CD6
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Official Full Name
CD6 Molecule
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Overview
CD6 is a monomeric 105- or 130-kD membrane glycoprotein that is involved in T-cell activation. The size difference between the 2 CD6 forms is due to differences in phosphorylation -
Synonyms
T-cell differentiation antigen CD6; T12; CD6 antigen; OTTHUMP00000236965; OTTHUMP00000236967; OTTHUMP00000236969; OTTHUMP00000236970; OTTHUMP00000236971; TP120; FLJ44171; CD6; CD6 molecule;
- Recombinant Proteins
- Protein Pre-coupled Magnetic Beads
- Cell & Tissue Lysates
- Human
- Mouse
- Rat
- E.coli
- HEK293
- Human Cell
- In Vitro Cell Free System
- Insect cells
- Mammalian cells
- Wheat Germ
- C
- Fc
- hFc
- His
- GST
- hIgG
- His (Fc)
- Avi
- His|T7
- N/A
- N
- Involved Pathway
- Protein Function
- Interacting Protein
- CD6 Related Articles
- CD6 Related Research Area
CD6 involved in several pathways and played different roles in them. We selected most pathways CD6 participated on our site, such as Cell adhesion molecules (CAMs), which may be useful for your reference. Also, other proteins which involved in the same pathway with CD6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Cell adhesion molecules (CAMs) | HLA-DRB1;BLB2;ITGB2L;F11R.1;MAG;CLDNE;CLDN15LA;CLDN15LB;CNTNAP1 |
CD6 has several biochemical functions, for example, lipopolysaccharide binding, lipoteichoic acid binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CD6 itself. We selected most functions CD6 had, and list some proteins which have the same functions with CD6. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| lipopolysaccharide binding | P2RX7;BPIFC;TREM2;TRIL;BPIFA2;TLR4;PTAFR;PSMB4;CD14 |
| lipoteichoic acid binding | TLR2;LBP;CD6;TREM2;CD14 |
| protein binding | ECM1;YEATS4;WDR24;EIF4EBP3;HOXA10;KRT4;TBX22;FKBP3;AP1B1 |
| scavenger receptor activity | TMPRSS15;SCART1;SCARA3;HHIPL1;VTNB;LOXL2B;CFI;ACKR4;CD6 |
CD6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CD6 here. Most of them are supplied by our site. Hope this information will be useful for your research of CD6.
Sdcbp; LGALS1; LGALS3; ALCAM; SDCBP; GYG1; NFE2L1; acnA
- Q&As
- Reviews
Q&As (5)
Ask a questionCD6 provides co-stimulatory signals to T cells, influencing their activation and differentiation. This contributes to the regulation of adaptive immune responses.
CD6 genes exhibit polymorphisms, and certain variations are associated with susceptibility to autoimmune diseases, indicating a potential role in immune dysregulation.
CD6 is involved in immunological synapse formation, and its interactions with ligands, such as ALCAM, play a role in stabilizing T-cell interactions with antigen-presenting cells.
CD6 modulates T-cell trafficking and migration, impacting immune surveillance and inflammation. Its interactions with adhesion molecules contribute to these processes.
CD6 interacts with antigen-presenting cells, facilitating T-cell activation. This interaction is pivotal for the initiation and regulation of immune responses.
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