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CDH18

Official Full Name

cadherin 18, type 2
Overview

This gene encodes a type II classical cadherin from the cadherin superfamily of integral membrane proteins that mediate calcium-dependent cell-cell adhesion. Mature cadherin proteins are composed of a large N-terminal extracellular domain, a single membrane-spanning domain, and a small, highly conserved C-terminal cytoplasmic domain. Type II (atypical) cadherins are defined based on their lack of a HAV cell adhesion recognition sequence specific to type I cadherins. This particular cadherin is expressed specifically in the central nervous system and is putatively involved in synaptic adhesion, axon outgrowth and guidance.
Synonyms

CDH18; cadherin 18, type 2; cadherin-18; CDH14; EY CADHERIN; cadherin-14; ey-cadherin; cadherin-like 24; CDH24; CDH14L;

Type

Recombinant Proteins
Cell & Tissue Lysates

Species

Cynomolgus Monkey
Human
Rhesus

Source

E.coli
HEK293
Human Cell
In Vitro Cell Free System
Wheat Germ

Tag

GST
His
N/A
N
T7|His

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	CDH18-11034H	Recombinant Human CDH18, GST-tagged	E.coli	GST	25-382a.a.	$319 / 25ug
Human	CDH18-0979H	Recombinant Human CDH18 Protein, GST-Tagged	Wheat Germ	GST		Inquiry
Human	CDH18-47H	Recombinant Human CDH18 protein, T7/His-tagged	E.coli	T7/His		Inquiry
Human	CDH18-3139HF	Recombinant Full Length Human CDH18 Protein, GST-tagged	In Vitro Cell Free System	GST	790 amino acids	Inquiry
Human	CDH18-718H	Recombinant Human CDH18 Protein, His-tagged	E.coli	N-His	Gly54-Phe268	Inquiry
Cynomolgus Monkey	CDH18-85C	Recombinant Cynomolgus CDH18, His tagged	Human Cell	His		Inquiry
Cynomolgus Monkey	CDH18-765CCL	Recombinant Cynomolgus CDH18 cell lysate	Human Cell	N/A		Inquiry
Rhesus	CDH18-097R	Recombinant Rhesus CDH18 protein, His-tagged	HEK293	His	Met1-Ser608	Inquiry

Involved Pathway
Protein Function
Interacting Protein
CDH18 Related Articles

CDH18 involved in several pathways and played different roles in them. We selected most pathways CDH18 participated on our site, such as Adherens junctions interactions, Cell junction organization, Cell-Cell communication, which may be useful for your reference. Also, other proteins which involved in the same pathway with CDH18 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Adherens junctions interactions	CDH10;PVRL1A;CDH12;PTBP3;CDH7;CDH8;CADM2B;CDH3;CDH18
Cell junction organization	JUPA;CDH10A;INADL;CLDN20;CLDN23;PLEC;CLDN7;CD151;CLDN3
Cell-Cell communication	DCC;KIRREL;PVRL2L;SIRPB1;FBLIM1;COL17A1A;CADM2A;CDH13;PARVB
Cell-cell junction organization	CDH3;CDH18A;CADM2B;CDH8;PVRL2L;CADM2A;CADM2;CDH9;CTNND1

CDH18 has several biochemical functions, for example, calcium ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CDH18 itself. We selected most functions CDH18 had, and list some proteins which have the same functions with CDH18. You can find most of the proteins on our site.

Function	Related Protein
calcium ion binding	PVALB4;SCIN;ANKRD5;ITPR3;NELL2;DGKG;THBS3A;CPNE1;DSG1A

CDH18 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CDH18 here. Most of them are supplied by our site. Hope this information will be useful for your research of CDH18.

MYOG

Mackowiak, II; Gentile, LB; et al. E-cadherin in canine mast cell tumors: Decreased expression and altered subcellular localization in Grade 3 tumors. VETERINARY JOURNAL 194:405-411(2012).

Yoshimura, K; Meckel, KF; et al. Integrin alpha 2 Mediates Selective Metastasis to the Liver. CANCER RESEARCH 69:7320-7328(2009).