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CKAP5

  • Official Full Name

    cytoskeleton associated protein 5

  • Overview

    This gene encodes a cytoskeleton-associated protein which belongs to the TOG/XMAP215 family. The N-terminal half of this protein contains a microtubule-binding domain and the C-terminal half contains a KXGS motif for binding tubulin dimers. This protein has two distinct roles in spindle formation; it protects kinetochore microtubules from depolymerization and plays an essential role in centrosomal microtubule assembly. This protein may be necessary for the proper interaction of microtubules with the cell cortex for directional cell movement. It also plays a role in translation of the myelin basic protein (MBP) mRNA by interacting with heterogeneous nuclear ribonucleoprotein (hnRNP) A2, which associates with MBP. Alternatively spliced transcript variants encoding different isoforms have been identified.
  • Synonyms

    CKAP5; cytoskeleton associated protein 5; cytoskeleton-associated protein 5; ch TOG; KIAA0097; TOG; TOGp; colonic and hepatic tumor overexpressed gene protein; colonic and hepatic tumor over-expressed gene protein; MSPS; CHTOG; ch-TOG; FLJ35359;

  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Zebrafish
  • E.coli
  • HEK293
  • Mammalian Cell
  • GST
  • His
  • His (Fc)
  • Avi
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human CKAP5-301363H Recombinant Human CKAP5 protein, GST-tagged E.coli GST Met1-Val349
Human CKAP5-791H Recombinant Human CKAP5 Protein, His-tagged E.coli N-His Met1-Ala198
Mouse CKAP5-3493M Recombinant Mouse CKAP5 Protein Mammalian Cell His
Mouse CKAP5-1706M-B Recombinant Mouse CKAP5 Protein Pre-coupled Magnetic Beads HEK293
Mouse CKAP5-1706M Recombinant Mouse CKAP5 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Zebrafish CKAP5-3565Z Recombinant Zebrafish CKAP5 Mammalian Cell His
Chicken CKAP5-4439C Recombinant Chicken CKAP5 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • CKAP5 Related Articles

CKAP5 involved in several pathways and played different roles in them. We selected most pathways CKAP5 participated on our site, such as Anchoring of the basal body to the plasma membrane, Assembly of the primary cilium, Cell Cycle, which may be useful for your reference. Also, other proteins which involved in the same pathway with CKAP5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Anchoring of the basal body to the plasma membraneNINL;TCTN3;TUBB4B;TSGA14;RPGRIP1L;CSNK1E;DCTN1A;DCTN3;MARK4
Assembly of the primary ciliumTCP1;DYNC1H1;ODF2;ATAT1;CSNK1D;TCTEX1D1;CEP97;CCDC123;EXOC5
Cell CycleCDKN2D;GOLGA2;CDKN2A;CDK5RAP2;LIN9;GORASP2;NINL;KIF2C;GINS2
Cell Cycle, MitoticE2F3;KIF18A;KIF2A;NSL1;CCDC99;SPC24;CEP152;ZW10;TUBB4B
Centrosome maturationDCTN2;CLASP1;CEP164;FGFR1OP;TUBB4A;DYNC1I2;CEP290;CDK11A;MAPRE1B
G2/M TransitionDCTN2;ODF2;LIN37;MAPRE1;MAPRE1A;NDE1;CDK11A;CKAP5;DYNC1I2
Loss of Nlp from mitotic centrosomesOFD1;SSNA1;CEP152;MAPRE1B;NEDD1;CP110;CEP135;DCTN1A;PCM1
Loss of proteins required for interphase microtubule organizationfrom the centrosomeODF2B;MAPRE1A;DCTN1A;CEP76;NEDD1;TSGA14;TUBG1;MAPRE1B;CEP57

CKAP5 has several biochemical functions, for example, microtubule binding, ribonucleoprotein complex binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CKAP5 itself. We selected most functions CKAP5 had, and list some proteins which have the same functions with CKAP5. You can find most of the proteins on our site.

Function Related Protein
microtubule bindingCHP1;MAPRE3B;CLIP1;DPYSL2B;KIF5C;VPS41;TERF1;WDR43;PAFAH1B1B
ribonucleoprotein complex bindingPRPF31;SRP54;PRMT5;PIGC;PRPF6;UHMK1;PES1;PITX2;TIMM50

CKAP5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CKAP5 here. Most of them are supplied by our site. Hope this information will be useful for your research of CKAP5.

TACC3; b2rcx0_human; q8iw51; APC; CKAP5; DYNC1H1; CCHCR1; RBPMS; ACADM; SLAIN2; TACC2; ERLIN1; HSPD1; PC; KRT5; ATP5A1; LONP1; ETFB; MTOR

Morielli, T; O'Flaherty, C; et al. Oxidative stress impairs function and increases redox protein modifications in human spermatozoa. REPRODUCTION 149:113-123(2015).
de Leon, CTG; Martin, RDD; et al. Proteomic characterization of the subpellicular cytoskeleton of Toxoplasma gondii tachyzoites. JOURNAL OF PROTEOMICS 111:86-99(2014).
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