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CNOT2

  • Official Full Name

    CCR4-NOT transcription complex, subunit 2

  • Overview

    This gene encodes a subunit of the multi-component CCR4-NOT complex. The CCR4-NOT complex regulates mRNA synthesis and degradation and is also thought to be involved in mRNA splicing, transport and localization. The encoded protein interacts with histone deacetylases and functions as a repressor of polymerase II transcription. Alternatively spliced transcript variants have been observed for this gene.
  • Synonyms

    CNOT2; CCR4-NOT transcription complex, subunit 2; NOT2; CCR4-NOT transcription complex subunit 2; CDC36; NOT2H; CCR4 associated factor 2; CCR4 NOT transcription complex subunit 2; CCR4-associated factor 2; HSPC131; MSTP046; NOT2 (negative regulator of transcription 2 yeast) homolog; OTTHUMP00000241224; OTTHUMP00000241234; OTTHUMP00000241236; negative regulator of transcription 2;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Rhesus Macaque
  • Zebrafish
  • E.coli
  • HEK293
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human CNOT2-190H Recombinant Human CNOT2 Protein, His-tagged E.coli His
Human CNOT2-1578H Recombinant Human CNOT2 Protein, GST-tagged Wheat Germ GST
Human CNOT2-7403HCL Recombinant Human CNOT2 293 Cell Lysate HEK293 N/A
Human CNOT2-1936HF Recombinant Full Length Human CNOT2 Protein, GST-tagged In Vitro Cell Free System GST 540 amino acids
Human CNOT2-2465H Recombinant Human CNOT2 protein, His-tagged E.coli His 336-540 aa
Mouse CNOT2-3665M Recombinant Mouse CNOT2 Protein Mammalian Cell His
Mouse CNOT2-1813M Recombinant Mouse CNOT2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse CNOT2-1813M-B Recombinant Mouse CNOT2 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque CNOT2-938R Recombinant Rhesus monkey CNOT2 Protein, His-tagged Mammalian Cell His
Rhesus Macaque CNOT2-763R Recombinant Rhesus Macaque CNOT2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque CNOT2-763R-B Recombinant Rhesus Macaque CNOT2 Protein Pre-coupled Magnetic Beads HEK293
Zebrafish CNOT2-5613Z Recombinant Zebrafish CNOT2 Mammalian Cell His
Chicken CNOT2-2036C Recombinant Chicken CNOT2 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • CNOT2 Related Articles

CNOT2 involved in several pathways and played different roles in them. We selected most pathways CNOT2 participated on our site, such as RNA degradation, which may be useful for your reference. Also, other proteins which involved in the same pathway with CNOT2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
RNA degradationPABPC3;CNOT1;MPHOSPH6;ENO2;PABPC1A;ENO3;CNOT6;PFKL;DDX6

CNOT2 has several biochemical functions, for example, RNA polymerase II transcription cofactor activity, RNA polymerase II transcription corepressor binding, contributes_to poly(A)-specific ribonuclease activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CNOT2 itself. We selected most functions CNOT2 had, and list some proteins which have the same functions with CNOT2. You can find most of the proteins on our site.

Function Related Protein
RNA polymerase II transcription cofactor activityRBM14;PPARGC1A;MED13A;MED19A;THRAP3;NKX2;MED11;MED14;MED30
RNA polymerase II transcription corepressor binding
contributes_to poly(A)-specific ribonuclease activityCNOT2;PAN3;CNOT1
protein bindingPPP6R2;C6orf211;IPO13;SGOL2;MATR3;HHIP;STRADB;ZMYND11;C4BPB

CNOT2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CNOT2 here. Most of them are supplied by our site. Hope this information will be useful for your research of CNOT2.

CNOT1; CNOT3; CNOT6L; CNOT8; TNRC6C; Cnot7; HDAC3; SS18

Turowski, TW; et al. The impact of transcription on posttranscriptional processes in yeast. GENE 526:23-29(2013).
Collart, MA; Panasenko, OO; et al. The Not3/5 subunit of the Ccr4-Not complex: A central regulator of gene expression that integrates signals between the cytoplasm and the nucleus in eukaryotic cells. CELLULAR SIGNALLING 25:743-751(2013).
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