CHMP2A
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Official Full Name
charged multivesicular body protein 2A
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Overview
CHMP2A belongs to the chromatin-modifying protein/charged multivesicular body protein (CHMP) family. These proteins are;components of ESCRT-III (endosomal sorting complex required for transport III), a complex involved in degradation of;surface receptor proteins and formation of endocytic multivesicular bodies (MVBs). Some CHMPs have both nuclear and;cytoplasmic/vesicular distributions, and one such CHMP, CHMP1A (MIM 164010), is required for both MVB formation and;regulation of cell cycle progression (Tsang et al., 2006 (PubMed 16730941)). -
Synonyms
CHMP2A; charged multivesicular body protein 2A; chromatin modifying protein 2A; BC 2; CHMP2; putative breast adenocarcinoma marker (32kD); VPS2; VPS2 homolog A (S. cerevisiae); VPS2A; BC2; hVps2 1; putative breast adenocarcinoma marker; Putative breast adenocarcinoma marker BC2; Vacuolar protein sorting associated protein 2 1; Vps2 1; vps2-1; hVps2-1; VPS2 homolog A; chromatin-modifying protein 2a; putative breast adenocarcinoma marker BC-2; vacuolar protein sorting-associated protein 2-1; BC-2;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Chicken
- Human
- Mouse
- Rhesus Macaque
- E.coli
- HEK293
- HEK293T
- In Vitro Cell Free System
- Mammalian Cell
- Wheat Germ
- GST
- His
- His (Fc)
- Avi
- Myc
- DDK
- N/A
- Involved Pathway
- Protein Function
- Interacting Protein
CHMP2A involved in several pathways and played different roles in them. We selected most pathways CHMP2A participated on our site, such as Endocytosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with CHMP2A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Endocytosis | ASAP2A;ARPC5A;ARF5;CSF1RA;IQSEC3;RHOAA;SNX3;ARPC5LB;RNF103-CHMP3 |
CHMP2A has several biochemical functions, for example, phosphatidylcholine binding, protein binding, protein domain specific binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CHMP2A itself. We selected most functions CHMP2A had, and list some proteins which have the same functions with CHMP2A. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| phosphatidylcholine binding | GPR119;APOC1;APOA4B.1;ESYT2;APOA1;ALDOB;CHMP2A;APOA4B.2;VPS24 |
| protein binding | RNF41;IKBKB;BANF1;LCMT2;FUBP1;OSBPL6;PDS5B;PNOC;GRB2 |
| protein domain specific binding | MRPL17;FOXA1;DVL2;PPARA;HIST1H4D;ARL1;GSN;PLXND1;VPS4A |
CHMP2A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CHMP2A here. Most of them are supplied by our site. Hope this information will be useful for your research of CHMP2A.
DOCK8; USP8; USP54; PCBD1; TGFB3; E2F4; 1-phosphatidyl-1d-myo-inositol 3,5-bisphosphate; pi3p; midostaurin; Ring1; ATP6AP2; VCAM1; Rab5c; Vps4b; RAB5C
- Q&As
- Reviews
Q&As (5)
Ask a questionResearch into potential therapies targeting CHMP2A is ongoing, but no specific treatments have been approved yet.
CHMP2A is involved in the autophagic process by helping in the formation of autophagosomes and lysosome fusion, which is essential for cellular recycling.
Dysfunction in CHMP2A can disrupt cellular homeostasis by impairing the proper sorting and degradation of cellular components, leading to cellular stress.
CHMP2A mutations can be detected in some cases of hereditary spastic paraplegia, but it's not commonly used as a diagnostic marker for other neurodegenerative diseases.
CHMP2A plays a role in antigen presentation, and its dysfunction could impact the immune response.
Customer Reviews (3)
Write a reviewSuch manufacturer support fosters a conducive environment for successful and impactful research outcomes.
By considering these advantages and the supportive role of manufacturers, researchers studying CHMP2A protein can benefit from high-quality products, technical assistance, customization options, product validation, and potential collaborations.
This information ensures that researchers have a clear understanding of the product's performance attributes, and enables them to select the most suitable protein preparation for their experiments.
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