COX11
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Official Full Name
COX11 cytochrome c oxidase assembly homolog (yeast)
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Overview
Cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes a protein which is not a structural subunit, but may be a heme A biosynthetic enzyme involved in COX formation, according to the yeast mutant studies. However, the studies in Rhodobacter sphaeroides suggest that this gene is not required for heme A biosynthesis, but required for stable formation of the Cu(B) and magnesium centers of COX. This human protein is predicted to contain a transmembrane domain localized in the mitochondrial inner membrane. Multiple transcript variants encoding different isoforms have been found for this gene. A related pseudogene has been found on chromosome 6. -
Synonyms
COX11; COX11 cytochrome c oxidase assembly homolog (yeast); COX11 (yeast) homolog, cytochrome c oxidase assembly protein; cytochrome c oxidase assembly protein COX11, mitochondrial; COX11P; cytochrome c oxidase assembly protein COX11; cytochrome c oxidase subunit 11; COX11 homolog; COX11 homolog, cytochrome c oxidase assembly protein (yeast); COX11 homolog, cytochrome c oxidase assembly protein;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Arabidopsis thaliana (Mouse-ear cress)
- Human
- Mouse
- Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
- Rhesus Macaque
- Zebrafish
- E.coli expression system
- HEK293
- In Vitro Cell Free System
- Mammalian Cell
- Wheat Germ
- GST
- His
- His (Fc)
- Avi
- N/A
- Involved Pathway
- Protein Function
- Interacting Protein
COX11 involved in several pathways and played different roles in them. We selected most pathways COX11 participated on our site, such as Electron Transport Chain, Gene Expression, Generic Transcription Pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with COX11 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Electron Transport Chain | UCP2;COX6B1;COX17;UCP3;SLC25A14;NDUFS7;SCO1;NDUFC2-KCTD14;COX15 |
| Gene Expression | NFIX;MED23;ADARB1A;SNRNP35;TXN;ZNF664;EARS2;SUGP1;CTDP1 |
| Generic Transcription Pathway | NRBF2B;ZNF205;ZNF791;ZNF597;ZFP1;SESN3;ZNF192;ZFP2;LRPPRC |
| Metabolic pathways | GART;AGPAT3;SYNJ2;PC;GPAA1;MTMR1;HSD3B6;NADK2;IPMK |
| Metabolism | CEPT1;APOC2;PNPLA8;CYP4F11;ADSS;COX14;FABP12;CYP2F1;ELA2 |
| Oxidative phosphorylation | SDHA;NDUFB5;NDUFA5;ATP6V1G2;ATP6AP1;ATP6V0C;SDHDB;ATP6V1E2;COX8C |
| Respiratory electron transport | NDUFA11;TIMMDC1;ETFDH;NDUFAF7;SCO1;ETFB;NDUFAF3;NDUFAF2;C20orf7 |
| Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. | UCP2;COX14;TACO1;NDUFAF3;NDUFAF5;ETFA;NDUFAF4;SLC25A27;ATP5L |
COX11 has several biochemical functions, for example, copper ion binding, cytochrome-c oxidase activity, electron carrier activity. Some of the functions are cooperated with other proteins, some of the functions could acted by COX11 itself. We selected most functions COX11 had, and list some proteins which have the same functions with COX11. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| copper ion binding | PAM;PRNP;S100A5;TYRP1B;COMMD1;TYRP1;HEPHL1;POLR1B;PARK7 |
| cytochrome-c oxidase activity | COX7B;COX7C;COX11;COX5B2;COX7B2;COX5B;COX7A1;COA6;COX6A2 |
| electron carrier activity | COX7A1;AOX3;AOX1;POR;SDHC;SRD5A1;CYP19A1;GRXCR1;NDUFS2 |
COX11 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with COX11 here. Most of them are supplied by our site. Hope this information will be useful for your research of COX11.
SQSTM1; RPL19; Csk; Smn1; Cep44; Kctd5; Bag2; COA3
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