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CHI3L1

  • Official Full Name

    chitinase 3-like 1 (cartilage glycoprotein-39)

  • Overview

    Chitinases catalyze the hydrolysis of chitin, which is an abundant glycopolymer found in insect exoskeletons and fungal cell walls. The glycoside hydrolase 18 family of chitinases includes eight human family members. This gene encodes a glycoprotein member of the glycosyl hydrolase 18 family. The protein lacks chitinase activity and is secreted by activated macrophages, chondrocytes, neutrophils and synovial cells. The protein is thought to play a role in the process of inflammation and tissue remodeling. [provided by RefSeq, Sep 2009]
  • Synonyms

    CHI3L1; chitinase 3-like 1 (cartilage glycoprotein-39); GP39; ASRT7; GP-39; YKL40; CGP-39; YKL-40; YYL-40; HC-gp39; HCGP-3P; hCGP-39; chitinase-3-like protein 1; 39 kDa synovial protein; cartilage glycoprotein 39;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rat
  • Rhesus Macaque
  • CHO
  • E.coli
  • HEK293
  • HEK293 cells
  • Human Cell
  • In Vitro Cell Free System
  • Mammalian Cell
  • Mammalian cells
  • Wheat Germ
  • C
  • His
  • Myc
  • DDK
  • Flag
  • GST
  • His (Fc)
  • Avi
  • His|Myc
  • His|SUMO|Myc
  • His|T7
  • Myc|DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human CHI3L1-7262H Recombinant Human CHI3L1 protein, myc-His-tagged CHO His/Myc
Human CHI3L1-6990H Recombinant Human CHI3L1 protein, His & T7-tagged E.coli His/T7 Asn112~Lys377 (Accession # P36222)
Human CHI3L1-1232H Recombinant Human CHI3L1 Protein, GST-Tagged Wheat Germ GST
Human CHI3L1-1166H Recombinant Human CHI3L1 Protein, His-SUMO/MYC-tagged E.coli His/SUMO/Myc
Human CHI3L1-657H Recombinant Human CHI3L1 protein, His-tagged HEK293 His Tyr22-Thr383
Human CHI3L1-2521HCL Recombinant Human CHI3L1 cell lysate Human Cell N/A
Human CHI3L1-044H Recombinant Human CHI3L1 Protein, MYC/DDK-tagged, C13 and N15-labeled HEK293 C-Myc/DDK
Human CHI3L1-0001H Recombinant Human CHI3L1 Protein HEK293 cells
Human CHI3L1-11H Recombinant Human CHI3L1 Protein (Tyr22-Thr383), C-His tagged, Animal-free, Carrier-free E.coli C-His Tyr22-Thr383
Human CHI3L1-598H-B Recombinant Human CHI3L1 Protein Pre-coupled Magnetic Beads HEK293
Human CHI3L1-3195HF Recombinant Full Length Human CHI3L1 Protein, GST-tagged In Vitro Cell Free System GST 383 amino acids
Human CHI3L1-1716H Recombinant Human CHI3L1 Protein (Asn112-Lys377), His tagged E.coli His Asn112-Lys377
Human CHI3L1-598H Recombinant Human CHI3L1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human CHI3L1-3219H Recombinant Human CHI3L1 Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human CHI3L1-181H Recombinant Human CHI3L1 Protein, His-tagged HEK293 His 383
Human CHI3L1-774H Recombinant Human CHI3L1 Protein, His-tagged E.coli N-His Asn112-Lys377
Human CHI3L1-347HFL Active Recombinant Full Length Human CHI3L1 Protein, C-Flag-tagged Mammalian cells Flag
Mouse Chi3l1-6906M Recombinant Mouse Chi3l1 protein, His-tagged HEK293 His Met1-Ala381
Mouse CHI3L1-1715MCL Recombinant Mouse CHI3L1 cell lysate Human Cell N/A
Rat CHI3L1-1370R Recombinant Rat CHI3L1 Protein Mammalian Cell His
Rat Chi3l1-1375R Recombinant Rat Chi3l1 protein, His-tagged E.coli His Tyr117~Lys364
Rat Chi3l1-1238R Recombinant Rat Chi3l1 protein, His&Myc-tagged E.coli His&Myc 20-381aa
Rat CHI3L1-1028R-B Recombinant Rat CHI3L1 Protein Pre-coupled Magnetic Beads HEK293
Rat Chi3l1-5874R Recombinant Rat Chi3l1 protein, His-tagged E.coli His 20-381aa
Rat CHI3L1-1028R Recombinant Rat CHI3L1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque CHI3L1-844R Recombinant Rhesus monkey CHI3L1 Protein, His-tagged Mammalian Cell His
Rhesus Macaque CHI3L1-670R-B Recombinant Rhesus Macaque CHI3L1 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque CHI3L1-670R Recombinant Rhesus Macaque CHI3L1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • CHI3L1 Related Articles
  • CHI3L1 Related Research Area

