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CDKN1A

  • Official Full Name

    cyclin-dependent kinase inhibitor 1A (p21, Cip1)

  • Overview

    This gene encodes a potent cyclin-dependent kinase inhibitor. The encoded protein binds to and inhibits the activity of cyclin-CDK2 or -CDK4 complexes, and thus functions as a regulator of cell cycle progression at G1. The expression of this gene is tightly controlled by the tumor suppressor protein p53, through which this protein mediates the p53-dependent cell cycle G1 phase arrest in response to a variety of stress stimuli. This protein can interact with proliferating cell nuclear antigen (PCNA), a DNA polymerase accessory factor, and plays a regulatory role in S phase DNA replication and DNA damage repair. This protein was reported to be specifically cleaved by CASP3-like caspases, which thus leads to a dramatic activation of CDK2, and may be instrumental in the execution of apoptosis following caspase activation. Multiple alternatively spliced variants have been found for this gene. [provided by RefSeq, Nov 2010]
  • Synonyms

    CDKN1A; cyclin-dependent kinase inhibitor 1A (p21, Cip1); P21; CIP1; SDI1; WAF1; CAP20; CDKN1; MDA-6; p21CIP1; cyclin-dependent kinase inhibitor 1; DNA synthesis inhibitor; CDK-interacting protein 1; CDK-interaction protein 1; wild-type p53-activated fragment 1; melanoma differentiation associated protein 6;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Antibody
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Rat
  • Rhesus Macaque
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Mammalian Cell
  • Mammalian cells
  • Mouse
  • Wheat Germ
  • C
  • Myc
  • DDK
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • His|MBP
  • His|T7
  • MYC
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human CDKN1A-7158H Recombinant Human CDKN1A, His-tagged E.coli His False
Human CDKN1A-4837H Recombinant Human Cyclin-Dependent Kinase Inhibitor 1A, GST-tagged E.coli GST
Human CDKN1A-311H Recombinant Human CDKN1A protein, His/MBP-tagged E.coli His/MBP 1-73 aa
Human CDKN1A-312H Recombinant Human CDKN1A protein, His/MBP-tagged E.coli His/MBP 79-164 aa
Human CDKN1A-169H Recombinant Human Cyclin-dependent Kinase Inhibitor 1A (p21, Cip1) E.coli N/A
Human CDKN1A-1053H Recombinant Human CDKN1A Protein, GST-Tagged Wheat Germ GST
Human CDKN1A-7157H Recombinant Human Cyclin-Dependent Kinase Inhibitor 1A (p21, Cip1), His-tagged E.coli His 1-164aa
Human CDKN1A-30053TH Recombinant Human CDKN1A E.coli N/A
Human CDKN1A-116H Recombinant Human CDKN1A Protein, His-tagged E.coli His Ser2-Pro164
Human CDKN1A-7618HCL Recombinant Human CDKN1A 293 Cell Lysate HEK293 N/A
Human CDKN1A-045H Recombinant Human CDKN1A Protein, MYC/DDK-tagged, C13 and N15-labeled HEK293 C-Myc/DDK
Human CAB-2544MH Mouse Anti-Human p21/WAF1 Monoclonal Antibody Mouse N/A
Human CDKN1A-3186H Recombinant Human CDKN1A protein, His-tagged E.coli His 72-164 aa
Human CDKN1A-2680H Recombinant Human CDKN1A protein, GST-tagged E.coli GST 2-164aa
Human CDKN1A-567H Recombinant Human CDKN1A Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human CDKN1A-3175HF Recombinant Full Length Human CDKN1A Protein, GST-tagged In Vitro Cell Free System GST 164 amino acids
Human CDKN1A-567H-B Recombinant Human CDKN1A Protein Pre-coupled Magnetic Beads HEK293
Human CDKN1A-381HFL Recombinant Full Length Human CDKN1A Protein, C-Flag-tagged Mammalian cells Flag
Human CDKN1A-1075H Recombinant Human CDKN1A Protein (Met1-Pro164), His tagged E.coli His Met1-Pro164
Mouse CDKN1A-3220M Recombinant Mouse CDKN1A Protein Mammalian Cell His
Mouse Cdkn1a-869M Recombinant Mouse Cdkn1a Protein, MYC/DDK-tagged HEK293T MYC/DDK
Mouse Cdkn1a-1774M Recombinant Mouse Cdkn1a protein, His-tagged E.coli His Ser2~Pro159
Mouse CDKN1A-1534M Recombinant Mouse CDKN1A Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse CDKN1A-1534M-B Recombinant Mouse CDKN1A Protein Pre-coupled Magnetic Beads HEK293
Rat Cdkn1a-1251R Recombinant Rat Cdkn1a protein, His & T7-tagged E.coli His/T7 Met1~Pro164 (Accession # Q64315)
Rhesus Macaque CDKN1A-793R Recombinant Rhesus monkey CDKN1A Protein, His-tagged Mammalian Cell His
Rhesus Macaque CDKN1A-619R-B Recombinant Rhesus Macaque CDKN1A Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque CDKN1A-619R Recombinant Rhesus Macaque CDKN1A Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Zebrafish CDKN1A-6910Z Recombinant Zebrafish CDKN1A Mammalian Cell His
Chicken CDKN1A-5966C Recombinant Chicken CDKN1A Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • CDKN1A Related Articles
  • CDKN1A Related Research Area
  • CDKN1A Related Signal Pathway

