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CHST4

Official Full Name

carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 4
Overview

This gene encodes an N-acetylglucosamine 6-O sulfotransferase. The encoded enzyme transfers sulfate from 3phosphoadenosine 5phospho-sulfate to the 6-hydroxyl group of N-acetylglucosamine on glycoproteins. This protein is localized to the Golgi and is involved in the modification of glycan structures on ligands of the lymphocyte homing receptor L-selectin. Alternate splicing in the 5 UTR results in multiple transcript variants that encode the same protein.
Synonyms

CHST4; carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 4; carbohydrate sulfotransferase 4; HEC GLCNAC 6 ST; LSST; Carbohydrate (N acetylglucosamine 6-O) sulfotransferase 4; Galactose/N acetylglucosamine/N acetylglucosamine 6 O sulfotransferase 3; GlcNAc6ST 2; GST 3; HEC GlcNAc6ST; High endothelial cells N acetylglucosamine 6 O sulfotransferase; L selectin ligand sulfotransferase; N acetylglucosamine 6 O sulfotransferase; GST-3; gn6st-2; glcNAc6ST-2; HEC-GlcNAc6ST; OTTHUMP00000174926; L-selectin ligand sulfotransferase; N-acetylglucosamine 6-O-sulfotransferase 2; high endothelial cells N-acetylglucosamine 6-O-sulfotransferase; galactose/N-acetylglucosamine/N-acetylglucosamine 6-O-sulfotransferase 3; galactose/N-acetylglucosamine/N-acetylgalactosamine 6-O-sulfotransferase 3; GST3; GlcNAc6ST2; HECGLCNAC6ST;

Type

Recombinant Proteins
Protein Pre-coupled Magnetic Beads

Species

Human
Mouse

Source

CHO
E.coli
HEK293
In Vitro Cell Free System
Mammalian Cell
Wheat Germ

Tag

GST
His
His (Fc)
Avi

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	CHST4-561H	Active Recombinant Human CHST4 Protein, His-tagged	CHO	His	His29-His386	Inquiry
Human	CHST4-11230H	Recombinant Human CHST4, His-tagged	E.coli	His	C-term-310a.a.	$319 / 25ug
Human	CHST4-1344H	Recombinant Human CHST4 Protein, GST-tagged	Wheat Germ	GST		Inquiry
Human	CHST4-3227H	Recombinant Human CHST4 protein, His-tagged	E.coli	His	177-386 aa	$319 / 25ug
Human	CHST4-1835HF	Recombinant Full Length Human CHST4 Protein, GST-tagged	In Vitro Cell Free System	GST	370 amino acids	Inquiry
Mouse	CHST4-3453M	Recombinant Mouse CHST4 Protein	Mammalian Cell	His		Inquiry
Mouse	CHST4-1676M-B	Recombinant Mouse CHST4 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Mouse	CHST4-1676M	Recombinant Mouse CHST4 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry

Involved Pathway
Protein Function
Interacting Protein

CHST4 involved in several pathways and played different roles in them. We selected most pathways CHST4 participated on our site, such as Glycosaminoglycan biosynthesis - keratan sulfate, metapathway biotransformation, which may be useful for your reference. Also, other proteins which involved in the same pathway with CHST4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Glycosaminoglycan biosynthesis - keratan sulfate	ST3GAL2;B3GNT7;CHST4;CHST1;Chst5;B3GNT2B;B3GNT2;ST3GAL3;B4GALT2
metapathway biotransformation	NAA30;NAA50;KCNAB3;NAA40;NAT8;HS3ST6;SULT4A1;SULT1C2;CEACAM21

CHST4 has several biochemical functions, for example, N-acetylglucosamine 6-O-sulfotransferase activity, sulfotransferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CHST4 itself. We selected most functions CHST4 had, and list some proteins which have the same functions with CHST4. You can find most of the proteins on our site.

Function	Related Protein
N-acetylglucosamine 6-O-sulfotransferase activity	SULT1ST6;HS3ST3B1B;CHST4;Sult3a1;CHST7;SULT3ST3;HS6ST1B;SULT2ST2;CHST3B
sulfotransferase activity	HS6ST1B;CHST2;HS2ST1A;CHST12A;HS3ST3B1B;DSEL;SULT2A1;HS3ST1;SULT1C4

CHST4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CHST4 here. Most of them are supplied by our site. Hope this information will be useful for your research of CHST4.

DCPS