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CDKN2C

  • Official Full Name

    cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)

  • Overview

    The protein encoded by this gene is a member of the INK4 family of cyclin-dependent kinase inhibitors. This protein has been shown to interact with CDK4 or CDK6, and prevent the activation of the CDK kinases, thus function as a cell growth regulator that controls cell cycle G1 progression. Ectopic expression of this gene was shown to suppress the growth of human cells in a manner that appears to correlate with the presence of a wild-type RB1 function. Studies in the knockout mice suggested the roles of this gene in regulating spermatogenesis, as well as in suppressing tumorigenesis. Two alternatively spliced transcript variants of this gene, which encode an identical protein, have been reported. [provided by RefSeq, Jul 2008]
  • Synonyms

    CDKN2C; cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4); p18; INK4C; p18-INK4C; cyclin-dependent kinase 4 inhibitor C; p18-INK6; CDK6 inhibitor p18; cyclin-dependent inhibitor; cyclin-dependent kinase 6 inhibitor p18;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rhesus Macaque
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • Strep
  • Myc
  • DDK
  • MYC
  • N/A
  • No tag
  • T7
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human Cdkn2c-6983H Recombinant Human p18INK4C, GST-tagged E.coli GST Full length
Human CDKN2C-30048TH Recombinant Human CDKN2C, His-tagged E.coli His 168 amino acids
Human CDKN2C-1377H Recombinant Human Cyclin-Dependent Kinase Inhibitor 2C (p18, inhibits CDK4), His-tagged E.coli His
Human CDKN2C-30052TH Recombinant Human CDKN2C E.coli N/A
Human CDKN2C-30049TH Recombinant Human CDKN2C, T7 -tagged E.coli T7
Human CDKN2C-1475H Recombinant Human CDKN2C, GST-tagged E.coli GST
Human CDKN2C-3049H Recombinant Human CDKN2C, T7-tagged E.coli T7
Human CDKN2C-117H Recombinant Human CDKN2C protein, T7-tagged E.coli T7
Human CDKN2C-1065H Recombinant Human CDKN2C Protein, GST-Tagged Wheat Germ GST
Human CDKN2C-7612HCL Recombinant Human CDKN2C 293 Cell Lysate HEK293 N/A
Human CDKN2C-4708H Recombinant Human CDKN2C Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human CDKN2C-2988H Recombinant Human CDKN2C protein, His-tagged E.coli His 1-75 aa
Human CDKN2C-1294H Recombinant Human CDKN2C Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human CDKN2C-0571H Recombinant Human CDKN2C Protein (M1-Q168), His/Strep tagged E.coli His/Strep M1-Q168
Human CDKN2C-0570H Recombinant Human CDKN2C Protein (M1-Q168), Tag Free E.coli No tag M1-Q168
Human CDKN2C-3230HF Recombinant Full Length Human CDKN2C Protein, GST-tagged In Vitro Cell Free System GST 168 amino acids
Mouse Cdkn2c-871M Recombinant Mouse Cdkn2c Protein, MYC/DDK-tagged HEK293T MYC/DDK
Rhesus Macaque CDKN2C-796R Recombinant Rhesus monkey CDKN2C Protein, His-tagged Mammalian Cell His
Rhesus Macaque CDKN2C-622R-B Recombinant Rhesus Macaque CDKN2C Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque CDKN2C-622R Recombinant Rhesus Macaque CDKN2C Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Zebrafish CDKN2C-7899Z Recombinant Zebrafish CDKN2C Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • CDKN2C Related Research Area

CDKN2C involved in several pathways and played different roles in them. We selected most pathways CDKN2C participated on our site, such as Cell Cycle, Cell Cycle, Mitotic, Cellular Senescence, which may be useful for your reference. Also, other proteins which involved in the same pathway with CDKN2C were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Cell CycleCDC20;SMAD3;YWHAQB;MDM2;CENPE;BABAM1;SMC1B;RCC2;NEK7
Cell Cycle, MitoticCDKN2B;FGFR1OP;ACTR1A;TUBB4A;NCAPH2;NDEL1B;DYNC1I2;DHFR;CDT1
Cellular SenescenceH3F3D;HIST1H1C;MINK1;KAT5;RBB4L;IGFBP7;POT1A;HTATIP;TERF2
Cellular responses to stressATG7;DNAJB6;UVRAG;CBX6A;CBX8B;BMI1A;ATG4A;HIST1H1D;AGO3
Cyclin D associated events in G1CDKN2D;CKS1B;CDK7;E2F4;CDKN2B;PIANP;CDKN2C
E2F transcription factor networkRBBP8;YY1;DHFR;E2F4;TRIM28;CES5A;CBX5;SMARCA2;MYBL2
G1 PhaseCDKN2C;CDKN2B;CKS1B;E2F4;CDKN2D;PIANP

CDKN2C has several biochemical functions, for example, cyclin-dependent protein serine/threonine kinase inhibitor activity, protein binding, protein kinase binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CDKN2C itself. We selected most functions CDKN2C had, and list some proteins which have the same functions with CDKN2C. You can find most of the proteins on our site.

Function Related Protein
cyclin-dependent protein serine/threonine kinase inhibitor activityCDKN2A;CDKN2C;CDKN1A;CDKN1B;CDKN1BA;Casp3;INCA1;CDKN2B;CDKN1BB
protein bindingCACNA1SB;CDC42EP5;DDX21;CDK13;SRSF1;MT2A;FAM92A;NKX3-1;TCF25
protein kinase bindingITGB1BP1;TRIB3;PTK2;TRIM22;ZC3HC1;FBXO7;RAD9;CCND3;SPDYA

CDKN2C has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CDKN2C here. Most of them are supplied by our site. Hope this information will be useful for your research of CDKN2C.

CDK4; CDK6; AHCYL1

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