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CPN1

Official Full Name

carboxypeptidase N, polypeptide 1
Overview

Carboxypeptidase N is a plasma metallo-protease that cleaves basic amino acids from the C terminal of peptides and proteins. The enzyme is important in the regulation of peptides like kinins and anaphylatoxins, and has also been known as kininase-1 and anaphylatoxin inactivator. This enzyme is a tetramer comprised of two identical regulatory subunits and two identical catalytic subunits; this gene encodes the catalytic subunit. Mutations in this gene can be associated with angioedema or chronic urticaria resulting from carboxypeptidase N deficiency.
Synonyms

CPN1; carboxypeptidase N, polypeptide 1; carboxypeptidase N, polypeptide 1, 50kD; carboxypeptidase N catalytic chain; anaphylatoxin inactivator; arginine carboxypeptidase; carboxypeptidase K; kininase I; lysine carboxypeptidase; kininase-1; serum carboxyp;

Type

Recombinant Proteins
Cell & Tissue Lysates
Protein Pre-coupled Magnetic Beads

Species

Chicken
Human
Mouse
Rat
Zebrafish

Source

E.coli
HEK293
In Vitro Cell Free System
Mammalian Cell
Wheat Germ

Tag

GST
His
His (Fc)
Avi
Myc
His|GST
N/A
N

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	CPN1-847H	Recombinant Human CPN1 Protein, His-tagged	E.coli	His		Inquiry
Human	CPN1-1791H	Recombinant Human CPN1 Protein, GST-tagged	Wheat Germ	GST		Inquiry
Human	CPN1-7310HCL	Recombinant Human CPN1 293 Cell Lysate	HEK293	N/A		Inquiry
Human	CPN1-1796H	Recombinant Human CPN1 Protein (Leu159-Leu325), N-His tagged	E.coli	N-His	Leu159-Leu325	Inquiry
Human	CPN1-2723H	Recombinant Human CPN1 protein, His&Myc-tagged	E.coli	His&Myc	21-458aa	Inquiry
Human	CPN1-2097HF	Recombinant Full Length Human CPN1 Protein, GST-tagged	In Vitro Cell Free System	GST	458 amino acids	Inquiry
Mouse	Cpn1-1439M	Recombinant Mouse Cpn1 protein, His & GST-tagged	E.coli	His/GST	Val221~Ala449 (Accession # Q9JJN5)	Inquiry
Mouse	CPN1-3844M	Recombinant Mouse CPN1 Protein	Mammalian Cell	His		Inquiry
Mouse	CPN1-1931M-B	Recombinant Mouse CPN1 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Mouse	CPN1-1931M	Recombinant Mouse CPN1 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Rat	CPN1-1568R	Recombinant Rat CPN1 Protein	Mammalian Cell	His		Inquiry
Rat	CPN1-1225R-B	Recombinant Rat CPN1 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Rat	CPN1-1225R	Recombinant Rat CPN1 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Zebrafish	CPN1-12039Z	Recombinant Zebrafish CPN1	Mammalian Cell	His		Inquiry
Chicken	CPN1-4753C	Recombinant Chicken CPN1	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein

CPN1 involved in several pathways and played different roles in them. We selected most pathways CPN1 participated on our site, such as Insulin processing, Metabolism of proteins, Peptide hormone metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with CPN1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Insulin processing	PCSK1;SLC30A5;KIF5A;EXOC5;EXOC3;EXOC1;CPE;SLC30A8;SLC30A6
Metabolism of proteins	ODAM;PAPPA2;ARSD;TBCB;SLC35A1;SEC61B;NEU3;KCNA6;INHBAA
Peptide hormone metabolism	CGB5;MBOAT4;SLC38A8;ATP6AP2;GPR120;PCSK2;GZMH;SLC30A6;DPP4
Prostate Cancer	INS2;AKT1;PIK3R2;PIK3R1;HSP90B1;PIK3CA;INS;CREB3L1;LEF1
Steroid Biosynthesis	FDFT1;CELL;HSD17B7;SOAT2;MSMO1;LSS;TM7SF2;DHCR7;CEL.1

CPN1 has several biochemical functions, for example, metallocarboxypeptidase activity, serine-type carboxypeptidase activity, zinc ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CPN1 itself. We selected most functions CPN1 had, and list some proteins which have the same functions with CPN1. You can find most of the proteins on our site.

Function	Related Protein
metallocarboxypeptidase activity	AGBL4;AGBL5;CPA1;CPA2;AEBP1;CPA5;CPB2;CPO;AGBL2
serine-type carboxypeptidase activity	DPP7;SENP2;CPM;CPD;CPZ;CTSA;CPE;CPDB;CPN1
zinc ion binding	APOBEC2;ZDHHC18B;ZDHHC19;IFIH1;Adam6;ADAMTS15A;PAM;NR5A1;LHX1B

CPN1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CPN1 here. Most of them are supplied by our site. Hope this information will be useful for your research of CPN1.

CDC42; CLEC4G