CLDN19
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Official Full Name
claudin 19
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Overview
The product of this gene belongs to the claudin family. It plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity. Defects in this gene are the cause of hypomagnesemia renal with ocular involvement (HOMGO). HOMGO is a progressive renal disease characterized by primary renal magnesium wasting with hypomagnesemia, hypercalciuria and nephrocalcinosis associated with severe ocular abnormalities such as bilateral chorioretinal scars, macular colobomata, significant myopia and nystagmus. Alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. -
Synonyms
CLDN19; claudin 19; claudin-19; CLDN 19; HOMG5;
- Recombinant Proteins
- Protein Pre-coupled Magnetic Beads
- Homo sapiens (Human)
- Human
- Mouse
- Mus musculus (Mouse)
- Rat
- Rattus norvegicus (Rat)
- Zebrafish
- E.coli expression system
- HEK293
- HEK293T
- In Vitro Cell Free System
- Mammalian Cell
- Wheat Germ
- GST
- His
- His (Fc)
- Avi
- Myc
- DDK
- Myc|DDK
- Involved Pathway
- Protein Function
- Interacting Protein
- CLDN19 Related Research Area
CLDN19 involved in several pathways and played different roles in them. We selected most pathways CLDN19 participated on our site, such as Cell adhesion molecules (CAMs), Tight junction, which may be useful for your reference. Also, other proteins which involved in the same pathway with CLDN19 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Cell adhesion molecules (CAMs) | OCLNA;NLGN4A;MPZ;SELPLG;Itgam&Itgb2;ICAM3;L1CAM;CD6;SDC2 |
| Tight junction | TJP2A;RAB3B;OCLNB;VMHC;EPB41L3;CLDN20;MYL9A;CLDN9;EPB41L3B |
CLDN19 has several biochemical functions, for example, structural molecule activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CLDN19 itself. We selected most functions CLDN19 had, and list some proteins which have the same functions with CLDN19. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| structural molecule activity | COPB1;JAG1;SPRR3;COL4A3;KRT28;COL15A1;CTNNA1;TUBGCP3;EPB41L3A |
CLDN19 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CLDN19 here. Most of them are supplied by our site. Hope this information will be useful for your research of CLDN19.
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