Creative BioMart to Present at
                        BIO-Europe Spring Creative BioMart to Present at BIO-Europe Spring|March 18–20, 2024|Booth #34

COL2A1

  • Official Full Name

    collagen, type II, alpha 1

  • Overview

    Type II collagen is the major collagen found in cartilage and is expressed in two forms: IIA and IIB. Type IIA procollagen contains an N-terminal 69 amino acid, cysteine-rich globular domain that is encoded by exon 2. Type IIB procollagen is synthesized by mature chondrocytes in cartilage while Type IIA procollagen is synthesized by chondroprogenitor cells. The Type IIA N-propeptide (PIIANP) has been postulated to play a role in chondrogensis. Type IIA procollagen has been found to be synthesized by osteoarthritic chondrocytes in diseased cartilage and may serve as a specific arthritis biomarker that reflects an attempt by the chondrocytes to repair diseased cartilage.
  • Synonyms

    ANFH; AOM; COL11A3; SEDC; alpha-1 type II collagen; cartilage collagen; chondrocalcin; collagen II, alpha-1 polypeptide; collagen alpha-1(II) chain; COL2A1;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Native Proteins
  • Protein Pre-coupled Magnetic Beads
  • Bovine
  • Chicken
  • Human
  • Mouse
  • Rabbit
  • Rat
  • Chick sternum
  • CHO
  • E.coli
  • Fetal bovine articular cartilage
  • HEK293
  • Human Cell
  • Human joint
  • Human Nasal Septum
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • His|GST
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human COL2A1-26H Active Recombinant Human COL2A1 protein, His-tagged CHO His
Human COL2A1-3929H Recombinant Human COL2A1 protein(Asp1242-Leu1487), His-tagged HEK293 N-His Asp1242-Leu1487
Human COL2A1-1649H Recombinant Human COL2A1 Protein, GST-tagged Wheat Germ GST
Human COL2A1-11432H Recombinant Human COL2A1, His-tagged E.coli His C-288a.a.
Human COL2A1-181H Recombinant Human COL2A1 Mammalian Cell His
Human COL2A1-2063HCL Recombinant Human COL2A1 cell lysate Human Cell N/A
Human COL2A1-2155H Recombinant Human COL2A1 Protein, His-tagged E.coli N-His Trp1337-Leu1487
Human COL2A1-1648H Native Human COL2A1 Protein Human Nasal Septum N/A
Human COL2A1-2156H Recombinant Human COL2A1 Protein, His-tagged E.coli N-His Asp1242-Leu1487
Human COL2A1-2712H-B Recombinant Human COL2A1 Protein Pre-coupled Magnetic Beads HEK293
Human COL2a1-1284H Recombinant Human COL2a1 protein, His-tagged E.coli His Gln26~Ala181
Human COL2A1-2712H Recombinant Human COL2A1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human COL2A1-1647H Native Human COL2A1 Protein Human joint N/A
Human COL2A1-1763H Recombinant Human COL2A1 Protein (Ser1386-Pro1467), N-His tagged E.coli N-His Ser1386-Pro1467
Human COL2A1-2137HF Recombinant Full Length Human COL2A1 Protein, GST-tagged In Vitro Cell Free System GST 268 amino acids
Mouse Col2a1-7924M Recombinant Mouse Col2a1 protein, His-tagged E.coli His Gly677~Ala817 (Accession # P28481)
Mouse Col2a1-36M Recombinant Mouse Col2a1 protein, His-tagged HEK293 His
Mouse COL2A1-3733M Recombinant Mouse COL2A1 Protein Mammalian Cell His
Mouse Col2a1-1279M Recombinant Mouse Col2a1 Protein, His-tagged E.coli N-His Asp1242-Leu1487
Mouse COL2a1-3325M Recombinant Mouse COL2a1 protein, His-GST-tagged E.coli His/GST Gly677~Ala817
Mouse COL2A1-1861M Recombinant Mouse COL2A1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse COL2A1-1861M-B Recombinant Mouse COL2A1 Protein Pre-coupled Magnetic Beads HEK293
Rat Col2a1-7925R Recombinant Rat Col2a1 protein, His-tagged E.coli His Lys1226~Tyr1331 (Accession # P05539)
Rat COL2A1-1521R Recombinant Rat COL2A1 Protein Mammalian Cell His
Rat COL2A1-1178R Recombinant Rat COL2A1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat COL2A1-1178R-B Recombinant Rat COL2A1 Protein Pre-coupled Magnetic Beads HEK293
Rabbit COL2A1-7926R Recombinant Rabbit COL2A1 protein, His & GST-tagged E.coli His/GST Leu1259~Val1449
Bovine COL2A1-13B Native Bovine COL2A1 Protein Fetal bovine articular cartilage
Bovine COL2A1-14B Native Bovine COL2A1 Protein Fetal bovine articular cartilage
Chicken COL2A1-5996C Recombinant Chicken COL2A1 Mammalian Cell His
Chicken COL2A1-16C Native Chicken COL2A1 Protein Chick sternum
Chicken COL2A1-15C Native Chicken COL2A1 Protein Chick sternum
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • COL2A1 Related Articles
  • COL2A1 Related Research Area