CDKN1A involved in several pathways and played different roles in them. We selected most pathways CDKN1A participated on our site, such as AKT phosphorylates targets in the cytosol, AMPK signaling, Adaptive Immune System, which may be useful for your reference. Also, other proteins which involved in the same pathway with CDKN1A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
AKT phosphorylates targets in the cytosolAKT3;CDKN1B;CDKN1A;CHUK
AMPK signalingSLC2A4RG;CDKN1A;CAMKK2;ADRA1B;PPARGC1B;INS-IGF2;CPT1C;ELAVL1;CPT1A
Adaptive Immune SystemDYNLL2;STIM1B;FBXO44;ASB17;RBCK1;RNF6;NRG3;KIF11;RACGAP1
AdipogenesisGTF3AA;NRIP1;MEF2B;EBF1;NAMPT;CISD1;EGR2B;MIXL1;PLIN2
AhR pathwayAHR;FLG;JUND;CDKN1B;CYP1A2;CDKN1A;CYP1A1;NQO1;PTGES3
Alpha6-Beta4 Integrin Signaling PathwayCD151L;CD151;EGFR;MST1R;SMAD3B;CLCA1;DST;RTKN;CDKN1A
Androgen receptor signaling pathwayKDM1A;GNB2L1;DSTN;RHOB;SMARCE1;RAD9A;RAD54L2;RNF14;JUN
Angiopoietin receptor Tie2-mediated signalingCRK;CDKN1A;GRB14;BMX;ELF2;DOK2;GRB7;AGTR1;ELF1

CDKN1A has several biochemical functions, for example, cyclin binding, cyclin-dependent protein kinase activating kinase activity, cyclin-dependent protein serine/threonine kinase inhibitor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CDKN1A itself. We selected most functions CDKN1A had, and list some proteins which have the same functions with CDKN1A. You can find most of the proteins on our site.

Function Related Protein
cyclin bindingPTCH1;INCA1;CDK4;MDFIC;CDKN1A;HDAC3;CDK6;CUL3;CDK5RAP3
cyclin-dependent protein kinase activating kinase activityCDKN1A;ALPK2
cyclin-dependent protein serine/threonine kinase inhibitor activityCDKN1A;CDKN2D;HEXIM1;CDKN2C;CDKN1B;KAT2B;CDKN1BB;CDKN1BA;Casp3
metal ion bindingATP1A1A.2;ATP2B3B;ZSCAN20;CYP8B2;NUAK1;MOB2;ADI1;ZNF193;PPARAB
protein bindingOSBPL3;TCEB2;FUS;LINGO1B;PRPS1;MVP;ANKS4B;PKP2;ZNF114
protein complex bindingLCA5;Cel;TG;SLC27A5;NDUFA8;CDK5RAP2;MTHFR;BCAP31;FLCN
ubiquitin protein ligase bindingTMBIM6;UBE2S;CD40;WFS1;CDC34A;ANKRD32;ATXN3;PA2G4;WASH

CDKN1A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CDKN1A here. Most of them are supplied by our site. Hope this information will be useful for your research of CDKN1A.

CDK2; PCNA

Chen, TC; Lin, KT; et al. Using an in Situ Proximity Ligation Assay to Systematically Profile Endogenous Protein-Protein Interactions in a Pathway Network. JOURNAL OF PROTEOME RESEARCH 13:5339-5346(2014).
Atsaves, V; Lekakis, L; et al. The oncogenic JUNB/CD30 axis contributes to cell cycle deregulation in ALK plus anaplastic large cell lymphoma. BRITISH JOURNAL OF HAEMATOLOGY 167:514-523(2014).
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