CDK7

Official Full Name

cyclin-dependent kinase 7

Background

The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe cdc2, and are known to be important regulators of cell cycle progression. This protein forms a trimeric complex with cyclin H and MAT1, which functions as a Cdk-activating kinase (CAK). It is an essential component of the transcription factor TFIIH, that is involved in transcription initiation and DNA repair. This protein is thought to serve as a direct link between the regulation of transcription and the cell cycle.

Synonyms

CDK7; cyclin-dependent kinase 7; cyclin dependent kinase 7 (homolog of Xenopus MO15 cdk activating kinase) , cyclin dependent kinase 7 (MO15 homolog, Xenopus laevis, cdk activating kinase); CAK; CAK1; CDKN7; MO15; STK1; 39 KDa protein kinase; CAK 1; CDK 7; Cdk activating kinase; CDK-activating kinase; CDK7_HUMAN; CDKN 7; Cell division protein kinase 7; Crk 4; Crk4; Cyclin dependent kinase 7; Homolog of Xenopus MO15 cdk activating kinase; Kinase subunit of CAK; MO15 homolog Xenopus laevis cdk activating kinase; p39 MO15; p39MO15; Serine threonine kinase Stk 1; Serine threonine kinase Stk1; Serine threonine protein kinase 1; Serine threonine protein kinase MO15; Serine/threonine kinase Stk 1; Serine/threonine kinase Stk1; Serine/threonine protein kinase 1; Serine/threonine protein kinase MO15; STK 1; TFIIH basal transcription factor complex kinase subunit; protein kinase; OTTHUMP00000125195; OTTHUMP00000222032; OTTHUMP00000222033; CDK-activating kinase 1; serine/threonine-protein kinase 1; homolog of Xenopus MO15 Cdk-activating kinase; cyclin-dependent kinase 7 (MO15 homolog, Xenopus laevis, cdk-activating kinase); HCAK