CHI3L1 involved in several pathways and played different roles in them. We selected most pathways CHI3L1 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with CHI3L1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein

CHI3L1 has several biochemical functions, for example, carbohydrate binding, chitin binding, NOT chitinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CHI3L1 itself. We selected most functions CHI3L1 had, and list some proteins which have the same functions with CHI3L1. You can find most of the proteins on our site.

Function Related Protein
carbohydrate bindingChil3;LMAN2;GALNT13;OLR1;MBL1;GANAB;CLEC5A;KLRC2;LGALS9
chitin bindingCTBS;CHID1;Chil3;FIBCD1;CHIA.3;CHIT1;CHIA.1;CHIA.4;CHI3L1
NOT chitinase activityCHI3L1;Chil3;CHI3L2
extracellular matrix structural constituentCOL11A1B;COL11A1A;COL2A1B;COL5A2;CD4;PXDN;MATN3;FBLN1;TFPI2

CHI3L1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CHI3L1 here. Most of them are supplied by our site. Hope this information will be useful for your research of CHI3L1.

Zhang, JP; Yuan, HX; et al. Increased expression of Chitinase 3-like 1 and microvessel density predicts metastasis and poor prognosis in clear cell renal cell carcinoma. TUMOR BIOLOGY 35:12131-12137(2014).
Bonella, F; Costabel, U; et al. Biomarkers in Connective Tissue Disease-Associated Interstitial Lung Disease. SEMINARS IN RESPIRATORY AND CRITICAL CARE MEDICINE 35:181-200(2014).
  • Q&As
  • Reviews

Q&As (6)

Ask a question
Is there any other mode of action for CHI3L1? 01/05/2022

In addition to being involved in cartilage metabolism and immune regulation, CHI3L1 may also have other modes of action, such as regulating cell adhesion and migration.

What is the role of CHI3L1 in immune regulation? 07/11/2021

This protein can act as an immunomodulator to inhibit the inflammatory response and the activity of immune cells, thereby maintaining the balance of the immune system.

Does CHI3L1 involved in the metabolism and repair of cartilage? 04/15/2021

CHI3L1 can bind to receptors on the surface of chondrocytes, stimulate the proliferation and differentiation of chondrocytes, and promote cartilage synthesis and repair.

How is the expression level of CHI3L1 regulated? 03/20/2021

The expression level of CHI3L1 is regulated by a variety of factors, including transcription factors, signal transduction pathways, and epigenetic modifications.

What is the association between CHI3L1 and joint diseases such as rheumatoid arthritis? 04/26/2020

In joint diseases such as rheumatoid arthritis, the expression level of CHI3L1 may be abnormally elevated, promoting inflammation and joint damage, and aggravating the condition.

How to detect the expression level of CHI3L1? 12/16/2019

The expression level of CHI3L1 can be detected by immunohistochemistry, western blotting, and real-time PCR.

Customer Reviews (3)

Write a review
Reviews
12/15/2022

    CHI3L1 has strong biological activity combined with its high purity makes its experimental results extremely reliable.

    10/22/2022

      The band strength in Western blot was high, which improved the signal-to-noise ratio of the experiment.

      10/24/2021

        It can simplify the complex chemical reaction and improve the high yield, shorten the experimental time.

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