CES1
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Official Full Name
carboxylesterase 1
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Overview
This gene encodes a member of the carboxylesterase large family. The family members are responsible for the hydrolysis or transesterification of various xenobiotics, such as cocaine and heroin, and endogenous substrates with ester, thioester, or amide bonds. They may participate in fatty acyl and cholesterol ester metabolism, and may play a role in the blood-brain barrier system. This enzyme is the major liver enzyme and functions in liver drug clearance. Mutations of this gene cause carboxylesterase 1 deficiency. Three transcript variants encoding three different isoforms have been found for this gene. [provided by RefSeq, Jun 2010] -
Synonyms
CES1; carboxylesterase 1; CEH; REH; TGH; ACAT; CE-1; CES2; HMSE; SES1; HMSE1; PCE-1; hCE-1; liver carboxylesterase 1; egasyn; serine esterase 1; retinyl ester hydrolase; cocaine carboxylesterase; triacylglycerol hydrolase; carboxylesterase 2 (liver); brain carboxylesterase hBr1; cholesteryl ester hydrolase; monocyte/macrophage serine esterase; methylumbelliferyl-acetate deacetylase 1; acyl coenzyme A:cholesterol acyltransferase; acyl-coenzyme A:cholesterol acyltransferase; human monocyte/macrophage serine esterase 1; carboxylesterase 1 (monocyte/macrophage serine esterase 1);
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Assay Kits
- Cynomolgus Monkey
- Human
- Mouse
- E. coli
- E.coli
- HEK293
- HEK293T
- In Vitro Cell Free System
- Insect Cell
- Mammalian Cell
- Mammalian cells
- NS0
- Wheat Germ
- C
- 10×His
- His
- Flag
- GST
- His (Fc)
- Avi
- Myc
- DDK
- Myc|DDK
- N/A
- Involved Pathway
- Protein Function
- Interacting Protein
- CES1 Related Articles
- CES1 Related Research Area
CES1 involved in several pathways and played different roles in them. We selected most pathways CES1 participated on our site, such as Biological oxidations, Drug metabolism - other enzymes, E2F transcription factor network, which may be useful for your reference. Also, other proteins which involved in the same pathway with CES1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Biological oxidations | Sult2a2;COMT;SULT1C4;ADH7;CYP8B2;CYP2R1;SULT1ST6;ADH6;CYP21A2 |
| Drug metabolism - other enzymes | UGT1A4;HPRT1;UCK2A;ITPA;UGT1A7C;UGT2A1;TK1;XDH;NAT1 |
| E2F transcription factor network | E2F4;TRIM28;CDKN2C;UXT;MYBL2;RYBP;CEBPA;RBBP8;YY1 |
| Fluoropyrimidine Activity | SLC22A7;CES1;DPYS;DPYD;DHFR;TYMP;UPP2 |
| Metabolic pathways | ENO3;NAT8L;GNPDA2;HYAL6;SPTLC2A;ATP6V1G3;IMPDH2;ALDH18A1;PHOSPHO1 |
| Metabolism | KCNB1;SLCO1B1;SLC35D2;OSBP;DSEL;AZIN1A;SLC25A16;SLC5A4;MED22 |
| Phase 1 - Functionalization of compounds | CYP27B1;CYP3A7;CES1;CYP26A1;CYP2V1;CYP2AD6;CYP2R1;CYP2K8;CYP4F12 |
CES1 has several biochemical functions, for example, carboxylic ester hydrolase activity, methylumbelliferyl-acetate deacetylase activity, sterol esterase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CES1 itself. We selected most functions CES1 had, and list some proteins which have the same functions with CES1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| carboxylic ester hydrolase activity | NCEH1B;Ces2c;NCEH1;ACOT1;FAM135B;Ces2e;ACOT6;ACOT5;ABHD11 |
| methylumbelliferyl-acetate deacetylase activity | CES2;CES1;ESD |
| sterol esterase activity | LIPA;Cel;CES1D;CEL.1;CES3;CES1;CES5A |
| triglyceride lipase activity | PNPLA2;Cel;LIPC;PNLIPRP1;PNPLA4;LPL;LIPE;LIPCA;PNLIP |
CES1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CES1 here. Most of them are supplied by our site. Hope this information will be useful for your research of CES1.
CREB3
- Q&As
- Reviews
Q&As (7)
Ask a questionCES1 hydrolyzes ester and amide bonds in various compounds, including drugs, xenobiotics, and endogenous molecules.
CES1 is most abundantly expressed in the liver, playing a significant role in first-pass metabolism.
It metabolizes numerous ester-containing drugs, affecting their pharmacokinetics and pharmacodynamics.
CES1 is crucial for the activation of certain prodrugs, converting them into their active pharmacological forms.
Genetic variations in CES1 can lead to inter-individual differences in drug metabolism, impacting efficacy and toxicity.
Certain compounds can inhibit or activate CES1, altering the metabolism of its substrates.
It participates in the hydrolysis of triglycerides and cholesterol esters, contributing to lipid homeostasis.
Customer Reviews (3)
Write a reviewReliable for lab work.
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