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CLCN5

Official Full Name

chloride channel 5
Overview

This gene encodes a member of the ClC family of chloride ion channels and ion transporters. Mutations in this gene have been found in Dent disease and renal tubular disorders complicated by nephrolithiasis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Synonyms

CLCN5; chloride channel 5; nephrolithiasis 1 (X linked) , nephrolithiasis 2, X linked , NPHL1, NPHL2; H(+)/Cl(-) exchange transporter 5; ClC 5; CLC5; Dent disease; DENTS; hCIC K2; hClC K2; XLRH; XRN; Chloride channel protein 5; Chloride transporter ClC-5; ClC-5; CLCK2; CLCN5_HUMAN; hCIC-K2; NPHL1; NPHL2; OTTHUMP00000023279; OTTHUMP00000023280; OTTHUMP00000023281; OTTHUMP00000023282; hClC-K2;

Type

Recombinant Proteins
Cell & Tissue Lysates
Protein Pre-coupled Magnetic Beads

Species

Human
Rat

Source

E.coli
HEK293
In Vitro Cell Free System
Mammalian Cell
Wheat Germ

Tag

GST
His
His (Fc)
Avi
N/A

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	CLCN5-1418H	Recombinant Human CLCN5 Protein, GST-tagged	Wheat Germ	GST		Inquiry
Human	CLCN5-7473HCL	Recombinant Human CLCN5 293 Cell Lysate	HEK293	N/A		Inquiry
Human	CLCN5-3998H	Recombinant Human CLCN5 protein, His-tagged	E.coli	His	627-685 aa	$319 / 25ug
Human	CLCN5-1995HF	Recombinant Full Length Human CLCN5 Protein, GST-tagged	In Vitro Cell Free System	GST	746 amino acids	Inquiry
Rat	CLCN5-1427R	Recombinant Rat CLCN5 Protein	Mammalian Cell	His		Inquiry
Rat	CLCN5-1085R-B	Recombinant Rat CLCN5 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Rat	CLCN5-1085R	Recombinant Rat CLCN5 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry

Involved Pathway
Protein Function
Interacting Protein

CLCN5 involved in several pathways and played different roles in them. We selected most pathways CLCN5 participated on our site, such as Ion channel transport, Stimuli-sensing channels, Transmembrane transport of small molecules, which may be useful for your reference. Also, other proteins which involved in the same pathway with CLCN5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Ion channel transport	ASPH;ATP1A1A.3;NHEDC1;ATP8B1;CLCN2;ANO10A;CLCN1;ANO10;GLRBA
Stimuli-sensing channels	ANO4;CLIC2;WNK2;TRPM4C;ANO5B;SLC17A3;CLCN5;TRPC4APA;TRPC4A
Transmembrane transport of small molecules	SLC38A4;ANKHB;SLC4A1A;MATE4;SLC6A1B;SLC43A2A;SLCO2B1;TPCN1;SLC9A7

CLCN5 has several biochemical functions, for example, ATP binding, antiporter activity, chloride channel activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CLCN5 itself. We selected most functions CLCN5 had, and list some proteins which have the same functions with CLCN5. You can find most of the proteins on our site.

Function	Related Protein
ATP binding	DNAJA2;CSNK2A2A;DDX53;PAPSS2B;MAP2K4;ERBB4A;MOV10B.1;DDX31;TNIKB
antiporter activity	SLC9A9;SLC7A3A;CLCN7;CLCN4-2;SLC35E1;SLC7A6;TMEM241;SLC47A1;SLC26A3.2
chloride channel activity	GABRE;GABRA6;GABRR1;CLCN3;SLC26A4;CLCNKB;GABRD;CLIC3;GABRA5
voltage-gated chloride channel activity	CLCNK;ANO6;CLCNKA;CLCN7;CLCN4;CLCN1A;CLCN2;CLCN5;CLCN6

CLCN5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CLCN5 here. Most of them are supplied by our site. Hope this information will be useful for your research of CLCN5.