COL2A1
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Official Full Name
collagen, type II, alpha 1
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Overview
Type II collagen is the major collagen found in cartilage and is expressed in two forms: IIA and IIB. Type IIA procollagen contains an N-terminal 69 amino acid, cysteine-rich globular domain that is encoded by exon 2. Type IIB procollagen is synthesized by mature chondrocytes in cartilage while Type IIA procollagen is synthesized by chondroprogenitor cells. The Type IIA N-propeptide (PIIANP) has been postulated to play a role in chondrogensis. Type IIA procollagen has been found to be synthesized by osteoarthritic chondrocytes in diseased cartilage and may serve as a specific arthritis biomarker that reflects an attempt by the chondrocytes to repair diseased cartilage. -
Synonyms
ANFH; AOM; COL11A3; SEDC; alpha-1 type II collagen; cartilage collagen; chondrocalcin; collagen II, alpha-1 polypeptide; collagen alpha-1(II) chain; COL2A1;
- Recombinant Proteins
- Cell & Tissue Lysates
- Native Proteins
- Protein Pre-coupled Magnetic Beads
- Bovine
- Chicken
- Human
- Mouse
- Rabbit
- Rat
- Chick sternum
- CHO
- E.coli
- Fetal bovine articular cartilage
- HEK293
- Human Cell
- Human joint
- Human Nasal Septum
- In Vitro Cell Free System
- Mammalian Cell
- Wheat Germ
- GST
- His
- His (Fc)
- Avi
- His|GST
- N/A
- N
Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
---|---|---|---|---|---|---|
Human | COL2A1-26H | Active Recombinant Human COL2A1 protein, His-tagged | CHO | His | ||
Human | COL2A1-3929H | Recombinant Human COL2A1 protein(Asp1242-Leu1487), His-tagged | HEK293 | N-His | Asp1242-Leu1487 | |
Human | COL2A1-1649H | Recombinant Human COL2A1 Protein, GST-tagged | Wheat Germ | GST | ||
Human | COL2A1-11432H | Recombinant Human COL2A1, His-tagged | E.coli | His | C-288a.a. | |
Human | COL2A1-181H | Recombinant Human COL2A1 | Mammalian Cell | His | ||
Human | COL2A1-2063HCL | Recombinant Human COL2A1 cell lysate | Human Cell | N/A | ||
Human | COL2A1-2155H | Recombinant Human COL2A1 Protein, His-tagged | E.coli | N-His | Trp1337-Leu1487 | |
Human | COL2A1-1648H | Native Human COL2A1 Protein | Human Nasal Septum | N/A | ||
Human | COL2A1-2156H | Recombinant Human COL2A1 Protein, His-tagged | E.coli | N-His | Asp1242-Leu1487 | |
Human | COL2A1-2712H-B | Recombinant Human COL2A1 Protein Pre-coupled Magnetic Beads | HEK293 | |||
Human | COL2a1-1284H | Recombinant Human COL2a1 protein, His-tagged | E.coli | His | Gln26~Ala181 | |
Human | COL2A1-2712H | Recombinant Human COL2A1 Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi | ||
Human | COL2A1-1647H | Native Human COL2A1 Protein | Human joint | N/A | ||
Human | COL2A1-1763H | Recombinant Human COL2A1 Protein (Ser1386-Pro1467), N-His tagged | E.coli | N-His | Ser1386-Pro1467 | |
Human | COL2A1-2137HF | Recombinant Full Length Human COL2A1 Protein, GST-tagged | In Vitro Cell Free System | GST | 268 amino acids | |
Mouse | Col2a1-7924M | Recombinant Mouse Col2a1 protein, His-tagged | E.coli | His | Gly677~Ala817 (Accession # P28481) | |
Mouse | Col2a1-36M | Recombinant Mouse Col2a1 protein, His-tagged | HEK293 | His | ||
Mouse | COL2A1-3733M | Recombinant Mouse COL2A1 Protein | Mammalian Cell | His | ||
Mouse | Col2a1-1279M | Recombinant Mouse Col2a1 Protein, His-tagged | E.coli | N-His | Asp1242-Leu1487 | |
Mouse | COL2a1-3325M | Recombinant Mouse COL2a1 protein, His-GST-tagged | E.coli | His/GST | Gly677~Ala817 | |
