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CHN2

  • Official Full Name

    chimerin (chimaerin) 2

  • Overview

    This gene is a member of the chimerin family and encodes a protein with a phorbol-ester/DAG-type zinc finger, a Rho-GAP domain and an SH2 domain. This protein has GTPase-activating protein activity that is regulated by phospholipid binding and binding of diacylglycerol (DAG) induces translocation of the protein from the cytosol to the Golgi apparatus membrane. The protein plays a role in the proliferation and migration of smooth muscle cells. Decreased expression of this gene is associated with high-grade gliomas and breast tumors, and increased expression of this gene is associated with lymphomas. Mutations in this gene have been associated with schizophrenia in men. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
  • Synonyms

    CHN2; chimerin (chimaerin) 2; beta-chimaerin; ARHGAP3; beta chimerin; RhoGAP3; beta-chimerin; beta3-chimaerin; rho-GTPase-activating protein 3; BCH; CHN2-3; MGC138360;

  • Cell & Tissue Lysates
  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rat
  • Rhesus Macaque
  • E.coli
  • HEK293
  • HEK293T
  • Mammalian Cell
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human CHN2-7528HCL Recombinant Human CHN2 293 Cell Lysate HEK293 N/A
Human CHN2-663H Recombinant Human CHN2 Protein, His-tagged E.coli His Met1~Cys264
Human CHN2-1486H Recombinant Human CHN2 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Mouse Chn2-664M Recombinant Mouse Chn2 Protein, His-tagged E.coli His Gly101~Ile323
Mouse Chn2-2152M Recombinant Mouse Chn2 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Rat CHN2-1379R Recombinant Rat CHN2 Protein Mammalian Cell His
Rat CHN2-1037R-B Recombinant Rat CHN2 Protein Pre-coupled Magnetic Beads HEK293
Rat CHN2-1037R Recombinant Rat CHN2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat Chn2-665R Recombinant Rat Chn2 Protein, His-tagged E.coli His Val101~Gln280
Rhesus Macaque CHN2-853R Recombinant Rhesus monkey CHN2 Protein, His-tagged Mammalian Cell His
Rhesus Macaque CHN2-679R-B Recombinant Rhesus Macaque CHN2 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque CHN2-679R Recombinant Rhesus Macaque CHN2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • CHN2 Related Articles

CHN2 involved in several pathways and played different roles in them. We selected most pathways CHN2 participated on our site, such as ErbB1 downstream signaling, Regulation of RAC1 activity, Rho GTPase cycle, which may be useful for your reference. Also, other proteins which involved in the same pathway with CHN2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
ErbB1 downstream signalingACTR2;ABI1;NCKAP1;BAIAP2;MAP3K2;ARF4;CHN2;ACTR3;EPS8
Regulation of RAC1 activityCHN1;ARHGAP1;RAP1GDS1;RALBP1;ABR;ARHGAP9;DOCK6;PREX2;ARHGAP17
Rho GTPase cycleARHGAP10;ARAP1;ARHGAP36;ARHGAP26;ARHGAP6;ARHGEF17;ARHGEF18A;CHN1;ECT2
Signal TransductionAKR1C6;RGS14;DNAL4B;FAM105B;NMS;ARHGAP12;RLN2;PROKR1;FSTL1
Signaling by Rho GTPasesWIPF3;RHOJ;ARAP1;STARD8;ARHGAP1;RHPN2;CHN2;DCLRE1B;IQGAP3

CHN2 has several biochemical functions, for example, GTPase activator activity, SH3/SH2 adaptor activity, metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CHN2 itself. We selected most functions CHN2 had, and list some proteins which have the same functions with CHN2. You can find most of the proteins on our site.

Function Related Protein
GTPase activator activityARHGAP28;RACGAP1;RGS12;AXIN1;RIC8B;ARHGEF6;RASA4;RABEP2;ARHGAP33
SH3/SH2 adaptor activityLASP1;SKAP2;LAT;ARHGAP4;SH2D3A;ARHGAP1;GAB1;GRB10;NCK1
metal ion bindingAKAP8L;POLM;SPRTN;SNAI1A;MMP14A;ZFP668;GNAI3;MCEE;BLF
protein bindingMFN2;H2AFX;DGCR8;NEDD4;BCL2L12;BNIP3;DCSTAMP;LRRK1;WWOX

CHN2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CHN2 here. Most of them are supplied by our site. Hope this information will be useful for your research of CHN2.

RAC1; ERBB3; RB1; BAG6; SUMO2; SMARCD1; TP53RK; RANBP3

Scharfstein, J; Schmitz, V; et al. Host cell invasion by Trypanosoma cruzi is potentiated by activation of bradykinin B-2 receptors. JOURNAL OF EXPERIMENTAL MEDICINE 192:1289-1299(2000).
Yoshizaki, N; Yonezawa, S; et al. Cysteine proteinase plays a key role for the initiation of yolk digestion during development of Xenopus laevis. DEVELOPMENT GROWTH & DIFFERENTIATION 40:659-667(1998).
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