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CIRH1A

Official Full Name

cirrhosis, autosomal recessive 1A (cirhin)
Overview

This gene encodes a WD40-repeat-containing protein that is localized to the nucleolus. Mutation of this gene causes North American Indian childhood cirrhosis, a severe intrahepatic cholestasis that results in transient neonatal jaundice, and progresses to periportal fibrosis and cirrhosis in childhood and adolescence.
Synonyms

CIRH1A; cirrhosis, autosomal recessive 1A (cirhin); cirhin; FLJ14728; KIAA1988; NAIC; TEX292; UTP4; small subunit (SSU) processome component; homolog (yeast); FLJ17146; testis expressed gene 292; UTP4, small subunit (SSU) processome component, homolog;

Type

Recombinant Proteins
Protein Pre-coupled Magnetic Beads

Species

Human
Mouse
Zebrafish

Source

E.coli
HEK293
In Vitro Cell Free System
Mammalian Cell
Wheat Germ

Tag

GST
His
His (Fc)
Avi

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	CIRH1A-11253H	Recombinant Human CIRH1A, GST-tagged	E.coli	GST	C-term-350a.a.	$319 / 25ug
Human	CIRH1A-1376H	Recombinant Human CIRH1A Protein, GST-tagged	Wheat Germ	GST		Inquiry
Human	CIRH1A-1854HF	Recombinant Full Length Human CIRH1A Protein, GST-tagged	In Vitro Cell Free System	GST	686 amino acids	Inquiry
Mouse	CIRH1A-3480M	Recombinant Mouse CIRH1A Protein	Mammalian Cell	His		Inquiry
Mouse	CIRH1A-1696M	Recombinant Mouse CIRH1A Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Mouse	CIRH1A-1696M-B	Recombinant Mouse CIRH1A Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Zebrafish	CIRH1A-12475Z	Recombinant Zebrafish CIRH1A	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein
CIRH1A Related Articles

CIRH1A involved in several pathways and played different roles in them. We selected most pathways CIRH1A participated on our site, such as Ribosome biogenesis in eukaryotes, which may be useful for your reference. Also, other proteins which involved in the same pathway with CIRH1A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Ribosome biogenesis in eukaryotes	NOP10;RRP7A;DKC1;cka1;NOB1;NHP2L1;NMD3;HEATR1;NXF3

CIRH1A has several biochemical functions, for example, poly(A) RNA binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CIRH1A itself. We selected most functions CIRH1A had, and list some proteins which have the same functions with CIRH1A. You can find most of the proteins on our site.

Function	Related Protein
poly(A) RNA binding	S100A4;CDK13;TSNAX;HLTF;REXO4;SNRPG;RPL11;ZFP579;YWHAZ
protein binding	SMC3;NR3C1;MAP2K3;ADRB3;KIR2DL1;TNPO1;MTAP;MBL2;EXD1

CIRH1A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CIRH1A here. Most of them are supplied by our site. Hope this information will be useful for your research of CIRH1A.

HIVEP1; PRNP; uxaA; pgl; NOP56; VPS26A; AK1; FOS; KIF22; IFI16; CERK; HDAC11; Nrip3; HDAC6

Wada, K; Sato, M; et al. Dynamics of WD-repeat containing proteins in SSU processome components. BIOCHEMISTRY AND CELL BIOLOGY-BIOCHIMIE ET BIOLOGIE CELLULAIRE 92:191-199(2014).

Sato, M; Araki, N; et al. Interaction, mobility, and phosphorylation of human orthologues of WD repeat-containing components of the yeast SSU processome t-UTP sub-complex. BIOCHEMISTRY AND CELL BIOLOGY-BIOCHIMIE ET BIOLOGIE CELLULAIRE 91:466-475(2013).