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CHKA

Official Full Name

choline kinase alpha
Overview

The major pathway for the biosynthesis of phosphatidylcholine occurs via the CDP-choline pathway. The protein encoded by this gene is the initial enzyme in the sequence and may play a regulatory role. The encoded protein also catalyzes the phosphorylation of ethanolamine. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Synonyms

CHKA; choline kinase alpha; CK; EK; CHK; CKI; CHETK-alpha; ethanolamine kinase;

Type

Recombinant Proteins
Cell & Tissue Lysates
Protein Pre-coupled Magnetic Beads

Species

Human
Mouse
P.falciparum
Rat
Zebrafish

Source

E.coli
HEK293
HEK293T
In Vitro Cell Free System
Mamanlian cells
Mammalian Cell
Wheat Germ

Tag

Flag
GST
His
His (Fc)
Avi
His|GST
Myc
DDK
MYC
Myc|DDK
N/A

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	CHKA-65H	Recombinant Human CHKA, MYC/DDK-tagged	HEK293	Myc/DDK		Inquiry
Human	CHKA-26903TH	Recombinant Human CHKA	Wheat Germ	N/A	457 amino acids	Inquiry
Human	CHKA-5269H	Recombinant Human CHKA Protein	E.coli	N/A		Inquiry
Human	CHKA-1240H	Recombinant Human CHKA Protein, GST-Tagged	Wheat Germ	GST		Inquiry
Human	CHKA-7535HCL	Recombinant Human CHKA 293 Cell Lysate	HEK293	N/A		Inquiry
Human	CHKA-8874HFL	Recombinant Full Length Human CHKA, Flag-tagged	Mamanlian cells	Flag		Inquiry
Human	CHKA-5412H	Recombinant Human CHKA Protein, Myc/DDK-tagged, C13 and N15-labeled	HEK293T	Myc/DDK		Inquiry
Human	CHKA-3201HF	Recombinant Full Length Human CHKA Protein, GST-tagged	In Vitro Cell Free System	GST	457 amino acids	Inquiry
Human	CHKA-77HF	Recombinant Full Length Human CHKA Protein	In Vitro Cell Free System		457 amino acids	Inquiry
Mouse	Chka-889M	Recombinant Mouse Chka Protein, MYC/DDK-tagged	HEK293T	MYC/DDK		Inquiry
Mouse	Chka-1659M	Recombinant Mouse Chka protein, His & GST-tagged	E.coli	His/GST	Met1~Glu250 (Accession # O54804)	Inquiry
Rat	CHKA-1373R	Recombinant Rat CHKA Protein	Mammalian Cell	His		Inquiry
Rat	CHKA-1031R	Recombinant Rat CHKA Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Rat	CHKA-1031R-B	Recombinant Rat CHKA Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
P.falciparum	CHKA-5270P	Recombinant P. falciparum CHKA Protein	E.coli	N/A		Inquiry
Zebrafish	CHKA-3986Z	Recombinant Zebrafish CHKA	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein
CHKA Related Articles

CHKA involved in several pathways and played different roles in them. We selected most pathways CHKA participated on our site, such as Acetylcholine Synthesis, Choline metabolism in cancer, Glycerophospholipid biosynthesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with CHKA were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Acetylcholine Synthesis	CHKA;PEMT;CHAT
Choline metabolism in cancer	PIK3R1;DGKZ;PPAP2C;PDPK1;TAE1;NRAS;SLC22A3;CHKA;HRAS
Glycerophospholipid biosynthesis	AGPAT2;DGAT1B;CPNE3;CEPT1A;SLC44A5B;AWAT2;CPNE6;PLBD1;STIL
Glycerophospholipid metabolism	TAE1;LPCAT4;PLA2G5;MBOAT2;CEPT1B;LCLAT1;AGPAT5;PLA2G16;CHKA
Metabolic pathways	MTMR14;HPDB;SYNJ2;GMPPB;ATP5B;NDUFA4L2;NDUFA3;PGAM1B;CYP2C39
Metabolism	PDZD11;SULT2ST2;CYP11B1;DGAT1B;MED6;COX7C;NUDT15;MED26;ACER1
Metabolism of lipids and lipoproteins	AGPAT6;PHOSPHO1;CSNK1G2;FAAH2;CPNE6;ABHD4;MED7;MED18;SACM1L
Phospholipid metabolism	PTPMT1;PITPNB;PEMT;ABHD3;CDS1;AWAT2;SACM1LB;PNPLA8;PLD6

CHKA has several biochemical functions, for example, ATP binding, choline binding, choline kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CHKA itself. We selected most functions CHKA had, and list some proteins which have the same functions with CHKA. You can find most of the proteins on our site.

Function	Related Protein
ATP binding	ACSF3;SLFN5;UBE2E1;EPHB1;PDXK;HSPA1A;AURKA;NEK8;MCM2
choline binding	CRP;SLC5A7;CHKA;BCHE
choline kinase activity	CHKB;CHKA
cholinesterase activity	BCHE;CELL;CEL.1;ACHE;CHKA
drug binding	DHFR;SIGMAR1;PIGC;DHODH;PYGM;PPP3CB;PYGB;PDE4C;CHRM1
ethanolamine kinase activity	CHKB;CHKA;ETNK1;ETNK2
protein homodimerization activity	JAM3;GRM6;IKZF4;IMPA1;ALS2;TENM3;MAP3K9;PDGFA;IGJ
signal transducer activity	VMN1R44;HCAR1-1;TAAR12F;DRD1B;CCR9A;DRD2L;PLCXD2;MRGPRH;ACKR3B

CHKA has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CHKA here. Most of them are supplied by our site. Hope this information will be useful for your research of CHKA.

FCHSD2

Kalashnyk, O; Lykhmus, O; et al. alpha 7 Nicotinic acetylcholine receptor-specific antibody stimulates interleukin-6 production in human astrocytes through p38-dependent pathway. INTERNATIONAL IMMUNOPHARMACOLOGY 23:475-479(2014).

Gaillard, F; Kuny, S; et al. Retinal distribution of Disabled-1 in a diurnal murine rodent, the Nile grass rat Arvicanthis niloticus. EXPERIMENTAL EYE RESEARCH 125:236-243(2014).