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CGA

  • Official Full Name

    glycoprotein hormones, alpha polypeptide

  • Overview

    The four human glycoprotein hormones chorionic gonadotropin (CG), luteinizing hormone (LH), follicle stimulating hormone (FSH), and thyroid stimulating hormone (TSH) are dimers consisting of alpha and beta subunits that are associated noncovalently. The alpha subunits of these hormones are identical, however, their beta chains are unique and confer biological specificity. The protein encoded by this gene is the alpha subunit and belongs to the glycoprotein hormones alpha chain family. Two transcript variants encoding different isoforms have been found for this gene.
  • Synonyms

    CGA; glycoprotein hormones, alpha polypeptide; HCG; LHA; FSHA; GPHa; TSHA; GPHA1; CG-ALPHA; glycoprotein hormones alpha chain; FSH-alpha; LSH-alpha; TSH-alpha; lutropin alpha chain; follitropin alpha chain; thyrotropin alpha chain; choriogonadotropin alph;

  • Transfected Stable Cell Lines
  • Native Proteins
  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Cynomolgus Monkey
  • Dog
  • Human
  • Mouse
  • Zebrafish
  • CHO
  • E.coli
  • HEK293
  • Human Cell
  • Human Pregancy Urine
  • In Vitro Cell Free System
  • Mammalian Cell
  • Urine
  • Wheat Germ
  • Yeast
  • Fc
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc
  • His|GST
  • mFc
  • N/A
  • Strep II
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human CGA-209H Human Chorionic Gonadotrophin, alpha subunit(purified) Reference standard N/A
Human CGA-8163H Native Human Chorionic Gonadotropin Human Pregancy Urine N/A
Human CGA-49H Recombinant Human CGA Yeast N/A
Human CGA-286H Recombinant Human CGA protein, His-tagged HEK293 His Ala25-Ser116
Human CGA-285H Recombinant Human CGA, Fc-tagged Human Cell Fc Met1-Ser116
Human CGA-224H Recombinant Human CGA, StrepII-tagged Human Cell Strep II 21-165, 145 a.a.
Human CGA-109H Recombinant Human Glycoprotein Hormones, Alpha Polypeptide CHO N/A
Human CGA-7786H Recombinant Human CGA protein, His & GST-tagged E.coli His/GST Ala25~Ser116 (Accession# P01215)
Human CGA-1182H Recombinant Human CGA Protein, GST-Tagged Wheat Germ GST
Human CGA-001HCL Recombinant Human CGA cell lysate Human Cell N/A
Human CGA-8356H Native Human CGA Urine N/A
Human CGA-190H Human Chorionic Gonadotrophin alpha subunit Reference standard N/A
Human CGA-60H Luteinizing Hormone alpha subunit Reference standard N/A
Human CGA-288H Recombinant Human CGA Protein, mFc-tagged HEK293 mFc Met1-Ser116
Human CGA-452H Recombinant Human CGA Protein (Met1-Ser116) HEK293 N/A Met1-Ser116
Human CGA-8162H Native Human Pregnancy Chorionic Gonadotropin Human Pregancy Urine N/A
Human CGA-01H Active Recombinant Human FSH alpha/beta Protein CHO Ala25-Ser116, Cys21-Glu129
Human CGA-3300HF Recombinant Full Length Human CGA Protein, GST-tagged In Vitro Cell Free System GST 116 amino acids
Human CGA-1855H Native Human, Glycoprotein Hormones, Alpha Polypeptide Human Pregancy Urine N/A
Human CGA-486H Recombinant Human CGA Protein 116
Mouse Cga-7787M Recombinant Mouse Cga protein, His-tagged E.coli His Leu25~Ser120 (Accession # P01216)
Dog CGA-1436D Recombinant Dog CGA protein, His-tagged Yeast His 25-120aa
Dog CGA-1364D Recombinant Dog CGA protein, His&Myc-tagged E.coli His&Myc 25-120aa
Cynomolgus Monkey CGA-404C Recombinant Cynomolgus CGA Protein, His-tagged Mammalian Cell His
Cynomolgus Monkey CGA-152C Recombinant Cynomolgus Monkey CGA Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Cynomolgus Monkey CGA-152C-B Recombinant Cynomolgus Monkey CGA Protein Pre-coupled Magnetic Beads HEK293
Zebrafish CGA-11710Z Recombinant Zebrafish CGA Mammalian Cell His
Chicken CGA-5303C Recombinant Chicken CGA Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • CGA Related Articles
  • CGA Related Research Area

CGA involved in several pathways and played different roles in them. We selected most pathways CGA participated on our site, such as Amine-derived hormones, Androgen biosynthesis, Autoimmune thyroid disease, which may be useful for your reference. Also, other proteins which involved in the same pathway with CGA were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Amine-derived hormonesTPH2;DIO2;CGA;DDC;DBH
Androgen biosynthesisPPP1R2;CYP17A1;CGA;POMCB
Autoimmune thyroid diseaseCTLA4;IFN-a;IL10;OSTN;CGA
Class A/1 (Rhodopsin-like receptors)INSL5;PROKR2;OPN1MW2;FPR-RS3;PMCH;EDNRAB;GPBAR1;ADORA3;GPR18
FSH signaling pathwayAREG;CGA;CYP19A1
G alpha (s) signalling eventsADCYAP1B;ADM2A;CALCA;POMCB;NPSR1;RLN3;PTH;SCT;ADCYAP1
GPCR downstream signalingPROKR1;NMS;NMBB;CHRM1;ADRA2A;EDNRAB;S1PR5B;OPN4.1;PTH2
GPCR ligand bindingGPR17;SETD6;KISS1;OXTRL;GPR77;CALCA;OPN1SW1;PTHLH;GPR120

CGA has several biochemical functions, for example, hormone activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CGA itself. We selected most functions CGA had, and list some proteins which have the same functions with CGA. You can find most of the proteins on our site.

Function Related Protein
hormone activityIFNT2;SST;FNDC5B;STC2A;GPHB5;CCL25;INS;IGF2A;IGF2B
protein bindingANGPT1;LRRC6;HIPK4;UBE2L6;RPS2;ZNF276;CCDC116;PPP2R5E;MC5R

CGA has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CGA here. Most of them are supplied by our site. Hope this information will be useful for your research of CGA.

FSHB; CGB; PTN; PTPN12

Glinicki, P; Jeske, W; et al. Comparison of chromogranin A (CgA) levels in serum and plasma (EDTA(2)K) and the respective reference ranges in healthy males. ENDOKRYNOLOGIA POLSKA 66:53-56(2015).
Ramirez, GA; Rodriguez, F; et al. Morphologic and immunohistochemical features of Merkel cells in the dog. RESEARCH IN VETERINARY SCIENCE 97:475-480(2014).
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