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CPT1A

  • Official Full Name

    carnitine palmitoyltransferase 1A (liver)

  • Overview

    The mitochondrial oxidation of long-chain fatty acids is initiated by the sequential action of carnitine palmitoyltransferase I (which is located in the outer membrane and is detergent-labile) and carnitine palmitoyltransferase II (which is located in the inner membrane and is detergent-stable), together with a carnitine-acylcarnitine translocase. CPT I is the key enzyme in the carnitine-dependent transport across the mitochondrial inner membrane and its deficiency results in a decreased rate of fatty acid beta-oxidation. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
  • Synonyms

    CPT1A; carnitine palmitoyltransferase 1A (liver); CPT1; carnitine O-palmitoyltransferase 1, liver isoform; CPT1 L; L CPT1; CPT I; CPTI-L; carnitine palmitoyltransferase I, liver; carnitine O-palmitoyltransferase I, liver isoform; CPT1-L; L-CPT1;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Equus caballus (Horse)
  • Homo sapiens (Human)
  • Human
  • Mouse
  • Mus musculus (Mouse)
  • Rat
  • Rattus norvegicus (Rat)
  • Zebrafish
  • E.coli
  • E.coli expression system
  • HEK293
  • HEK293T
  • Human Cell
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • DYKDDDDK
  • GST
  • His
  • His (Fc)
  • Avi
  • His|GST
  • Myc
  • DDK
  • MYC
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human CPT1A-26794TH Recombinant Human CPT1A Wheat Germ N/A 90 amino acids
Human CPT1A-1817H Recombinant Human CPT1A Protein, GST-tagged Wheat Germ GST
Human CPT1A-11541H Recombinant Human CPT1A, His-tagged E.coli His C-term-350a.a.
Human CPT1A-7300HCL Recombinant Human CPT1A 293 Cell Lysate HEK293 N/A
Human CPT1A-1185H Recombinant Human CPT1A protein, His-tagged E.coli His Arg191~Leu353
Human CPT1A-1798H Recombinant Human CPT1A Protein (Gln406-Thr745), N-His tagged E.coli N-His Gln406-Thr745
Human CPT1A-01H Recombinant Human CPT1A Protein, DYKDDDDK-tagged Human Cell DYKDDDDK
Human CPT1A-02H Recombinant Human CPT1A Protein, Myc/DDK-tagged HEK293T Myc/DDK
Human CPT1A-2228HF Recombinant Full Length Human CPT1A Protein, GST-tagged In Vitro Cell Free System GST 773 amino acids
Mouse Cpt1a-1453M Recombinant Mouse Cpt1a protein, His & GST-tagged E.coli His/GST Ala568~Lys773
Mouse CPT1A-3865M Recombinant Mouse CPT1A Protein Mammalian Cell His
Mouse Cpt1a-936M Recombinant Mouse Cpt1a Protein, MYC/DDK-tagged HEK293T MYC/DDK
Mouse CPT1A-1946M-B Recombinant Mouse CPT1A Protein Pre-coupled Magnetic Beads HEK293
Mouse CPT1A-1946M Recombinant Mouse CPT1A Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat CPT1A-1577R Recombinant Rat CPT1A Protein Mammalian Cell His
Rat Cpt1a-1454R Recombinant Rat Cpt1a protein, His & GST-tagged E.coli His/GST Leu572-Lys773 (Accession # P32198)
Rat CPT1A-1234R Recombinant Rat CPT1A Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat CPT1A-1234R-B Recombinant Rat CPT1A Protein Pre-coupled Magnetic Beads HEK293
Equus caballus (Horse) RFL27070EF Recombinant Full Length Horse Carnitine O-Palmitoyltransferase 1, Liver Isoform(Cpt1A) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (2-776)
Homo sapiens (Human) RFL5329HF Recombinant Full Length Human Carnitine O-Palmitoyltransferase 1, Liver Isoform(Cpt1A) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (2-773)
Mus musculus (Mouse) RFL10138MF Recombinant Full Length Mouse Carnitine O-Palmitoyltransferase 1, Liver Isoform(Cpt1A) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (2-773)
Rattus norvegicus (Rat) RFL23177RF Recombinant Full Length Rat Carnitine O-Palmitoyltransferase 1, Liver Isoform(Cpt1A) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (2-773)
Zebrafish CPT1A-3976Z Recombinant Zebrafish CPT1A Mammalian Cell His
Chicken CPT1A-2113C Recombinant Chicken CPT1A Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein

CPT1A involved in several pathways and played different roles in them. We selected most pathways CPT1A participated on our site, such as AMPK signaling, AMPK signaling pathway, Adipocytokine signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with CPT1A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
AMPK signalingELAVL1;ADRA1B;PPARGC1B;INS-IGF2;EEF2;CPT1B;CPT1A;ADRa1A;EIF4EBP1
AMPK signaling pathwayLEP;PRKAB2;CPT1B;PIK3CA;CPT1C;EEF2K;PRKAB1;IRS1;PRKAG2
Adipocytokine signaling pathwayPRKAB1B;POMCA;MAPK10;G6PC;PPARAB;IKBKB;NFKB1;NFKBIE;ACSL4B
Circadian ClockCRY1;RAI1;NRIP1;CRY2;DBP;NAMPT;CARM1;HELZ2;CSNK1E
FOXA2 and FOXA3 transcription factor networksCPT1A;CEBPA;KCNJ11;FOXA1;CPT1C;FOXF1;TTR;UCP2;CPT1B
Fatty Acid Beta OxidationCPT1A;CRAT;DECR1;CPT2;ECI1;SLC25A20;CHKB;CPT1B
Fatty acid degradationCPT1C;CYP4A14;CYP4A12A;HADHAB;ADH2-1;CYP4A10;ADH4;ACSL1A;ALDH3A2
Fatty acid metabolismFADS1;HSD17B12;ACACA;ACSL5;HSD17B12B;ACADS;ELOVL2;ACAA2;ACSBG1

CPT1A has several biochemical functions, for example, carnitine O-palmitoyltransferase activity, identical protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CPT1A itself. We selected most functions CPT1A had, and list some proteins which have the same functions with CPT1A. You can find most of the proteins on our site.

Function Related Protein
carnitine O-palmitoyltransferase activityCPT1A;CPT2;CPT1C;CPT1B
identical protein bindingRUVBL2;MUL1A;GRB2;ALDOB;TRIM21;TPCN2;ITGA2B;CEACAM16;VCP

CPT1A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CPT1A here. Most of them are supplied by our site. Hope this information will be useful for your research of CPT1A.

ESR2; CACYBP; CLIC1; HSPA5; CYBA; NR4A1; q81ye8_bacan; KBTBD7; leuD; carA; NPDC1; 15-deoxy-delta(12,14; ssrna_ug; E2F3

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