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COMMD1

  • Official Full Name

    copper metabolism (Murr1) domain containing 1

  • Overview

    COMMD1 is a regulator of copper homeostasis, sodium uptake, and NF-kappa-B (see MIM 164011) signaling (de Bie et al.,;2005 (PubMed 16267171)).
  • Synonyms

    COMMD1; copper metabolism (Murr1) domain containing 1; C2orf5, chromosome 2 open reading frame 5 (MURR1); COMM domain-containing protein 1; copper metabolism gene MURR1; MGC27155; MURR1; C2orf5; COMD1; COMD1_HUMAN; copper metabolism domain containing 1; Protein Murr1; OTTHUMP00000159817;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Human
  • Mouse
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • Myc
  • DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human COMMD1-28014TH Recombinant Human COMMD1, His-tagged E.coli His 190 amino acids
Human COMMD1-28013TH Recombinant Human COMMD1, His-tagged E.coli His 190 amino acids
Human COMMD1-1674H Recombinant Human COMMD1 Protein, GST-tagged Wheat Germ GST
Human COMMD1-2732H Recombinant Human COMMD1, His-tagged E.coli His
Human COMMD1-7373HCL Recombinant Human COMMD1 293 Cell Lysate HEK293 N/A
Human COMMD1-954H Recombinant Human COMMD1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human COMMD1-2213HF Recombinant Full Length Human COMMD1 Protein, GST-tagged In Vitro Cell Free System GST 190 amino acids
Human COMMD1-4633H Recombinant Human COMMD1 protein, GST-tagged E.coli GST 1-190aa
Mouse Commd1-2246M Recombinant Mouse Commd1 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Zebrafish COMMD1-4265Z Recombinant Zebrafish COMMD1 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • COMMD1 Related Articles
  • COMMD1 Related Research Area

COMMD1 involved in several pathways and played different roles in them. We selected most pathways COMMD1 participated on our site, such as TNF-alpha/NF-kB Signaling Pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with COMMD1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
TNF-alpha/NF-kB Signaling PathwayRNF216;AKAP8;SMARCE1;TRPC4AP;TANK;CAPN3;NKIRAS1;TRAIP;KPNA6

COMMD1 has several biochemical functions, for example, copper ion binding, identical protein binding, phosphatidic acid binding. Some of the functions are cooperated with other proteins, some of the functions could acted by COMMD1 itself. We selected most functions COMMD1 had, and list some proteins which have the same functions with COMMD1. You can find most of the proteins on our site.

Function Related Protein
copper ion bindingDBH;GPC1;METTL17;MT3;COMMD1;AOC3;ATP7B;MOXD1;LOXL3A
identical protein bindingUGP2;SERPINA1D;NFKB1;MAP3K11;FRS3;SIAH1A;APOH;DPP9;STK10
phosphatidic acid bindingSESTD1;PLCD1;JPH2;RAPGEF6;MAPKAP1;MICALL1;MARK1;COMMD1;PACSIN2
phosphatidylinositol-3,4,5-trisphosphate bindingGAB2;INPPL1;MYO1G;AKT1;CYTH3;MAPKAP1;PHLDA3;ADAP2;FAM21C
phosphatidylinositol-3,4-bisphosphate bindingDAPP1;FAM21C;D6WSU116E;KIF16B;ZFYVE1;MAPKAP1;ADAP2;COMMD1;TTPA
phosphatidylinositol-3,5-bisphosphate bindingWDR45L;WDR45;SNX14;WIPI1;JPH2;D6WSU116E;RAG2;SESTD1;KIF16B
phosphatidylinositol-4,5-bisphosphate bindingRPH3A;PHLDA3;PARD3;SNX20;SCIN;MAPKAP1;ADAP2;TWF2;PFN2
protein bindingPCK2;UBC;ZNF643;PARP9;METTL15;CYBRD1;REPS1;SPERT;CHMP2A
protein homodimerization activityNLGN4X;JUP;QPRT;CLN6;TDG;GDNF;CD247;FLT3;BMP2B

COMMD1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with COMMD1 here. Most of them are supplied by our site. Hope this information will be useful for your research of COMMD1.

COMMD6; CCDC22

Phillips-Krawczak, CA; Singla, A; et al. COMMD1 is linked to the WASH complex and regulates endosomal trafficking of the copper transporter ATP7A. MOLECULAR BIOLOGY OF THE CELL 26:91-103(2015).
Li, HY; Burstein, E; et al. COMMD1 regulates inflammation and colitis-associated cancer progression. ONCOIMMUNOLOGY 3:-(2014).
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