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CFI

  • Official Full Name

    complement factor I

  • Overview

    Complement factor I, also known as C3B/C4B inactivator, is a protein that in humans is encoded by the CFI gene. Complement Factor I (fI) is a protein of the complement system, first isolated in 1966 in guinea pig serum that regulates complement activation by cleaving cell-bound or fluid phase C3b and C4b.
  • Synonyms

    CFI; complement factor I; I factor (complement) , IF; C3b INA; C3b inactivator; FI; KAF; Konglutinogen activating factor; C3b-inactivator; C3B/C4B inactivator; complement component I; light chain of factor I; Konglutinogen-activating factor; complement fa;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Native Proteins
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Rat
  • E.coli
  • HEK293
  • HEK293T
  • Insect Cell
  • Mammalian cell
  • Mammalian Cell
  • Mammalian cells
  • Normal human serum (shown by certified tests to be negative for HBsAg, HTLV-I/II, STS and for antibodies to HCV, HIV-1 and HIV-II)
  • Flag
  • His
  • His (Fc)
  • Avi
  • Myc
  • His|GST
  • MYC
  • DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human CFI-290H Recombinant Human CFI protein, His-tagged E.coli His Ile340~Val583
Human CFI-9302H Recombinant Human CFI protein, His-tagged E.coli His Leu28~Gly243
Human CFI-2054H Recombinant Human CFI protein, His & GST-tagged E.coli His/GST Leu28~Gly243 (Accession # P05156)
Human CFI-7556HCL Recombinant Human CFI 293 Cell Lysate HEK293 N/A
Human CFI-1051H Recombinant Human CFI Protein (Lys19-Ile335), N-His tagged E.coli N-His Lys19-Ile335
Human CFI-105H Active Native Human Factor I Normal human serum (shown by certified tests to be negative for HBsAg, HTLV-I/II, STS and for antibodies to HCV, HIV-1 and HIV-II) N/A
Human CFI-1531HFL Recombinant Full Length Human CFI Protein, C-Flag-tagged Mammalian cells Flag
Human CFI-585H Recombinant Human CFI Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human CFI-585H-B Recombinant Human CFI Protein Pre-coupled Magnetic Beads HEK293
Mouse Cfi-2055M Recombinant Mouse Cfi protein, His-tagged E.coli His Arg358~Val603
Mouse CFI-3349M Recombinant Mouse CFI Protein Mammalian Cell His
Mouse Cfi-880M Recombinant Mouse Cfi Protein, MYC/DDK-tagged HEK293T MYC/DDK
Mouse Cfi-2210M Recombinant Mouse Cfi protein, His&Myc-tagged Insect Cell His&Myc 19-603aa
Mouse CFI-1613M Recombinant Mouse CFI Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Cfi-938M Recombinant Mouse Cfi protein, His&Myc-tagged Mammalian cell His&Myc 19-603aa
Mouse CFI-1613M-B Recombinant Mouse CFI Protein Pre-coupled Magnetic Beads HEK293
Mouse Cfi-1070M Recombinant Mouse Cfi protein, His&Myc-tagged HEK293 His&Myc 19-603aa
Rat CFI-1355R Recombinant Rat CFI Protein Mammalian Cell His
Rat Cfi-4998R Recombinant Rat Cfi protein, His&Myc-tagged HEK293 His&Myc 19-604aa
Rat CFI-1013R Recombinant Rat CFI Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat Cfi-2211R Recombinant Rat Cfi protein, His&Myc-tagged Insect Cell His&Myc 19-604aa
Rat CFI-1013R-B Recombinant Rat CFI Protein Pre-coupled Magnetic Beads HEK293
Chicken CFI-4700C Recombinant Chicken CFI Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • CFI Related Articles

CFI involved in several pathways and played different roles in them. We selected most pathways CFI participated on our site, such as Complement and coagulation cascades, Staphylococcus aureus infection, which may be useful for your reference. Also, other proteins which involved in the same pathway with CFI were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Complement and coagulation cascadesKNG1;CD59;MBL2;Serpina1b;SERPINE1;SERPINC1;MBL1;C2;CR2
Staphylococcus aureus infectionITGAL;H2-AB1;ICAM1;C4A;FCGR4;cgr2b;GM5077;HLA-DPB1;C1R

CFI has several biochemical functions, for example, metal ion binding, protein binding, scavenger receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CFI itself. We selected most functions CFI had, and list some proteins which have the same functions with CFI. You can find most of the proteins on our site.

Function Related Protein
metal ion bindingERCC2;BCL11AB;GTPBP8;VAV3B;ZNF189;NEK11;PMELA;IMPDH2;CSH2
protein bindingMT1A;KXD1;RPL27A;LRGUK;FBXO6;ILVBL;SELP;C9orf24;C20orf20
scavenger receptor activityCD5;SRCRB4D;LOXL4;LOXL3;TMPRSS4;CD163L1;CFI;TMPRSS15;SUSD2
serine-type endopeptidase activityPRTN3;IMMP2L;PREP;PCSK5;CFI;CTSC;TRY;GZMC;GZMA

CFI has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CFI here. Most of them are supplied by our site. Hope this information will be useful for your research of CFI.

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Szarvas, N; Szilagyi, A; et al. First-line therapy in atypical hemolytic uremic syndrome: consideration on infants with a poor prognosis. ITALIAN JOURNAL OF PEDIATRICS 40:-(2014).
Ardissino, G; Testa, S; et al. Discontinuation of Eculizumab Maintenance Treatment for Atypical Hemolytic Uremic Syndrome: A Report of 10 Cases. AMERICAN JOURNAL OF KIDNEY DISEASES 64:633-637(2014).
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