Mouse | COL2A1-1861M | Recombinant Mouse COL2A1 Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi | ||
Mouse | COL2A1-1861M-B | Recombinant Mouse COL2A1 Protein Pre-coupled Magnetic Beads | HEK293 | |||
Rat | Col2a1-7925R | Recombinant Rat Col2a1 protein, His-tagged | E.coli | His | Lys1226~Tyr1331 (Accession # P05539) | |
Rat | COL2A1-1521R | Recombinant Rat COL2A1 Protein | Mammalian Cell | His | ||
Rat | COL2A1-1178R | Recombinant Rat COL2A1 Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi | ||
Rat | COL2A1-1178R-B | Recombinant Rat COL2A1 Protein Pre-coupled Magnetic Beads | HEK293 | |||
Rabbit | COL2A1-7926R | Recombinant Rabbit COL2A1 protein, His & GST-tagged | E.coli | His/GST | Leu1259~Val1449 | |
Bovine | COL2A1-13B | Native Bovine COL2A1 Protein | Fetal bovine articular cartilage | |||
Bovine | COL2A1-14B | Native Bovine COL2A1 Protein | Fetal bovine articular cartilage | |||
Chicken | COL2A1-5996C | Recombinant Chicken COL2A1 | Mammalian Cell | His | ||
Chicken | COL2A1-16C | Native Chicken COL2A1 Protein | Chick sternum | |||
Chicken | COL2A1-15C | Native Chicken COL2A1 Protein | Chick sternum |
- Involved Pathway
- Protein Function
- Interacting Protein
- COL2A1 Related Articles
- COL2A1 Related Research Area
COL2A1 involved in several pathways and played different roles in them. We selected most pathways COL2A1 participated on our site, such as Amoebiasis, Assembly of collagen fibrils and other multimeric structures, Collagen biosynthesis and modifying enzymes, which may be useful for your reference. Also, other proteins which involved in the same pathway with COL2A1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Amoebiasis | SERPINB3;C8G;COL3A1;COL1A1;COL5A1;LAMC3;IL-8;COL4A5;COL24A1 |
Assembly of collagen fibrils and other multimeric structures | COL1A2;CTSL2;CTSL1;LOX;COL4A3;COL10A1;BMP1B;COL6A3;COL4A4 |
Collagen biosynthesis and modifying enzymes | COL15A1B;LEPREL1;SERPINH1A;COL28A1;ADAMTS3;COL9A1A;COL5A1;LEPRE1;ADAMTS2 |
Collagen formation | PCOLCEA;COL17A1A;CRTAP;P3H2;LOXL3;COL9A1B;COL28A1;PRP;MMP20 |
ECM-receptor interaction | ITGB5;ITGB4;THBS3A;SV2C;LAMA3;COL6A4;COL6A3;COL27A1B;CD47 |
Endochondral Ossification | ADAMTS1;SOX9A;CST5;CTSL2;FRZB;PTH;NKX3-2;CDKN1C;DDR2 |
Extracellular matrix organization | MGC174155;ADAMTS4;F11R.2;MMP19;ELANE;DAG1;ABHD1;LEPREL1;TLL2 |
Focal Adhesion | RHOAD;PDPK1;RAF1B;PAK2A;VTNA;VEGFB;FYNB;RHOB;PARVA |
COL2A1 has several biochemical functions, for example, extracellular matrix structural constituent conferring tensile strength, identical protein binding, metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by COL2A1 itself. We selected most functions COL2A1 had, and list some proteins which have the same functions with COL2A1. You can find most of the proteins on our site.
Function | Related Protein |
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extracellular matrix structural constituent conferring tensile strength | COL9A1;COL9A3;COL2A1 |
identical protein binding | SERPINA1D;CBS;SERPINA1E;KDM6A;THG1L;SMURF2;DAPK3;PACSIN2;TRADD |
metal ion binding | CACNA2D2;PDE5A;BCL6A;ESR2B;CXXC1A;ZFP526;OVOL3;RPS6KAL;PPM1BB |
platelet-derived growth factor binding | COL1A1;COL6A1;PDGFB;PDGFRA;PDGFA;Pdgfa&Pdgfb;COL2A1;PDGFRB;COL1A2 |
COL2A1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with COL2A1 here. Most of them are supplied by our site. Hope this information will be useful for your research of COL2A1.
COCH; RELA; HYAL1
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