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CERS2

  • Official Full Name

    ceramide synthase 2

  • Overview

    This gene encodes a protein that has sequence similarity to yeast longevity assurance gene 1. Mutation or overexpression of the related gene in yeast has been shown to alter yeast lifespan. The human protein may play a role in the regulation of cell growth. Alternatively spliced transcript variants encoding the same protein have been described.
  • Synonyms

    LAG1 homolog, ceramide synthase 2; LAG1 longevity assurance homolog 2 (S. cerevisiae); SP260; MGC987; CerS2; OTTHUMP00000033029; FLJ10243; OTTHUMP00000033030; L3; OTTHUMP00000033031; longevity assurance (LAG1, S. cerevisiae) homolog 2; ceramide synthase 2; Tumor metastasis-suppressor gene 1 protein; LAG1 longevity assurance 2; TMSG1; LAG1 longevity assurance homolog 2; LASS2; OTTHUMP00000033028; CERS2 ceramide synthase 2;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Bos taurus (Bovine)
  • Homo sapiens (Human)
  • Human
  • Mouse
  • Mus musculus (Mouse)
  • E.coli expression system
  • HEK293
  • HEK293T
  • Mammalian Cell
  • Mammalian cells
  • Flag
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human CERS2-820H Recombinant Human CERS2 Mammalian Cell His
Human CERS2-4819HCL Recombinant Human LASS2 293 Cell Lysate HEK293 N/A
Human CERS2-1295HFL Recombinant Full Length Human CERS2 Protein, C-Flag-tagged Mammalian cells Flag
Human CERS2-578H Recombinant Human CERS2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human CERS2-578H-B Recombinant Human CERS2 Protein Pre-coupled Magnetic Beads HEK293
Human CERS2-1277H Recombinant Human CERS2 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Mouse Cers2-2121M Recombinant Mouse Cers2 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Bos taurus (Bovine) RFL13608BF Recombinant Full Length Bovine Ceramide Synthase 2(Cers2) Protein, His-Tagged E.coli expression system His Full Length (1-380)
Homo sapiens (Human) RFL586HF Recombinant Full Length Human Ceramide Synthase 2(Cers2) Protein, His-Tagged E.coli expression system His Full Length (1-380)
Mus musculus (Mouse) RFL23784MF Recombinant Full Length Mouse Ceramide Synthase 2(Cers2) Protein, His-Tagged E.coli expression system His Full Length (1-380)
  • Involved Pathway
  • Protein Function
  • Interacting Protein

CERS2 involved in several pathways and played different roles in them. We selected most pathways CERS2 participated on our site, such as Sphingolipid metabolism, Metabolic pathways, Sphingolipid signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with CERS2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Sphingolipid metabolismDEGS1;GAL3ST1A;ARSJ;PPM1LB;OSBP;SERINC1;SGMS2;UGT8;PPM1L
Metabolic pathwaysSORD;IDO1;ALG6;ACAT1;PGLS;ACSL1A;PTDSS1A;CES1D;NTPCR
Sphingolipid signaling pathwayNRAS;CERS4;MAPK9;PLCB1;RAF1;PPP2R5E;PPP2R1A;PIK3R1;PLCB4

CERS2 has several biochemical functions, for example, DNA binding, protein binding, sphingosine N-acyltransferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CERS2 itself. We selected most functions CERS2 had, and list some proteins which have the same functions with CERS2. You can find most of the proteins on our site.

Function Related Protein
DNA bindingPBX3B;RBM5;LUC7L3;MEIS4.1A;ZNF726;RAD51B;MB21D1;ADNP2A;ARHGEF38
protein bindingSMOC1;CD48;PPP6R3;PAIP1;DSN1;CSTF3;DDX23;TGFB2;CSNK1E
sphingosine N-acyltransferase activityLASS1;CERS4;CERS2;LASS4;CERS5;LASS5;CERS4A;FAM57B;LASS2

CERS2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CERS2 here. Most of them are supplied by our site. Hope this information will be useful for your research of CERS2.

SLC22A1; ASGR1; ASGR2; ATP6V0C; HSP90AA1; 7242199; PSMD14; KIF1B; GABBR2; ARHGEF7; NDN

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