The protein encoded by this intronless gene is a bZIP transcription factor which can bind as a homodimer to certain DNA regulatory regions. It can also form heterodimers with the related protein CEBP-alpha. The encoded protein is important in the regulation of genes involved in immune and inflammatory responses, and may be involved in the regulation of genes associated with activation and/or differentiation of macrophages. The cytogenetic location of this locus has been reported as both 8p11 and 8q11.
CEBPD; CCAAT/enhancer binding protein (C/EBP), delta; CCAAT/enhancer-binding protein delta; C/EBP delta; CELF; CRP3; NF IL6 beta; C/EBP related protein 3; CCAAT/enhancer binding protein delta; CEBP D; CEBPD_HUMAN; Crp 3; NF-IL6-beta; Nuclear factor NF IL6 beta; Nuclear factor NF-IL6-beta; OTTHUMP00000221850; C/EBP-delta
Zhang, J; Chang, L; et al. Rad GTPase inhibits cardiac fibrosis through connective tissue growth factor. CARDIOVASCULAR RESEARCH 91:90-98(2011).
Lee, J; Lee, J; et al. Ultraviolet A Regulates Adipogenic Differentiation of Human Adipose Tissue-derived Mesenchymal Stem Cells via Up-regulation of Kruppel-like Factor 2. JOURNAL OF BIOLOGICAL CHEMISTRY 285:32647-32656(2010).