated cell lysis, and it is involved in lymphocyte signal transduction. This protein is a potent inhibitor of the complement membrane attack complex, whereby it binds complement C8 and/or C9 during the assembly of this complex, thereby inhibiting the incorporation of multiple copies of C9 into the complex, which is necessary for osmolytic pore formation. This protein also plays a role in signal transduction pathways in the activation of T cells. Mutations in this gene cause CD59 deficiency, a disease resulting in hemolytic anemia and thrombosis, and which causes cerebral infarction. Multiple alternatively spliced transcript variants, which encode the same protein, have been identified for this gene. [provided by RefSeq, Jul 2008] -
Synonyms
CD59; CD59 molecule, complement regulatory protein; 1F5; EJ16; EJ30; EL32; G344; MIN1; MIN2; MIN3; MIRL; HRF20; MACIF; MEM43; MIC11; MSK21; 16.3A5; HRF-20; MAC-IP; p18-20; CD59 glycoprotein; protectin; 1F5 antigen; MEM43 antigen; Ly-6-like protein; T cell-activating protein; human leukocyte antigen MIC11; lymphocytic antigen CD59/MEM43; 20 kDa homologous restriction factor; membrane inhibitor of reactive lysis; membrane attack complex inhibition factor; membrane attack complex (MAC) inhibition factor; surface anitgen recognized by monoclonal antibody 16.3A5; CD59 antigen p18-20 (antigen identified by monoclonal antibodies 16.3A5, EJ16, EJ30, EL32 and G344);
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Cynomolgus Monkey
- Human
- Pig
- Rabbit
- Rat
- Rhesus Macaque
- Rhesus monkey
- E.coli
- HEK293
- HEK293F
- HEK293T
- Human Cell
- Human cells
- In Vitro Cell Free System
- Mammalian Cell
- Mammalian cells
- Wheat Germ
- Yeast
- C
- His
- DYKDDDDK
- Fc
- Fc|His
- Flag
- GST
- His (Fc)
- Avi
- His|S
- His|T7
- Myc
- DDK
- Myc|DDK
- N/A
- N
- hFc
- T7|His
- Involved Pathway
- Protein Function
- Interacting Protein
- CD59 Related Articles
- CD59 Related Research Area
CD59 involved in several pathways and played different roles in them. We selected most pathways CD59 participated on our site, such as Complement and coagulation cascades, Hematopoietic cell lineage, which may be useful for your reference. Also, other proteins which involved in the same pathway with CD59 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Complement and coagulation cascades | SERPINA1D;CFH;C3AR1;PROS1;PLAU;A2M;CR1L;SERPINA1;Serpina1c |
| Hematopoietic cell lineage | CD44;Cd24a;CD1D;IL9R;IL7R;CD36;DNTT;IL6;CD8B1 |
CD59 has several biochemical functions, for example, complement binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CD59 itself. We selected most functions CD59 had, and list some proteins which have the same functions with CD59. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| complement binding | C8G;CFB;CD59;CD46;CR2;C8A |
| protein binding | BLVRA;ARL14;GAS2L3;MAP4K4;SERPINB3C;TMEM106C;UBOX5;STXBP3A;LARP4B |
CD59 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CD59 here. Most of them are supplied by our site. Hope this information will be useful for your research of CD59.
TMED10; TMED2; C; EGFR; ganglioside_gm1; SMAD4; q7cgd4_yerpe; b3xyc5_sollc; ATP6AP2; CFTR
- Q&As
- Reviews
Q&As (6)
Ask a questionIn hemolytic diseases, the deficiency or dysfunction of CD59 may lead to excessive lysis of red blood cells because the formation of the complement C5b-9 complex cannot be effectively prevented.
Yes, the expression level of CD59 can vary in different cell types. In general, it is expressed higher in blood cells and some tumor cells.
When researching CD59, laboratories may encounter technical challenges such as selecting the appropriate assay, ensuring the quality and consistency of samples, and the complexity of interpreting results. In addition, CD59 expression variations in different cell types and experimental conditions need to be considered.
Aberrant expression of CD59 has been associated with a variety of diseases, including but not limited to hemolytic diseases, certain types of cancer, and autoimmune diseases.
CD59 expression can be detected using flow cytometry, immunofluorescence staining, or western blotting.
The current treatment for CD59 is still in the research stage, and there is no drug approved for clinical use. However, some studies are exploring the use of gene therapy or antibody therapy to modulate CD59 expression or function.
Customer Reviews (3)
Write a reviewThe quality is very high and the reliability is very helpful for our research results.
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