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CLCA1

  • Official Full Name

    chloride channel accessory 1

  • Overview

    This gene encodes a member of the calcium sensitive chloride conductance protein family. To date, all members of this gene family map to the same region on chromosome 1p31-p22 and share a high degree of homology in size, sequence, and predicted structure, but differ significantly in their tissue distributions. The encoded protein is expressed as a precursor protein that is processed into two cell-surface-associated subunits, although the site at which the precursor is cleaved has not been precisely determined. The encoded protein may be involved in mediating calcium-activated chloride conductance in the intestine.
  • Synonyms

    CLCA1; chloride channel accessory 1; chloride channel regulator 1 , chloride channel, calcium activated, family member 1; calcium-activated chloride channel regulator 1; CaCC; CLCRG1; CaCC-1; Calcium activated chloride channel 1; Calcium dependent chloride channel 1; Calcium-activated chloride channel family member 1; Calcium-activated chloride channel protein 1; Chloride channel calcium activated family member 1; CLCA1_HUMAN; hCaCC-1; hCLCA1; OTTHUMP00000011907; chloride channel regulator 1; calcium-dependent chloride channel-1; CLCA family member 1, chloride channel regulator; calcium-activated chloride ch; GOB5; CACC1;

  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Pig
  • Rhesus Macaque
  • E. coli
  • E.coli
  • HEK293
  • Mammalian Cell
  • Wheat Germ
  • C
  • His
  • GST
  • His (Fc)
  • Avi
  • Myc
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human CLCA1-10H Recombinant Human CLCA1 protein, His-tagged E.coli His
Human CLCA1-27070TH Recombinant Human CLCA1 protein, GST-tagged Wheat Germ GST
Human CLCA1-01H Recombinant Human CLCA1 protein, His-tagged E.coli His
Human CLCA1-11273H Recombinant Human CLCA1, His-tagged E.coli His C-term-200a.a.
Human CLCA1-08H Recombinant Human CLCA1 Protein, His-tagged E.coli His
Human CLCA1-2452H Recombinant Human CLCA1 protein(741-890 aa), C-His-tagged E. coli C-His 741-890 aa
Rhesus Macaque CLCA1-888R Recombinant Rhesus monkey CLCA1 Protein, His-tagged Mammalian Cell His
Rhesus Macaque CLCA1-714R Recombinant Rhesus Macaque CLCA1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque CLCA1-714R-B Recombinant Rhesus Macaque CLCA1 Protein Pre-coupled Magnetic Beads HEK293
Pig CLCA1-4909P Recombinant Pig CLCA1 protein, His&Myc-tagged E.coli His&Myc 46-199aa
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • CLCA1 Related Articles

CLCA1 involved in several pathways and played different roles in them. We selected most pathways CLCA1 participated on our site, such as Alpha6-Beta4 Integrin Signaling Pathway, Ion channel transport, Olfactory transduction, which may be useful for your reference. Also, other proteins which involved in the same pathway with CLCA1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Alpha6-Beta4 Integrin Signaling PathwayYWHAQ;RTKN;SMAD3B;EIF4E;DSP;CLCA1;EIF4EB;DST;CD151L
Ion channel transportATP13A5;ATP1A1A.4;ATP11C;ANO10A;TRPC4B;GSDMA2;CLCN1;CLCN2;TRPC4A
Olfactory transductionOR51D1;OR2J3;OR8B8;OLFR502;PRKACB;OLFR508;OLFR49;CALML5;OR10J1
Pancreatic secretionRHOA;ITPR3;PLA2G1B;PLCB3;CLCA5;ATP2A1;AMY2A;AMY2A4;ATP1A2
Renin secretionCLCA5;GNAQ;GUCY1A3;AGTR1B;PDE1B;GNAI2;REN2;CLCA4;CALM4
Stimuli-sensing channelsCLIC2;CLCNKA;TRPA1B;TRPC4;SCNN1D;CLCN2;TTYH1;TRPM1A;BEST4
Transmembrane transport of small moleculesANO4;ANO10;SLC17A1;SLC5A11;SLC6A20A;ANO10A;ATP2B3A;SLC15A4;ANO7

CLCA1 has several biochemical functions, for example, chloride channel activity, intracellular calcium activated chloride channel activity, metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CLCA1 itself. We selected most functions CLCA1 had, and list some proteins which have the same functions with CLCA1. You can find most of the proteins on our site.

Function Related Protein
chloride channel activityCLIC5A;SLC26A6;CLCA1;GABRB2;CLIC3;TTYH2;SLC26A6L;TTYH3;APOL1
intracellular calcium activated chloride channel activityANO9;TTYH3;CLCA1;ANO4;ANO6;CLCA4;CLCA2;ANO8;ANO7
metal ion bindingCar8;ZNF16;ATP2B1A;TIPARP;CYP2AA4;NR2F1B;DDAH1;ZNF32;PDLIM5B
metallopeptidase activityBMP1A;AGBL1;ADAMTS8;DPEP3;MMP23B;MMP14B;NAALAD2;ADAM15;CNDP2

CLCA1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CLCA1 here. Most of them are supplied by our site. Hope this information will be useful for your research of CLCA1.

CFTR

Song, LQ; Li, Y; et al. Safety and Immunogenicity of a DNA Vaccine Encoding Human Calcium-Activated Chloride Channel 1 (hCLCA1) in Asthmatic Mice. INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY 161:243-251(2013).
Iwashita, H; Fujimoto, K; et al. Increased human Ca2+-activated Cl- channel 1 expression and mucus overproduction in airway epithelia of smokers and chronic obstructive pulmonary disease patients. RESPIRATORY RESEARCH 13:-(2012).
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