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CLDN14

Official Full Name

claudin 14
Overview

Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are comprised of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. The protein encoded by this gene, a member of the claudin family, is an integral membrane protein and a component of tight junction strands. The encoded protein also binds specifically to the WW domain of Yes-associated protein. Defects in this gene are the cause of an autosomal recessive form of nonsyndromic sensorineural deafness. It is also reported that four synonymous variants in this gene are associated with kidney stones and reduced bone mineral density. Several transcript variants encoding the same protein have been found for this gene.
Synonyms

CLDN14; claudin 14; DFNB29; claudin-14; MGC109472; AI851731; CLD14_HUMAN; CLDN 14; DFNB 29; Human CLDN14 gene; OTTHUMP00000109046; OTTHUMP00000109049; OTTMUSP00000021531; UNQ777/PRO1571;

Type

Recombinant Proteins
Cell & Tissue Lysates
Protein Pre-coupled Magnetic Beads

Species

Homo sapiens (Human)
Human
Rhesus Macaque

Source

E.coli expression system
HEK293
In Vitro Cell Free System
Mammalian Cell
Wheat Germ

Tag

GST
His
His (Fc)
Avi
N/A

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	CLDN14-1430H	Recombinant Human CLDN14 Protein, GST-tagged	Wheat Germ	GST		Inquiry
Human	CLDN14-7470HCL	Recombinant Human CLDN14 293 Cell Lysate	HEK293	N/A		Inquiry
Human	CLDN14-2041HF	Recombinant Full Length Human CLDN14 Protein, GST-tagged	In Vitro Cell Free System	GST	239 amino acids	Inquiry
Homo sapiens (Human)	RFL21545HF	Recombinant Full Length Human Claudin-14(Cldn14) Protein, His-Tagged	E.coli expression system	His	Full Length (1-239)	Inquiry
Rhesus Macaque	CLDN14-893R	Recombinant Rhesus monkey CLDN14 Protein, His-tagged	Mammalian Cell	His		Inquiry
Rhesus Macaque	CLDN14-719R-B	Recombinant Rhesus Macaque CLDN14 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Rhesus Macaque	CLDN14-719R	Recombinant Rhesus Macaque CLDN14 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry

Involved Pathway
Protein Function
Interacting Protein
CLDN14 Related Articles
CLDN14 Related Research Area

CLDN14 involved in several pathways and played different roles in them. We selected most pathways CLDN14 participated on our site, such as Cell adhesion molecules (CAMs), Tight junction, Leukocyte transendothelial migration, which may be useful for your reference. Also, other proteins which involved in the same pathway with CLDN14 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Cell adhesion molecules (CAMs)	ITGAM;NLGN3;CLDN7A;ITGB8;CD34;CLDN15A;PTPRF;HLA-C;CLDN20
Tight junction	MYHZ2;HRASB;MYL10;PPP2R2D;PPP2R1B;INADL;MYH1;TJP2A;NRAS
Leukocyte transendothelial migration	MAPK13;RHOA;PIK3CD;VAV2;MYL10;ACTG1;CXCL12;PXN;CLDN2
Hepatitis C	RNASEL;GSK3B;OAS2;CLDN20;CXCL8;EIF2AK1;SOS1;PIK3R1;IFNA17

CLDN14 has several biochemical functions, for example, identical protein binding, structural molecule activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CLDN14 itself. We selected most functions CLDN14 had, and list some proteins which have the same functions with CLDN14. You can find most of the proteins on our site.

Function	Related Protein
identical protein binding	CLDN9;BAG2;Serpina1b;MTSS1;ALDH4A1;SYT9;SNCA;RAD52;TTC32
structural molecule activity	NEFH;CDC42SE1;KRTAP11-1;LCE1B;ANXA1;ANK1;NEFMB;CLDN11;FGA

CLDN14 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CLDN14 here. Most of them are supplied by our site. Hope this information will be useful for your research of CLDN14.

Agaimy, A; Buslei, R; et al. Comparative study of soft tissue perineurioma and meningioma using a five-marker immunohistochemical panel. HISTOPATHOLOGY 65:60-70(2014).

Jo, VY; Cibas, ES; et al. Claudin-4 immunohistochemistry is highly effective in distinguishing adenocarcinoma from malignant mesothelioma in effusion cytology. CANCER CYTOPATHOLOGY 122:299-306(2014).

Claudins