CDC42
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Official Full Name
cell division cycle 42
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Overview
The protein encoded by this gene is a small GTPase of the Rho-subfamily, which regulates signaling pathways that control diverse cellular functions including cell morphology, migration, endocytosis and cell cycle progression. This protein is highly similar to Saccharomyces cerevisiae Cdc 42, and is able to complement the yeast cdc42-1 mutant. The product of oncogene Dbl was reported to specifically catalyze the dissociation of GDP from this protein. This protein could regulate actin polymerization through its direct binding to Neural Wiskott-Aldrich syndrome protein (N-WASP), which subsequently activates Arp2/3 complex. Alternative splicing of this gene results in multiple transcript variants. Pseudogenes of this gene have been identified on chromosomes 3, 4, 5, 7, 8 and 20. [provided by RefSeq, Apr 2013] -
Synonyms
CDC42; cell division cycle 42; G25K; CDC42Hs; cell division control protein 42 homolog; G25K GTP-binding protein; GTP-binding protein, 25kD; growth-regulating protein; GTP binding protein, 25kDa; small GTP binding protein CDC42; dJ224A6.1.1 (cell division cycle 42 (GTP-binding protein, 25kD)); dJ224A6.1.2 (cell division cycle 42 (GTP-binding protein, 25kD));
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Assay Kits
- Chicken
- Cynomolgus Monkey
- Human
- Mouse
- Rat
- Rhesus Macaque
- Zebrafish
- E. coli
- E.coli
- HEK293
- HEK293T
- In Vitro Cell Free System
- Mammalian Cell
- Wheat Germ
- GST
- GST|His
- GST|pstS1
- His
- His (Fc)
- Avi
- Myc
- DDK
- MYC
- N/A
- N
- T7
- Involved Pathway
- Protein Function
- Interacting Protein
- CDC42 Related Articles
- CDC42 Related Research Area
- CDC42 Related Signal Pathway
CDC42 involved in several pathways and played different roles in them. We selected most pathways CDC42 participated on our site, such as MAPK signaling pathway, Ras signaling pathway, Rap signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with CDC42 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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MAPK signaling pathway | PPM1BB;ARRB2B;NFATC1;CASP3B;BRAF;IL1R2;PRKCBA;JIP1;NFKB2 |
Ras signaling pathway | GRIN1;PLA2G1B;BAD;PLCG2;RALBP1;NGFR;PAK3;GNG13;CALM3 |
Rap signaling pathway | VASP;ITGB2L;GNAS;CDC42;Itgam&Itgb2;FGF7;FYB;CDH1;NGF |
Chemokine signaling pathway | ROCK1;ROCK2;CXCL11;WAS;CXCL10;GSK3A;CCL15;SHC3;Cxcl15 |
Endocytosis | NTRK1;VPS29;RAB11FIP4B;ARFGAP3;CHMP4B;GRK7;SNX4;KITB;NEDD4L |
Axon guidance | NRP1A;CFL1;AKAP9;ITGB3A;Plxna2;KBTBD7;DLG3;HBEGF;SCN4A |
VEGF signaling pathway | PIK3CA;RAC3B;PRKCG;PRKCA;PPP3CC;PTK2;CDC42L;PPP3CCA;PTGS2 |
Focal adhesion | SHC3;COL27A1A;PAK2B;COL6A1;CHAD;ITGA1;ARHGAP5;TNC;PDGFAA |
Adherens junction | SMAD3;ACTB;NLK;ACTN4;TCF7L1A;WASL;CSNK2A2A;IGF1R;RAC2 |
Tight junction | CRB3;PRKCE;HCLS1;LLGL2;SHROOM1;CLDNF;SHROOM2;PRKCG;CLDN18 |
T cell receptor signaling pathway | BCL10;MAPK1;PAK1;NFKBIA;MAP3K7;TEC;IKBKB;Il2;IL5 |
Fc gamma R-mediated phagocytosis | VAV3;CFL2;PLD2;ARPC1A;WASF2;RPS6KB1;PRKCB;CFL1;PIP5K1C |
Leukocyte transendothelial migration | CLDN9;CLDN22;MYLPF;PIK3CB;PTK2B;VAV1;PLCG2;MMP9;PRKCA |
Neurotrophin signaling pathway | BCL2;IRAK1;SHC2;CALML5;MAGED1;RPS6KA1;NGFR;CAMK4;MAP2K1 |
Regulation of actin cytoskeleton | RAF1B;PPP1CBL;RDX;ITGAL;ENAH;ITGB3B;MLCK2;ARHGEF12;RAC2 |