COL2A1 involved in several pathways and played different roles in them. We selected most pathways COL2A1 participated on our site, such as Amoebiasis, Assembly of collagen fibrils and other multimeric structures, Collagen biosynthesis and modifying enzymes, which may be useful for your reference. Also, other proteins which involved in the same pathway with COL2A1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
AmoebiasisIL12A;CD1d1;PIK3CG;LAMB2;SERPINB6B;CD1D;CTSG;LAMA2;LAMA5
Assembly of collagen fibrils and other multimeric structuresCOL6A1;COL4A5;CTSS;LOXL3;COL5A3A;LOXL2;COL1A2;COL4A4;COL8A1
Collagen biosynthesis and modifying enzymesCOL9A1A;COL25A1;COL13A1;PCOLCE2;ADAMTS2;TLDC2;TLL2;COL16A1;COL15A1B
Collagen formationPCOLCE2B;LEPREL1;COL4A6;ABHD1;SERPINH1B;COL6A1;COL3A1;ADAMTS2;COL6A3
ECM-receptor interactionITGA2B;GP6;COL4A4;COL5A2;TNC;LAMB4;VWF;ITGB1A;COL6A1
Endochondral OssificationPTHLH;CST5;IFT88;NKX3-2;CTSL2;SOX5;MGP;KIF3A;DDR2
Extracellular matrix organizationDAG1;MFAP4;COL3A1;COL23A1;LOXL2;TIMP2;LTBP3;COL17A1A;PRP
Focal AdhesionLAMA4;VCL;VEGFAA;DOCK1;LAMB2;MAP2K1;PPP1CAA;RAF1B;MAPK8

COL2A1 has several biochemical functions, for example, extracellular matrix structural constituent conferring tensile strength, identical protein binding, metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by COL2A1 itself. We selected most functions COL2A1 had, and list some proteins which have the same functions with COL2A1. You can find most of the proteins on our site.

Function Related Protein
extracellular matrix structural constituent conferring tensile strengthCOL9A3;COL2A1;COL9A1
identical protein bindingDYRK1A;IGF2R;GCC2;ATL2;B2M;MIEF1;KHDC1B;PYDC3;TRIM39
metal ion bindingPVALB6;PDE12;TRPM6;MYSM1;ATP1A1A.2;ZNF672;ZNF395A;KCNH7;RACGAP1
platelet-derived growth factor bindingCOL5A1;COL1A1;PDGFA;Pdgfa&Pdgfb;COL2A1;COL4A1;PDGFRA;COL1A2;COL6A1

COL2A1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with COL2A1 here. Most of them are supplied by our site. Hope this information will be useful for your research of COL2A1.

COCH; RELA; HYAL1

Tillgren, V; Ho, JCS; et al. The Novel Small Leucine-rich Protein Chondroadherin-like (CHADL) Is Expressed in Cartilage and Modulates Chondrocyte Differentiation. JOURNAL OF BIOLOGICAL CHEMISTRY 290:918-925(2015).
Li, J; Xie, ZG; et al. Calcitonin treatment is associated with less severe osteoarthritis and reduced toll-like receptor levels in a rat model. JOURNAL OF ORTHOPAEDIC SCIENCE 19:1019-1027(2014).
  • Q&As
  • Reviews

Q&As (0)

Ask a question

Customer Reviews (0)

Write a review

Ask a Question for All COL2A1 Products

Required fields are marked with *

My Review for All COL2A1 Products

Required fields are marked with *

logo

FOLLOW US

Terms and Conditions        Privacy Policy

Copyright © 2024 Creative BioMart. All Rights Reserved.

Contact Us

  • /

Stay Updated on the Latest Bioscience Trends