Clu
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Official Full Name
clusterin
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Overview
The protein encoded by this gene is a secreted chaperone that can under some stress conditions also be found in the cell cytosol. It has been suggested to be involved in several basic biological events such as cell death, tumor progression, and neurodegenerative disorders. Alternate splicing results in both coding and non-coding variants.[provided by RefSeq, May 2011] -
Synonyms
CLU; clusterin; CLI; AAG4; APOJ; CLU1; CLU2; KUB1; SGP2; APO-J; SGP-2; SP-40; TRPM2; TRPM-2; NA1/NA2; apolipoprotein J; ku70-binding protein 1; sulfated glycoprotein 2; aging-associated protein 4; complement lysis inhibitor; complement cytolysis inhibitor; complement-associated protein SP-40,40; testosterone-repressed prostate message 2;
- Recombinant Proteins
- Diagnostic Enzyme
- Cell & Tissue Lysates
- Native Proteins
- Antibody
- Protein Pre-coupled Magnetic Beads
- Canine
- Cattle
- Chicken
- Chinese hamster
- Dog
- Human
- Mouse
- Pig
- Rabbit
- Rat
- Rhesus Macaque
- Zebrafish
- CHO Cells
- E.coli
- HEK293
- HEK293T
- Human Cell
- Human plasma
- Human Plasma
- Mammalian Cell
- Mammalian cells
- Mouse
- Plasma
- Wheat Germ
- C
- Fc
- His
- Flag
- Fc|His
- FLAG
- GST
- His (Fc)
- Avi
- His|S
- His|T7
- SUMO
- Myc
- DDK
- MYC
- Myc|DDK
- N/A
- N
- 6×His
- T7|His
- Involved Pathway
- Protein Function
- Interacting Protein
- Clu Related Articles
- Clu Related Research Area
Clu involved in several pathways and played different roles in them. We selected most pathways Clu participated on our site, such as Hemostasis, Platelet activation, signaling and aggregation, Platelet degranulation, which may be useful for your reference. Also, other proteins which involved in the same pathway with Clu were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Hemostasis | SLC7A10;DOCK7;KIF2A;IRF1B;KIF22;GATA2A;SLC7A6;NADL1.1;KCNMA1 |
| Platelet activation, signaling and aggregation | CD9A;CLEC1B;G6b;SRGN;WDR1;STXBP3;STXBP3A;TRPC6A;GNA13B |
| Platelet degranulation | CAP1;IGF2B;CALU;TFA;HRG;AASS;WDR1;PLEK;BRPF3 |
| Response to elevated platelet cytosolic Ca2+ | TFA;MMRN1;STXBP3A;SRGN;MMRN2A;PLEK;STXBP3;CD9B;CLU |
| Validated targets of C-MYC transcriptional repression | TMEFF2;SFXN3;GFI1;LGALS1;CSDE1;NDRG1;CLU;ZFP36L1;TMEM126A |
Clu has several biochemical functions, for example, NOT ATPase activity, chaperone binding, misfolded protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Clu itself. We selected most functions Clu had, and list some proteins which have the same functions with Clu. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| NOT ATPase activity | MYO18A;KIF26A;RUVBL1;CLU |
| chaperone binding | DNAJB1;ATP1A1;BIRC5;HES1;PFDN6;DNAJA2L;DNAJA2;HSP104;AHSA1L |
| misfolded protein binding | SDF2L1;F12;BAG6;TOR1A;HDAC6;HSPD1;STUB1;CLU;HSPA5 |
| protein binding | SLC3A2;SH3GL1;CHCHD3;PGM1;ASIC1;PIDD1;CTAG1B;CKB;FAM19A1 |
| ubiquitin protein ligase binding | POLR2A;H2-AB1;CUL1B;LRPPRC;PRR5L;GABARAPL2;VCL;LYN;PINK1 |
Clu has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Clu here. Most of them are supplied by our site. Hope this information will be useful for your research of Clu.
PDIA3; ADCYAP1; FOS; PPARG; Stag2; NR3C1; ZNF24; NR4A1; MDM2; BCL2L1; KLF11; POLR1C; CYP2E1
- Q&As
- Reviews
Q&As (5)
Ask a questionCLU has anti-inflammatory properties and modulates immune responses. Its involvement in autoimmunity is linked to its ability to regulate immune cell functions and cytokine production.
CLU plays a role in regulating cell survival and apoptosis by interacting with key cellular components, including Bcl-2 family members and caspases, modulating apoptotic pathways.
CLU modulates cell adhesion and migration, contributing to tissue remodeling and repair. Its interactions with extracellular matrix components influence cellular behaviors in wound healing and tissue homeostasis.
CLU is implicated in neurodegenerative disorders, particularly Alzheimer's disease. Its involvement in processes such as amyloid-beta aggregation and clearance influences disease progression.
CLU interacts with lipids, participating in lipid transport and metabolism. Its role in lipoprotein remodeling and cholesterol homeostasis links it to cardiovascular health.
Customer Reviews (3)
Write a reviewImpressed with the quality control. This product is a gem in our lab experiments.
Smooth transactions and swift delivery. Our lab supplies are incomplete without this protein.
Our lab manager introduced us to this product, and we're never going back. Essential for our studies.
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