GnRH signaling pathway | CAMK2D;CACNA1SA;RAF1;CALM2A;GNRH3;MAPK9;PRKCBB;RAF1A;GNRHR1 |
Non-alcoholic fatty liver disease (NAFLD) | TRAF2;PIK3CD;UQCR11;NDUFA2;Fasl;PIK3R5;COX4I2;BID;NDUFA3 |
Bacterial invasion of epithelial cells | SHC1;WASF2;WASF1;CAV1;CLTA;FN1;SEPT1;SHC2;CTNNA1 |
Epithelial cell signaling in Helicobacter pylori infection | ATP6V1C2;ATP6V0E1;IKBKB;RAC1;IL-8;PLCG2;ATP6V1D;PLCG1;ATP6V1H |
Pathogenic Escherichia coli infection | RHOA;TLR5;ROCK2;ACTB;WAS;ROCK1;CTTN;ARPC5L;TUBB7P |
Shigellosis | SRC;WASF1;UBE2D2;RELA;PFN2;CTTN;MAPK12;MAD2L2;RAC1 |
Salmonella infection | FLNB;WASLA;MAPK9;PFN3;CDC42L2;CXCL8B.3;RELA;ROCK1;KLC1A |
Pathways in cancer | FZD9;PTEN;RALB;TGFB3;SMAD2;CUL2;FN1;Pdgfa&Pdgfb;GNG3 |
Viral carcinogenesis | STAT5A;RBPJ;CCND1;SRC;YWHAB;HIST1H4G;HIST1H2BA;HDAC7A;EP300 |
Proteoglycans in cancer | ARHGEF12;WNT7B;ITGA5;WNT9B;FLNC;FLNA;DROSHA;IGF1;RHOA |
Renal cell carcinoma | KRAS;PAK3;PIK3R2;TGFB2;ARNT;RAP1A;AHA-1;TGFA;MAP2K1 |
Pancreatic cancer | RALBP1;RAD51;ARHGEF6;STAT1;STAT3;RAC3;AKT2;MAPK10;MAPK1 |
CDC42 has several biochemical functions, for example, GTP binding, GTP-dependent protein binding, GTPase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CDC42 itself. We selected most functions CDC42 had, and list some proteins which have the same functions with CDC42. You can find most of the proteins on our site.
Function | Related Protein |
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GTP binding | MFN1;TUBA8L3;RAB1B;RAB19;RAB5C;DIRAS2;EHD1;NPR2;GUF1 |
GTP-dependent protein binding | RAB38;AP3B1;GCH1;RAB32;ARFIP2;CDC42;PPIAL4A;RAPGEF6;RASGRP4 |
GTPase activity | RAB1;DNM2A;HBS1L;RAB3C;RABL2;RAB2B;RAB42;RHOB;GNAO1 |
apolipoprotein A-I receptor binding | CDC42;APOA1;NR1H2 |
identical protein binding | FXR2;GUCY2E;SIRT1;IGF2R;JMJD6;PRC1;CTSC;MUL1;NDE1 |
mitogen-activated protein kinase kinase kinase binding | TRAF6;PPEF2;STK38;DUSP19;CDC42;MAPK8IP3;CDC37;MAPK1;TRAF2 |
protein binding | SLC2A1;DAP3;RET;YBX1;CUL4A;CNTNAP2;HIRA;ZBTB43;RWDD2B |
protein kinase binding | PFKFB2;AP1B1;TRPV4;LAX1;GOLGA2;PPP1CC;JAK2;PTPN1;SMAD1 |
thioesterase binding | RAC1;HAUS7;CDC42;TRAF3;CALM;TRAF2;CALM1;TRAF5;TRAF6 |
ubiquitin protein ligase activity | RLIM;MSL2;RNF121;RNF220;RNF146;RNF144A;RNF25;ARIH1;MED17 |
CDC42 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CDC42 here. Most of them are supplied by our site. Hope this information will be useful for your research of CDC42.
PAK1; WAS
- Q&As
- Reviews
Q&As (7)
Ask a questionCDC42 controls cytoskeletal dynamics, leading to changes in cell shape and movement.
CDC42 is important in neuronal development and plays a role in forming and remodeling synaptic connections.
Changes in CDC42 activity can impact aging processes and contribute to the development of age-related diseases.
CDC42 facilitates cancer progression by enhancing cell migration, invasion, and metastatic potential.
CDC42 aids in wound healing and regeneration by guiding cell migration and tissue restructuring.
CDC42 is crucial for cell division and cycle progression, coordinating cellular events for proper division.
CDC42 regulates immune cell movement and activation, essential for immune response and surveillance.
Customer Reviews (3)
Write a reviewReliable protein crystallography, essential for structural studies.
Exceptional protein engineering services, meets our lab's needs.
Efficient peptide synthesis, crucial for our peptide research.
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