CPSF4
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Official Full Name
cleavage and polyadenylation specific factor 4, 30kDa
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Overview
Inhibition of the nuclear export of poly(A)-containing mRNAs caused by the influenza A virus NS1 protein requires its effector domain. The NS1 effector domain functionally interacts with the cellular 30 kDa subunit of cleavage and polyadenylation specific factor 4, an essential component of the 3 end processing machinery of cellular pre-mRNAs. In influenza virus-infected cells, the NS1 protein is physically associated with cleavage and polyadenylation specific factor 4, 30kD subunit. Binding of the NS1 protein to the 30 kDa protein in vitro prevents CPSF binding to the RNA substrate and inhibits 3 end cleavage and polyadenylation of host pre-mRNAs. Thus the NS1 protein selectively inhibits the nuclear export of cellular, and not viral, mRNAs. Multiple alternatively spliced transcript variants that encode different isoforms have been described for this gene. -
Synonyms
CPSF4; cleavage and polyadenylation specific factor 4, 30kDa; cleavage and polyadenylation specific factor 4, 30kD subunit; cleavage and polyadenylation specificity factor subunit 4; CPSF30; NAR; Cleavage and polyadenylation specificity factor 30 kDa subunit; cleavage polyadenylation specificity factor, 30kD; CPSF 30 kDa subunit; CPSF4_HUMAN; Neb-1; NEB1; No arches homolog; no arches like zinc finger protein; NS1 effector domain binding protein 1; NS1 effector domain-binding protein 1; OTTHUMP00000206234; OTTHUMP00000206235; OTTHUMP00000206236; OTTHUMP00000206237; OTTHUMP00000206239; no arches-like zinc finger protein; NS1 effector domain-bin;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Chicken
- Human
- Mouse
- Rat
- Rhesus Macaque
- Zebrafish
- E.coli
- HEK293
- In Vitro Cell Free System
- Mammalian Cell
- Wheat Germ
- GST
- GST|His
- His
- His (Fc)
- Avi
- N/A
- Involved Pathway
- Protein Function
- Interacting Protein
CPSF4 involved in several pathways and played different roles in them. We selected most pathways CPSF4 participated on our site, such as Disease, Gene Expression, Host Interactions with Influenza Factors, which may be useful for your reference. Also, other proteins which involved in the same pathway with CPSF4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Disease | CUX1;SSRP1;RBP1;KPNA5;KPNA3;TNKS2;HEY1;HEYL;FMOD |
| Gene Expression | LSM6;C14orf166;TH1L;LSM10;NR4A2A;ZNF202;ZNF649;EHMT2;CRCP |
| Host Interactions with Influenza Factors | KPNA5;KPNA4;KPNA3;CPSF4 |
| Infectious disease | RCC1;CPSF4;AP1M2;EEF2;NMT2;KPNA4;PPIAL4A;DOCK2;SYT2 |
| Influenza A | STAT1;RAE1;TYK2;HLA-DOA;RAF1;TNFRSF10D;IKBKB;PRSS2;HLA-DMB |
| Influenza Infection | KPNA5;IPO5;KPNA3;KPNA4;CPSF4 |
| Inhibition of Host mRNA Processing and RNA Silencing | |
| NS1 Mediated Effects on Host Pathways |
CPSF4 has several biochemical functions, for example, poly(A) RNA binding, protein binding, zinc ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CPSF4 itself. We selected most functions CPSF4 had, and list some proteins which have the same functions with CPSF4. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| poly(A) RNA binding | NOVA1;RAN;PABPN1;CCT3;RBMS1;RPSA;PCBP1;SF3A1;MAGOH2 |
| protein binding | TPM4;RHOV;SSNA1;SRC;GPN3;OLIG1;MNDA;DMPK;SPI1 |
| zinc ion binding | ZFAND5;ANPEPB;TADA2B;VPS11;SYTL4;SP140;MARCH9;MAN2B2;PGLYRP3 |
CPSF4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CPSF4 here. Most of them are supplied by our site. Hope this information will be useful for your research of CPSF4.
MEOX2; 81608; FIP1L1; NS; MARK3; NPM1; CLK2; SNW1; SYMPK; TUT1; CPSF3
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