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COQ2

Official Full Name

coenzyme Q2 homolog, prenyltransferase (yeast)
Overview

This gene encodes an enzyme that functions in the final steps in the biosynthesis of CoQ (ubiquinone), a redox carrier in the mitochondrial respiratory chain and a lipid-soluble antioxidant. This enzyme, which is part of the coenzyme Q10 pathway, catalyzes the prenylation of parahydroxybenzoate with an all-trans polyprenyl group. Mutations in this gene cause coenzyme Q10 deficiency, a mitochondrial encephalomyopathy, and also COQ2 nephropathy, an inherited form of mitochondriopathy with primary renal involvement.
Synonyms

COQ2; coenzyme Q2 homolog, prenyltransferase (yeast); 4-hydroxybenzoate polyprenyltransferase, mitochondrial; 4 hydroxybenzoate polyprenyltransferase; CL640; FLJ26072; MGC91278; 2310002F18Rik; FLJ13014; hCOQ2; MGC124824; OTTMUSP00000032111; Para-hydroxybenzoate--polyprenyltransferase, mitochondrial; PHB:polyprenyltransferase; RGD1306722; COQ2 homolog; para-hydroxybenzoate-polyprenyltransferase, mitochondrial;

Type

Recombinant Proteins
Protein Pre-coupled Magnetic Beads

Species

Human
Mouse
Mus musculus (Mouse)
Rat
Zebrafish

Source

E.coli expression system
HEK293
In Vitro Cell Free System
Mammalian Cell
Wheat Germ

Tag

GST
His
His (Fc)
Avi

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	COQ2-1713H	Recombinant Human COQ2 Protein, GST-tagged	Wheat Germ	GST		Inquiry
Human	COQ2-1973HF	Recombinant Full Length Human COQ2 Protein, GST-tagged	In Vitro Cell Free System	GST	371 amino acids	Inquiry
Mouse	COQ2-3790M	Recombinant Mouse COQ2 Protein	Mammalian Cell	His		Inquiry
Mouse	COQ2-1897M	Recombinant Mouse COQ2 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Mouse	COQ2-1897M-B	Recombinant Mouse COQ2 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Rat	COQ2-1537R	Recombinant Rat COQ2 Protein	Mammalian Cell	His		Inquiry
Rat	COQ2-1194R	Recombinant Rat COQ2 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Rat	COQ2-1194R-B	Recombinant Rat COQ2 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Mus musculus (Mouse)	RFL5960MF	Recombinant Full Length Mouse 4-Hydroxybenzoate Polyprenyltransferase, Mitochondrial(Coq2) Protein, His-Tagged	E.coli expression system	His	Full Length of Mature Protein (35-374)	Inquiry
Zebrafish	COQ2-5589Z	Recombinant Zebrafish COQ2	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein
COQ2 Related Articles

COQ2 involved in several pathways and played different roles in them. We selected most pathways COQ2 participated on our site, such as Ubiquinone and other terpenoid-quinone biosynthesis, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with COQ2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Ubiquinone and other terpenoid-quinone biosynthesis	HPDA;VKORC1;VKORC1L1;COQ7;COQ2;COQ6;HPDB;AMOTL1;TAT
Metabolic pathways	ACSL3B;GALNTL4;POLD2;AANAT;GALCB;ALDH9A1B;ADKB;PLD1;DDOST

COQ2 has several biochemical functions, for example, 4-hydroxybenzoate decaprenyltransferase activity, 4-hydroxybenzoate nonaprenyltransferase activity, prenyltransferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by COQ2 itself. We selected most functions COQ2 had, and list some proteins which have the same functions with COQ2. You can find most of the proteins on our site.

Function	Related Protein
4-hydroxybenzoate decaprenyltransferase activity
4-hydroxybenzoate nonaprenyltransferase activity
prenyltransferase activity	UBIAD1;PTAR1;PGGT1B;COQ2
transferase activity	HS3ST1L1;FYNA;GSBP9;CHST2A;UGT1B7;CSNK1DB;MAPK14A;CAMK1DB;ILF2

COQ2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with COQ2 here. Most of them are supplied by our site. Hope this information will be useful for your research of COQ2.

Lin, CH; Lin, HI; et al. COQ2 p.V393A variant, rs148156462, is not associated with Parkinson's disease in a Taiwanese population. NEUROBIOLOGY OF AGING 36:-(2015).

Desbats, MA; Lunardi, G; et al. Genetic bases and clinical manifestations of coenzyme Q(10) (CoQ(10)) deficiency. JOURNAL OF INHERITED METABOLIC DISEASE 38:145-156(2015).