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CES2

  • Official Full Name

    carboxylesterase 2

  • Overview

    This gene encodes a member of the carboxylesterase large family. The family members are responsible for the hydrolysis or transesterification of various xenobiotics, such as cocaine and heroin, and endogenous substrates with ester, thioester, or amide bonds. They may participate in fatty acyl and cholesterol ester metabolism, and may play a role in the blood-brain barrier system. The protein encoded by this gene is the major intestinal enzyme and functions in intestine drug clearance. Alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Oct 2010]
  • Synonyms

    CES2; carboxylesterase 2; iCE; CE-2; PCE-2; CES2A1; cocaine esterase; hCE-2; carboxylesterase 2 (intestine, liver); methylumbelliferyl-acetate deacetylase 2; intestinal carboxylesterase; liver carboxylesterase-2;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Rat
  • Zebrafish
  • BTI Insect Cell
  • E. coli
  • E.coli
  • HEK293
  • HEK293F
  • HEK293T
  • Human Cell
  • In Vitro Cell Free System
  • Mamanlian cells
  • Mammalian Cell
  • Mammalian cells
  • Wheat Germ
  • C
  • His
  • Flag
  • GST
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • Myc|DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human CES2-896H Active Recombinant Human CES2 E.coli N/A Gly25-Gln93
Human CES2-1140H Active Recombinant Human CES2 BTI Insect Cell N/A
Human CES2-1139H Active Recombinant Human CES2 protein(Met1-Leu559), His-tagged HEK293 C-His Met1-Leu559
Human CES2-1149H Recombinant Human CES2 Protein, GST-Tagged Wheat Germ GST
Human CES2-1141H Recombinant Human CES2, MYC/DDK-tagged HEK293 Myc/DDK
Human CES2-2139HCL Recombinant Human CES2 cell lysate Human Cell N/A
Human CES2-22H Active Recombinant Human CES2 Protein, His-tagged Mammalian cells His
Human CES2-749H Recombinant Human CES2 Protein, His-tagged HEK293F N-His Gln27-Leu559
Human CES2-107H Active Recombinant Human CES2 Protein E. coli
Human CES2-1726HFL Recombinant Full Length Human CES2, Flag-tagged Mamanlian cells Flag
Human CES2-4904H Recombinant Human CES2 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human CES2-4690H Recombinant Human CES2 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human CES2-3263HF Recombinant Full Length Human CES2 Protein, GST-tagged In Vitro Cell Free System GST 623 amino acids
Human CES2-750H Recombinant Human CES2 Protein, His-tagged E.coli N-His Leu452-Leu623
Human CES2-2661H-B Recombinant Human CES2 Protein Pre-coupled Magnetic Beads HEK293
Human CES2-2661H Recombinant Human CES2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human CES2-1040H Recombinant Human CES2 Protein (His452-Leu559), N-GST tagged E.coli N-GST His452-Leu559
Rat Ces2-751R Recombinant Rat Ces2 Protein, His-tagged E.coli N-His Ile352-Leu561
Zebrafish CES2-4641Z Recombinant Zebrafish CES2 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein

CES2 involved in several pathways and played different roles in them. We selected most pathways CES2 participated on our site, such as Drug metabolism - other enzymes, which may be useful for your reference. Also, other proteins which involved in the same pathway with CES2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Drug metabolism - other enzymesUCK2A;UPP2;DPYDB;UGT2A3;UGT2A2;NAT;Ces2e;UGT1AB;UGT5G1

CES2 has several biochemical functions, for example, carboxylic ester hydrolase activity, methylumbelliferyl-acetate deacetylase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CES2 itself. We selected most functions CES2 had, and list some proteins which have the same functions with CES2. You can find most of the proteins on our site.

Function Related Protein
carboxylic ester hydrolase activityNCEH1B;Ces2e;LIPH;ACOT10;ACOT9;CES1C;ABHD2B;ABHD4;ACOT5
methylumbelliferyl-acetate deacetylase activityCES1;ESD;CES2

CES2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CES2 here. Most of them are supplied by our site. Hope this information will be useful for your research of CES2.

ispH; 1-phosphatidyl-1d-myo-inositol 4,5-bisphosphate

  • Q&As
  • Reviews

Q&As (7)

Ask a question
What is the primary role of CES2 in drug metabolism? 06/23/2023

CES2, a carboxylesterase enzyme, is crucial in metabolizing various drugs by hydrolyzing ester and amide bonds.

How do genetic variations in CES2 affect drug efficacy and safety? 10/29/2022

Genetic variations in CES2 can lead to differences in drug metabolism, influencing treatment outcomes.

How does CES2 interact with other enzymes in the liver and gastrointestinal tract? 07/12/2022

CES2 collaborates with other metabolic enzymes, playing a role in the body's overall drug-processing capacity.

What role does CES2 play in the absorption and activation of prodrugs? 05/22/2022

CES2 is involved in activating prodrugs in the intestine, affecting their absorption and therapeutic action.

What potential therapeutic applications arise from targeting CES2 in personalized medicine? 10/24/2020

Understanding CES2 activity could aid in developing personalized treatment plans, optimizing drug efficacy and safety.

What is the impact of altered CES2 activity on pharmacokinetics? 10/12/2019

Altered CES2 activity can significantly affect the pharmacokinetics of drugs, altering their efficacy and toxicity.

How does CES2 contribute to the breakdown of ester and amide bonds in medications? 03/26/2018

It helps in the breakdown of drugs, facilitating their conversion into active or inactive metabolites.

Customer Reviews (3)

Write a review
Reviews
10/12/2022

    Exceptional support. Accelerates research timelines.

    05/03/2020

      Critical for research integrity. Integral to experiments.

      04/14/2020

        Timely and precise. Trusted for research milestones.

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