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CLCN3

  • Official Full Name

    chloride channel, voltage-sensitive 3

  • Overview

    This gene encodes a member of the voltage-gated chloride channel (ClC) family. The encoded protein is present in all cell types and localized in plasma membranes and in intracellular vesicles. It is a multi-pass membrane protein which contains a ClC domain and two additional C-terminal CBS (cystathionine beta-synthase) domains. The ClC domain catalyzes the selective flow of Cl- ions across cell membranes, and the CBS domain may have a regulatory function. This protein plays a role in both acidification and transmitter loading of GABAergic synaptic vesicles, and in smooth muscle cell activation and neointima formation. This protein is required for lysophosphatidic acid (LPA)-activated Cl- current activity and fibroblast-to-myofibroblast differentiation. The protein activity is regulated by Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) in glioma cells. Multiple alternatively spliced transcript variants encoding different isoforms have been identified.
  • Synonyms

    CLCN3; chloride channel, voltage-sensitive 3; chloride channel 3; H(+)/Cl(-) exchange transporter 3; ClC 3; CLC3; chloride channel protein 3; chloride transporter ClC-3; ClC-3; DKFZp564I0463;

  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Homo sapiens (Human)
  • Human
  • Mouse
  • Rat
  • E. coli
  • E.coli expression system
  • HEK293
  • In vitro E. coli expression system
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human CLCN3-1417H Recombinant Human CLCN3 Protein, GST-tagged Wheat Germ GST
Human CLCN3-0481H Recombinant Human CLCN3 Full Length Transmembrane protein, His-tagged In vitro E. coli expression system His 1-818aa
Human CLCN3-01H Recombinant Human CLCN3 Protein, His-tagged E. coli His
Mouse CLCN3-3514M Recombinant Mouse CLCN3 Protein Mammalian Cell His
Mouse CLCN3-1719M Recombinant Mouse CLCN3 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse CLCN3-1719M-B Recombinant Mouse CLCN3 Protein Pre-coupled Magnetic Beads HEK293
Rat CLCN3-1426R Recombinant Rat CLCN3 Protein Mammalian Cell His
Rat CLCN3-1084R-B Recombinant Rat CLCN3 Protein Pre-coupled Magnetic Beads HEK293
Rat CLCN3-1084R Recombinant Rat CLCN3 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Homo sapiens (Human) RFL30363HF Recombinant Human H(+)/Cl(-) Exchange Transporter 3(Clcn3) Protein, His-Tagged E.coli expression system His Full Length (1-818aa)
  • Involved Pathway
  • Protein Function
  • Interacting Protein

CLCN3 involved in several pathways and played different roles in them. We selected most pathways CLCN3 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with CLCN3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein

CLCN3 has several biochemical functions, for example, ATP binding, PDZ domain binding, antiporter activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CLCN3 itself. We selected most functions CLCN3 had, and list some proteins which have the same functions with CLCN3. You can find most of the proteins on our site.

Function Related Protein
ATP bindingGSK3A;PTK6;KIF4;DCLK1A;ABCC10;ATP2A1;MYO3A;FARS2;PRPS2
PDZ domain bindingDLG1;BAIAP2;ACCN3;SLC9A3R1;MAP2K2;SLC26A6;ACVR2A;LNX2;KIDINS220B
antiporter activitySLC7A6;SLC47A1;SLC35E3;SLC38A3;SLC26A3.2;SLC7A13;SLC9A3.2;SLC35D1A;SLC7A14
chloride channel activityGRAP2;FXYD3;GABRE;CLCNKB;BEST1;SLC26A3;GABRA3;SLC26A4;GABRP
ion channel activityKCNV2B;TRPC7A;FXYD6;CLCN3;GRIN1B;TRPV5;TRPM1;KCNA2B;TRPC2B
nucleotide bindingPTBP1A;MAPKAPK2B;SMYHC3;RBM10;TOR1L3;FHIT;KALRN;RNPS1;RAB11BA
protein heterodimerization activityAPITD1;CLNS1A;HIST1H2BH;SNX2;SNX1;SYCP2;THRA;ADD2;ADORA2A
voltage-gated chloride channel activityCLCN5;CLCN3;CLCN1A;CLCN2;CLCN1;ANO6;CLCN7;CLCNK;CLCN6
voltage-gated ion channel activityKCNC3B;CACNA1BA;CACNG2A;SCN11A;SCN12AA;CLCN3;NALCN;TRPM5;KCNJ1A.3
NOT volume-sensitive chloride channel activity

CLCN3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CLCN3 here. Most of them are supplied by our site. Hope this information will be useful for your research of CLCN3.

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