CELA3B
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Official Full Name
chymotrypsin-like elastase family, member 3B
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Overview
Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Humans have six elastase genes which encode the structurally similar proteins elastase 1, 2, 2A, 2B, 3A, and 3B. Unlike other elastases, elastase 3B has little elastolytic activity. Like most of the human elastases, elastase 3B is secreted from the pancreas as a zymogen and, like other serine proteases such as trypsin, chymotrypsin and kallikrein, it has a digestive function in the intestine. Elastase 3B preferentially cleaves proteins after alanine residues. Elastase 3B may also function in the intestinal transport and metabolism of cholesterol. Both elastase 3A and elastase 3B have been referred to as protease E and as elastase 1, and excretion of this protein in fecal material is frequently used as a measure of pancreatic function in clinical assays. -
Synonyms
CELA3B; chymotrypsin-like elastase family, member 3B; E1; CBPP; EL-1; ELA3B; chymotrypsin-like elastase family member 3B; elastase 1; protease E; elastase-3B; proteinase E; elastase IIIB; fecal elastase 1; OTTHUMP00000002837; pancreatic elastase 1; elastase 3B, pancreatic; pancreatic endopeptidase E; cholesterol-binding pancreatic protease;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Native Proteins
- Human
- Mouse
- Pig
- Rat
- Rhesus Macaque
- E.coli
- HEK293
- In Vitro Cell Free System
- Insect cell
- Mammalian Cell
- Porcine Pancreas
- Wheat Germ
- Yeast
- GST
- His
- His (Fc)
- Avi
- Myc
- His|Myc
- N/A
- N
- Involved Pathway
- Protein Function
- Interacting Protein
CELA3B involved in several pathways and played different roles in them. We selected most pathways CELA3B participated on our site, such as Pancreatic secretion, Protein digestion and absorption, which may be useful for your reference. Also, other proteins which involved in the same pathway with CELA3B were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Pancreatic secretion | SLC26A3;RAB8A;RAP1A;CLCA3;CLCA5;CELA2B;CLCA1;PLA2G2A;PNLIPRP2 |
| Protein digestion and absorption | ATP1A3;CTRL;CPA1;SLC16A10;ATP1B4;SLC8A1;SLC9A3;KCNN4;PRSS2 |
CELA3B has several biochemical functions, for example, peptidase activity, serine-type endopeptidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CELA3B itself. We selected most functions CELA3B had, and list some proteins which have the same functions with CELA3B. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| peptidase activity | ADAM1B;CAPN5A;FAM105B;GM12824;HM13;HTRA1B;NAPSA;CLPP;ST14A |
| serine-type endopeptidase activity | GZMH;TMPRSS11D;TPP2;TPSAB1;Gzmg;KLK13;Gzmd;CFI;KLK1B24 |
CELA3B has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CELA3B here. Most of them are supplied by our site. Hope this information will be useful for your research of CELA3B.
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