CLDN4
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Official Full Name
claudin 4
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Overview
This gene encodes an integral membrane protein, which belongs to the claudin family. The protein is a component of tight junction strands and may play a role in internal organ development and function during pre- and postnatal life. This gene is deleted in Williams-Beuren syndrome, a neurodevelopmental disorder affecting multiple systems. -
Synonyms
CLDN4; claudin 4; CPETR, CPETR1; claudin-4; Clostridium perfringens enterotoxin receptor 1; CPE R; hCPE R; WBSCR8; Williams Beuren syndrome chromosomal region 8 protein; CPE-receptor; Williams-Beuren syndrome chromosomal region 8 protein; CPER; CPE-R; CPE;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Bos taurus (Bovine)
- Chlorocebus aethiops (Green monkey) (Cercopithecus aethiops)
- Homo sapiens (Human)
- Human
- Mouse
- Mus musculus (Mouse)
- Rhesus Macaque
- Baculovirus-Insect cells
- E.coli expression system
- HEK293
- HEK293T
- In Vitro Cell Free System
- Insect Cell
- Mammalian Cell
- Mammalian cells
- Wheat Germ
- C
- His
- Flag
- GST
- His (Fc)
- Avi
- Twin
- Strep
- Myc
- DDK
- MYC
- N/A
- Involved Pathway
- Protein Function
- Interacting Protein
- CLDN4 Related Articles
- CLDN4 Related Research Area
CLDN4 involved in several pathways and played different roles in them. We selected most pathways CLDN4 participated on our site, such as Cell adhesion molecules (CAMs), Cell junction organization, Cell-Cell communication, which may be useful for your reference. Also, other proteins which involved in the same pathway with CLDN4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Cell adhesion molecules (CAMs) | CLDN5A;CLDNC;CLDNA;Ntng2;SELPLG;CNTN1A;HLA-C;BMA1;CDH1 |
| Cell junction organization | COL17A1A;CDH6;PVRL2L;F11R.2;CADM2B;CLDN20;CLDN3;CLDN7;PLECA |
| Cell-Cell communication | PLECA;SPTBN1;CADM2A;DCC;CDH4;CDH12A;CDH10;CDH5;CDH8 |
| Cell-cell junction organization | CTNND1;CDH9;CDH24;CDH8;INADL;CDH18;CLDN7;CDH5;CLDN16 |
| Hepatitis C | NFKBIA;PPP2R1B;EIF2AK1;OSTN;PIK3R5;AKT2;ARAF;IFNA5;MAPK8 |
| Leukocyte transendothelial migration | ITGB1;ITGA4;PRKCB;GNAI2;MYL12B;CLDN1;NCF2;MSN;MYL7 |
| Tight junction | PPP2R2D;CLDN15A;MYH10;SHROOM3;PARD3;ACTN4;AKT2L;CLDN8;JAM3 |
| Tight junction interactions | CLDN20;CLDN3;INADL;CLDN4;CLDN23;CLDN7;CLDN16 |
CLDN4 has several biochemical functions, for example, identical protein binding, structural molecule activity, transmembrane signaling receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CLDN4 itself. We selected most functions CLDN4 had, and list some proteins which have the same functions with CLDN4. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| identical protein binding | NCL;FRS3;BLOC1S6;IGF2R;MCM6;PFKM;ZHX2;LRRK1;SDF4 |
| structural molecule activity | KRT93;KRT72-PS;ADD1;IFLTD1;SNTA1;KRT19;CLDN5A;SEMG1;CLDN19 |
| transmembrane signaling receptor activity | GPR133;SEMA4D;KIR2DS2;SORL1;OR115-6;FZD9B;LILRB5;LEPR;LGR4 |
CLDN4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CLDN4 here. Most of them are supplied by our site. Hope this information will be useful for your research of CLDN4.
TACSTD2
- Q&As
- Reviews
Q&As (5)
Ask a questionInhibiting CLDN4 function could enhance the efficacy of existing cancer therapies and potentially lead to the development of new treatment strategies.
CLDN4 is involved in regulating the entry of certain pathogens into host cells, making it a potential target for the development of antiviral and antibacterial therapies.
Research is underway to explore the potential of targeting CLDN4 to modulate tissue barrier function and alleviate the symptoms of autoimmune diseases.
Monitoring CLDN4 levels and function may provide valuable insights into the progression of IBD and help in the development of targeted therapies.
CLDN4 is also being studied in the context of kidney disease, skin disorders, and neurodegenerative diseases due to its role in maintaining tissue barrier function.
Customer Reviews (3)
Write a reviewThe CLDN4 protein showcases outstanding quality, ensuring its suitability for addressing my experimental requirements effectively.
the manufacturer's dedication to excellent technical support assures me that any challenges or obstacles I encounter will be swiftly resolved.
Its top-notch purity and integrity instill confidence in obtaining precise and reliable data, thereby enabling significant advancements in my research.
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