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CNR2

  • Official Full Name

    cannabinoid receptor 2 (macrophage)

  • Overview

    The cannabinoid delta-9-tetrahydrocannabinol is the principal psychoactive ingredient of marijuana. The proteins encoded by this gene and the cannabinoid receptor 1 (brain) (CNR1) gene have the characteristics of a guanine nucleotide-binding protein (G-protein)-coupled receptor for cannabinoids. They inhibit adenylate cyclase activity in a dose-dependent, stereoselective, and pertussis toxin-sensitive manner. These proteins have been found to be involved in the cannabinoid-induced CNS effects (including alterations in mood and cognition) experienced by users of marijuana. The cannabinoid receptors are members of family 1 of the G-protein-coupled receptors. [provided by RefSeq, Jul 2008]
  • Synonyms

    CNR2; cannabinoid receptor 2 (macrophage); CB2; CX5; CB-2; cannabinoid receptor 2; testis-dominant CNR2 isoform CB2;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Assay Kits
  • Homo sapiens (Human)
  • Human
  • Mouse
  • Mus musculus (Mouse)
  • Rat
  • Rattus norvegicus (Rat)
  • Zea mays (Maize)
  • Zebrafish
  • E.coli
  • E.coli expression system
  • HEK293
  • In Vitro Cell Free System
  • In vitro E. coli expression system
  • Mammalian Cell
  • Wheat Germ
  • His
  • His (Fc)
  • Avi
  • Flag
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human CNR2-26236TH Recombinant Human CNR2 Wheat Germ N/A 360 amino acids
Human CNR2-738H Recombinant Human CNR2 protein(Met1-Cys360) HEK293 N/A Met1-Cys360
Human CNR2-7394HCL Recombinant Human CNR2 293 Cell Lysate HEK293 N/A
Human CNR2-1154HFL Recombinant Human CNR2 protein, His&Flag-tagged HEK293 His&Flag 1-360 aa
Human CNR2-2703H-B Recombinant Human CNR2 Protein Pre-coupled Magnetic Beads HEK293
Human CNR2-29H Recombinant Human CNR2 Full Length Transmembrane protein, His-tagged In vitro E. coli expression system His 1-360aa
Human CNR2-102HF Recombinant Full Length Human CNR2 Protein In Vitro Cell Free System 360 amino acids
Human CNR2-2703H Recombinant Human CNR2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse CNR2-3678M Recombinant Mouse CNR2 Protein Mammalian Cell His
Mouse CNR2-1823M Recombinant Mouse CNR2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse CNR2-1823M-B Recombinant Mouse CNR2 Protein Pre-coupled Magnetic Beads HEK293
Rat Cnr2-29R Recombinant Rat Cnr2 Protein, His-tagged E.coli His Met1~Asn104
Homo sapiens (Human) RFL26956HF Recombinant Full Length Human Cannabinoid Receptor 2(Cnr2) Protein, His-Tagged E.coli expression system His Full Length (1-360aa)
Mus musculus (Mouse) RFL32311MF Recombinant Full Length Mouse Cannabinoid Receptor 2(Cnr2) Protein, His-Tagged E.coli expression system His Full Length (1-347)
Rattus norvegicus (Rat) RFL18885RF Recombinant Full Length Rat Cannabinoid Receptor 2(Cnr2) Protein, His-Tagged E.coli expression system His Full Length (1-360)
Zea mays (Maize) RFL25273ZF Recombinant Full Length Zea Mays Cell Number Regulator 2(Cnr2) Protein, His-Tagged E.coli expression system His Full Length (1-181)
Zebrafish CNR2-12213Z Recombinant Zebrafish CNR2 Mammalian Cell His
Kit-1045 Phagocytosis Assay Kit (Red Zymosan) N/A
Kit-1181 cAMP CNR2 (CB2) CHO-K1 GPCR Assay Kit N/A
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • CNR2 Related Articles
  • CNR2 Related Research Area

CNR2 involved in several pathways and played different roles in them. We selected most pathways CNR2 participated on our site, such as Class A/1 (Rhodopsin-like receptors), G alpha (i) signalling events, GPCR downstream signaling, which may be useful for your reference. Also, other proteins which involved in the same pathway with CNR2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Class A/1 (Rhodopsin-like receptors)NPB;EDN2;DRD5;CXCL11.8;EDNRAB;CHRM4;CCR7;KEL;OXTRL
G alpha (i) signalling eventsOPN1MW;RGS6;SST;CCR9;ANXA1B;SSTR1;DRD2;GPR55A;RGR
GPCR downstream signalingRLN2;TAAR1;S1PR5B;CCL19A.2;NMBA;NPFF;CNR1;RLN3;GPBAR1
GPCR ligand bindingFPR-RS4;AGT;SSTR5;TAAR1;INSL3;CYSLTR1;HCRT;PENKB;RAMP3
GPCRs, Class A Rhodopsin-likeSSTR5;ACKR4;OPN1MW;CYSLTR1;ADORA3;CCBP2;DRD3;FPR-RS4;GPR75
Neuroactive ligand-receptor interactionP2RX7;P2RY14;F2RL2;ADRB3B;CHRNA2;MC5RB;MTNR1B;KISS1R;PRLR
Signal TransductionZFPM2B;CNR2;RHOF;ARHGAP12B;APOA4A;CIT;ANXA1B;ARHGAP17B;ARHGAP25
Signaling by GPCRPROKR1A;OR2AP1;GPR39;ARHGEF1B;RGS20;TAS2R3;MLN;OXTRL;DCLRE1B

CNR2 has several biochemical functions, for example, cannabinoid receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CNR2 itself. We selected most functions CNR2 had, and list some proteins which have the same functions with CNR2. You can find most of the proteins on our site.

Function Related Protein
cannabinoid receptor activityCNR1;GPR55;CNR2

CNR2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CNR2 here. Most of them are supplied by our site. Hope this information will be useful for your research of CNR2.

win 55212-2; PSMD2; q81pt2_bacan; mtaD

Simkins, T; Crawford, RB; et al. Enhanced Humoral Immunity in Mice Lacking CB1 and CB2 Receptors (Cnr1 (-/-) /Cnr2 (-/-) Mice) is not Due to Increased Splenic Noradrenergic Neuronal Activity. JOURNAL OF NEUROIMMUNE PHARMACOLOGY 9:544-557(2014).
Cecyre, B; Thomas, S; et al. Evaluation of the specificity of antibodies raised against cannabinoid receptor type 2 in the mouse retina. NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY 387:175-184(2014).
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