CFL2
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Official Full Name
cofilin 2 (muscle)
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Overview
This gene encodes an intracellular protein that is involved in the regulation of actin-filament dynamics. This protein is a major component of intranuclear and cytoplasmic actin rods. It can bind G- and F-actin in a 1:1 ratio of cofilin to actin, and it reversibly controls actin polymerization and depolymerization in a pH-dependent manner. Mutations in this gene cause nemaline myopathy type 7, a form of congenital myopathy. Alternative splicing results in multiple transcript variants. -
Synonyms
CFL2; cofilin 2 (muscle); cofilin-2; cofilin, muscle isoform; NEM7;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Chicken
- Human
- Mouse
- Rhesus Macaque
- Zebrafish
- E.coli
- HEK293
- HEK293T
- In Vitro Cell Free System
- Mammalian Cell
- Wheat Germ
- GST
- His
- His (Fc)
- Avi
- Myc
- DDK
- MYC
- N/A
- N
- Involved Pathway
- Protein Function
- Interacting Protein
CFL2 involved in several pathways and played different roles in them. We selected most pathways CFL2 participated on our site, such as Axon guidance, Caspase cascade in apoptosis, Fc gamma R-mediated phagocytosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with CFL2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Axon guidance | EFNA3;RGS3;CFL1;PSPN;SEMA3C;EFNA5;NRG3;SEMA3A;SEMA4A |
| Caspase cascade in apoptosis | SATB1;CASP2;DIABLO;TOP1;CASP4;DFFA;GAS2;CRADD;CFL2 |
| Fc gamma R-mediated phagocytosis | MAPK3;FCGR1A;PPAP2C;CDC42;SYK;WASL;LAT;PIK3R3;DOCK2 |
| G13 Signaling Pathway | RTKN;TNK2;CFL2;RHPN2;DIAPH1;GNA13;CIT;SH3RF1;MYBPH |
| Leptin signaling pathway | CFL2;KHDRBS1;IL1RN |
| Pertussis | C3;MAPK11;CALML3;ITGAM;RELA;IL12A;C4BPB;AMCF-II;NOS2 |
| Regulation of Actin Cytoskeleton | ITGB2L;BCAR1;FN1;ITGAM;CDC42;ITGA11A;KRAS;CDC42L;ARAF |
| Regulation of Microtubule Cytoskeleton | MARK1;TESK2;MAP1B;TPPP;MARK2;DPYSL2;CFL2 |
CFL2 has several biochemical functions, for example, actin binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CFL2 itself. We selected most functions CFL2 had, and list some proteins which have the same functions with CFL2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| actin binding | SPATA31;FHOD1;FMN2;ABLIM2;MYH7;CAPZA1;MICAL2B;EPB41L1;POF1B |
| protein binding | PLEKHF1;RNF113A;SLC35A2;KRTAP2-3;FTSJ3;TNFRSF6B;TPD52L2;NOMO2;SLC35F6 |
CFL2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CFL2 here. Most of them are supplied by our site. Hope this information will be useful for your research of CFL2.
ACTB; ACTG1; CSRP3; MAP3K3; CFL1; STK11; MYO1C; FLNA; MYH9; IQGAP1; CAPZA2; Tpm1; PPP1CB; GRB2; DBN1
- Q&As
- Reviews
Q&As (5)
Ask a questionIt's important to check current clinical trial databases for the latest information, but research exploring CFL2 as a therapeutic target is ongoing.
CFL2 is involved in maintaining the structure and function of cardiac muscle cells, and its dysregulation has been linked to conditions such as cardiomyopathies.
Research suggests that analyzing CFL2 levels and activity could serve as diagnostic markers for certain muscle-related disorders.
CFL2 interacts with actin and other regulatory proteins to modulate the dynamics of the actin cytoskeleton, influencing cellular processes crucial for muscle function.
Investigating CFL2 as a therapeutic target is an active area of research, with the aim of developing interventions for conditions characterized by impaired muscle function.
Customer Reviews (3)
Write a reviewIt has been extensively used in protein-protein interaction studies, enzymatic assays, and structural analyses, showcasing its reliability and adaptability in diverse research areas.
I am certain of obtaining reliable and reproducible results, enabling me to contribute to scientific progress and make new discoveries.
I highly recommend the CFL2 Protein for its outstanding performance in ELISA assays.
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