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CHRM1

  • Official Full Name

    cholinergic receptor, muscarinic 1

  • Overview

    The muscarinic cholinergic receptors belong to a larger family of G protein-coupled receptors. The functional diversity of these receptors is defined by the binding of acetylcholine and includes cellular responses such as adenylate cyclase inhibition, phosphoinositide degeneration, and potassium channel mediation. Muscarinic receptors influence many effects of acetylcholine in the central and peripheral nervous system. The muscarinic cholinergic receptor 1 is involved in mediation of vagally-induced bronchoconstriction and in the acid secretion of the gastrointestinal tract. The gene encoding this receptor is localized to 11q13.
  • Synonyms

    Cholinergic receptor muscarinic 1; CHRM1; HM1; M1; Muscarinic acetylcholine receptor M1; cholinergic receptor, muscarinic 1; OTTHUMP00000236792; M1R; MGC30125; Muscarinic M1 Receptor;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Assay Kits
  • Homo sapiens (Human)
  • Human
  • Macaca mulatta (Rhesus macaque)
  • Mouse
  • Mus musculus (Mouse)
  • Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
  • Rat
  • Rhesus Macaque
  • Sus scrofa (Pig)
  • E.coli
  • E.coli expression system
  • HEK293
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • Yeast
  • His
  • His (Fc)
  • Avi
  • Flag
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human CHRM1-11205H Recombinant Human CHRM1, His-tagged E.coli His 210-359a.a.
Human CHRM1-1269H Recombinant Human CHRM1 Protein Wheat Germ N/A
Human CHRM1-7521HCL Recombinant Human CHRM1 293 Cell Lysate HEK293 N/A
Human CHRM1-1093HFL Recombinant Human CHRM1 protein, His&Flag-tagged HEK293 His&Flag 1-460 aa
Human CHRM1-3220HF Recombinant Full Length Human CHRM1 Protein In Vitro Cell Free System 458 amino acids
Mouse CHRM1-3424M Recombinant Mouse CHRM1 Protein Mammalian Cell His
Mouse CHRM1-1658M-B Recombinant Mouse CHRM1 Protein Pre-coupled Magnetic Beads HEK293
Mouse CHRM1-1658M Recombinant Mouse CHRM1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat Chrm1-5696R Recombinant Rat Chrm1 protein, His-tagged E.coli His Arg210~Ala363 (Accession # P08482)
Rat CHRM1-1385R Recombinant Rat CHRM1 Protein Mammalian Cell His
Rat Chrm1-776R Recombinant Rat Chrm1 Protein, His-tagged E.coli N-His Ser356-Cys460
Rat CHRM1-1361R Recombinant Rat CHRM1 Protein (210-366 aa), His-tagged Yeast His 210-366 aa
Rat Chrm1-777R Recombinant Rat Chrm1 Protein, His-tagged E.coli N-His Ser356-Cys460
Rat CHRM1-1043R-B Recombinant Rat CHRM1 Protein Pre-coupled Magnetic Beads HEK293
Rat Chrm1-2693R Recombinant Rat Chrm1 protein, His-tagged E.coli His 210-366aa
Rat CHRM1-1043R Recombinant Rat CHRM1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Homo sapiens (Human) RFL24048HF Recombinant Full Length Human Muscarinic Acetylcholine Receptor M1(Chrm1) Protein, His-Tagged E.coli expression system His Full Length (1-460)
Macaca mulatta (Rhesus macaque) RFL21133MF Recombinant Full Length Macaca Mulatta (Rhesus Macaque) Muscarinic Acetylcholine Receptor M1(Chrm1) Protein, His-Tagged E.coli expression system His Full Length (1-460)
Mus musculus (Mouse) RFL32833MF Recombinant Full Length Mouse Muscarinic Acetylcholine Receptor M1(Chrm1) Protein, His-Tagged E.coli expression system His Full Length (1-460)
Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) RFL10923PF Recombinant Full Length Pongo Abelii Muscarinic Acetylcholine Receptor M1(Chrm1) Protein, His-Tagged E.coli expression system His Full Length (1-460)
Rhesus Macaque CHRM1-859R Recombinant Rhesus monkey CHRM1 Protein, His-tagged Mammalian Cell His
Rhesus Macaque CHRM1-685R-B Recombinant Rhesus Macaque CHRM1 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque CHRM1-685R Recombinant Rhesus Macaque CHRM1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Sus scrofa (Pig) RFL31303SF Recombinant Full Length Pig Muscarinic Acetylcholine Receptor M1(Chrm1) Protein, His-Tagged E.coli expression system His Full Length (1-460)
Kit-1165 CHRM1 Activated GPCR Internalization Assay Kit N/A
Kit-1006 Cell Migration/Chemotaxis Assay Kit (24-well, 3 μm) N/A
Kit-1166 CHRM1 U2OS β-Arrestin GPCR Assay Kit N/A
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • CHRM1 Related Research Area

CHRM1 involved in several pathways and played different roles in them. We selected most pathways CHRM1 participated on our site, such as Amine ligand-binding receptors, Calcium Regulation in the Cardiac Cell, Calcium signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with CHRM1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Amine ligand-binding receptorsADRA2C;DRD3;CHRM3;CHRM5;DRD2;ADRA1D;ADRa1A;TAAR1;CHRM1
Calcium Regulation in the Cardiac CellRGS11;RGS7;GNG13B;GJB5;CX55.5;GJB6;GJA3;RGS5;GNB3B
Calcium signaling pathwayPHKG1B;HTR6;SLC8A2;PLCZ1;ITPKB;GRIN2C;GRM1;CALML3;PRKCBA
Cholinergic synapseCHRNB4;CAMK2A;KCNQ2;CHRM3;GNAI1;GNAO1;FYN;CHRM4;PRKCG
Class A/1 (Rhodopsin-like receptors)RGS1;NMBA;CHRM3;PROK2;QRFP;CHRM1;PYYA;TRH;GPR31B
G alpha (q) signalling eventsCASR;LPAR2A;UTS2;AGTR1;UTS2D;NPS;NMS;EDN1;OPN4B
GPCR downstream signalingCXCL13;GPR55;ADRA2C;CCR1;TRPC6A;OPN1LW1;OXGR1;RGS4;INSL3
GPCR ligand bindingFZD10;GPBAR1;PENKB;RLN2;CRHB;CRHR2;GPR39;PNOC;GPR31B

CHRM1 has several biochemical functions, for example, G-protein coupled acetylcholine receptor activity, drug binding, phosphatidylinositol phospholipase C activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CHRM1 itself. We selected most functions CHRM1 had, and list some proteins which have the same functions with CHRM1. You can find most of the proteins on our site.

Function Related Protein
G-protein coupled acetylcholine receptor activityCHRM4;CHRM2;CHRM1;CHRM3;CHRM5;CHRM5A;CHRM2A;CHRM5B
drug bindingCHKA;DHFR;CHRNB3;HTR2B;CHRNB4;HTR2C;PPARD;FOLR1;CHRM2
phosphatidylinositol phospholipase C activityPLCD3;PLCD4;CHRM3;PLD4;CASR;PLCB2;CHRM1;PLCL1;PLCH1

CHRM1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CHRM1 here. Most of them are supplied by our site. Hope this information will be useful for your research of CHRM1.

Dlg4; GPRASP1; GPRASP2; pirenzepine/gastrozepin; ARRB2; ARRB1

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