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CLIP3

Official Full Name

CAP-GLY domain containing linker protein 3
Overview

This gene encodes a member of the cytoplasmic linker protein 170 family. Members of this protein family contain a cytoskeleton-associated protein glycine-rich domain and mediate the interaction of microtubules with cellular organelles. The encoded protein plays a role in T cell apoptosis by facilitating the association of tubulin and the lipid raft ganglioside GD3. The encoded protein also functions as a scaffold protein mediating membrane localization of phosphorylated protein kinase B. Alternatively spliced transcript variants have been observed for this gene.
Synonyms

CLIP3; CAP-GLY domain containing linker protein 3; CAP-Gly domain-containing linker protein 3; CLIP 170 related; CLIPR 59; restin like 1; RSNL1; CAP GLY domain containing linker protein 3; CLIP 170 related 59 kDa protein; CLIP-170-related 59 kDa protein; CLIP3_HUMAN; CLIPR-59; CLIPR59; Cytoplasmic linker protein 170 related 59 kDa protein; Cytoplasmic linker protein 170-related 59 kDa protein; restin-like 1;

Type

Recombinant Proteins
Cell & Tissue Lysates
Protein Pre-coupled Magnetic Beads

Species

Human
Mouse
Rhesus Macaque

Source

E.coli
HEK293
Mammalian Cell
Wheat Germ

Tag

GST
GST|His
His
His (Fc)
Avi
N/A

Species	Cat.#	Product name	Source (Host)	Tag	Price
Human	CLIP3-1489H	Recombinant Human CLIP3 Protein, GST-tagged	Wheat Germ	GST	Inquiry
Human	CLIP3-7443HCL	Recombinant Human CLIP3 293 Cell Lysate	HEK293	N/A	Inquiry
Human	CLIP3-3258H	Recombinant Human CLIP3 Protein, GST/His-tagged	E.coli	GST/His	Inquiry
Mouse	CLIP3-3584M	Recombinant Mouse CLIP3 Protein	Mammalian Cell	His	Inquiry
Mouse	CLIP3-1758M-B	Recombinant Mouse CLIP3 Protein Pre-coupled Magnetic Beads	HEK293		Inquiry
Mouse	CLIP3-1758M	Recombinant Mouse CLIP3 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi	Inquiry
Rhesus Macaque	CLIP3-911R	Recombinant Rhesus monkey CLIP3 Protein, His-tagged	Mammalian Cell	His	Inquiry
Rhesus Macaque	CLIP3-736R-B	Recombinant Rhesus Macaque CLIP3 Protein Pre-coupled Magnetic Beads	HEK293		Inquiry
Rhesus Macaque	CLIP3-736R	Recombinant Rhesus Macaque CLIP3 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi	Inquiry

Involved Pathway
Protein Function
Interacting Protein
CLIP3 Related Articles

CLIP3 involved in several pathways and played different roles in them. We selected most pathways CLIP3 participated on our site, such as Death Receptor Signalling, Regulation of TNFR1 signaling, Signal Transduction, which may be useful for your reference. Also, other proteins which involved in the same pathway with CLIP3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Death Receptor Signalling	USP2;SHRPRBCK1R;TAX1BP1;OTULIN;OTULINB;CLIP3;SHARPIN;TAB1;OTUD7B
Regulation of TNFR1 signaling	OTUD7B;USP2;CLIP3;TAX1BP1B;FAM105B;TAX1BP1;USP4;SHRPRBCK1R;OTULIN
Signal Transduction	DNAL4;PRICKLE1B;NTS;MYO9B;ABI1A;DHRS4;AXL;RNF31;UTS2
TNF signaling	OTULIN;SHARPIN;TAX1BP1;TAX1BP1B;USP2;RNF31;SHRPRBCK1R;CLIP3;USP4

CLIP3 has several biochemical functions, for example, ganglioside binding, microtubule binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CLIP3 itself. We selected most functions CLIP3 had, and list some proteins which have the same functions with CLIP3. You can find most of the proteins on our site.

Function	Related Protein
ganglioside binding
microtubule binding	KIF19;MAPRE1B;KATNAL2;KIF25;MAP1S;PAFAH1B1B;KIF5AA;MAPRE3A;CASC1

CLIP3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CLIP3 here. Most of them are supplied by our site. Hope this information will be useful for your research of CLIP3.

Ciecholewski, M; et al. Ischemic heart disease detection using selected machine learning methods. INTERNATIONAL JOURNAL OF COMPUTER MATHEMATICS 90:1734-1759(2013).

Couesnon, A; Offner, N; et al. CLIPR-59: a protein essential for neuromuscular junction stability during mouse late embryonic development. DEVELOPMENT 140:1583-1593(2013).