CPT1A
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Official Full Name
carnitine palmitoyltransferase 1A (liver)
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Overview
The mitochondrial oxidation of long-chain fatty acids is initiated by the sequential action of carnitine palmitoyltransferase I (which is located in the outer membrane and is detergent-labile) and carnitine palmitoyltransferase II (which is located in the inner membrane and is detergent-stable), together with a carnitine-acylcarnitine translocase. CPT I is the key enzyme in the carnitine-dependent transport across the mitochondrial inner membrane and its deficiency results in a decreased rate of fatty acid beta-oxidation. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. -
Synonyms
CPT1A; carnitine palmitoyltransferase 1A (liver); CPT1; carnitine O-palmitoyltransferase 1, liver isoform; CPT1 L; L CPT1; CPT I; CPTI-L; carnitine palmitoyltransferase I, liver; carnitine O-palmitoyltransferase I, liver isoform; CPT1-L; L-CPT1;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Chicken
- Equus caballus (Horse)
- Homo sapiens (Human)
- Human
- Mouse
- Mus musculus (Mouse)
- Rat
- Rattus norvegicus (Rat)
- Zebrafish
- E.coli
- E.coli expression system
- HEK293
- HEK293T
- Human Cell
- In Vitro Cell Free System
- Mammalian Cell
- Wheat Germ
- DYKDDDDK
- GST
- His
- His (Fc)
- Avi
- His|GST
- Myc
- DDK
- MYC
- N/A
- N
Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
---|---|---|---|---|---|---|
Human | CPT1A-26794TH | Recombinant Human CPT1A | Wheat Germ | N/A | 90 amino acids | |
Human | CPT1A-1817H | Recombinant Human CPT1A Protein, GST-tagged | Wheat Germ | GST | ||
Human | CPT1A-11541H | Recombinant Human CPT1A, His-tagged | E.coli | His | C-term-350a.a. | |
Human | CPT1A-7300HCL | Recombinant Human CPT1A 293 Cell Lysate | HEK293 | N/A | ||
Human | CPT1A-1185H | Recombinant Human CPT1A protein, His-tagged | E.coli | His | Arg191~Leu353 | |
Human | CPT1A-1798H | Recombinant Human CPT1A Protein (Gln406-Thr745), N-His tagged | E.coli | N-His | Gln406-Thr745 | |
Human | CPT1A-01H | Recombinant Human CPT1A Protein, DYKDDDDK-tagged | Human Cell | DYKDDDDK | ||
Human | CPT1A-02H | Recombinant Human CPT1A Protein, Myc/DDK-tagged | HEK293T | Myc/DDK | ||
Human | CPT1A-2228HF | Recombinant Full Length Human CPT1A Protein, GST-tagged | In Vitro Cell Free System | GST | 773 amino acids | |
Mouse | Cpt1a-1453M | Recombinant Mouse Cpt1a protein, His & GST-tagged | E.coli | His/GST | Ala568~Lys773 | |
Mouse | CPT1A-3865M | Recombinant Mouse CPT1A Protein | Mammalian Cell | His | ||
Mouse | Cpt1a-936M | Recombinant Mouse Cpt1a Protein, MYC/DDK-tagged | HEK293T | MYC/DDK | ||
Mouse | CPT1A-1946M-B | Recombinant Mouse CPT1A Protein Pre-coupled Magnetic Beads | HEK293 | |||
Mouse | CPT1A-1946M | Recombinant Mouse CPT1A Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi | ||
Rat | CPT1A-1577R | Recombinant Rat CPT1A Protein | Mammalian Cell | His | ||
Rat | Cpt1a-1454R | Recombinant Rat Cpt1a protein, His & GST-tagged | E.coli | His/GST | Leu572-Lys773 (Accession # P32198) | |
Rat | CPT1A-1234R | Recombinant Rat CPT1A Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi | ||
Rat | CPT1A-1234R-B | Recombinant Rat CPT1A Protein Pre-coupled Magnetic Beads | HEK293 | |||
Equus caballus (Horse) | RFL27070EF | Recombinant Full Length Horse Carnitine O-Palmitoyltransferase 1, Liver Isoform(Cpt1A) Protein, His-Tagged | E.coli expression system | His | Full Length of Mature Protein (2-776) | |
Homo sapiens (Human) | RFL5329HF | Recombinant Full Length Human Carnitine O-Palmitoyltransferase 1, Liver Isoform(Cpt1A) Protein, His-Tagged | E.coli expression system | His | Full Length of Mature Protein (2-773) | |
Mus musculus (Mouse) | RFL10138MF | Recombinant Full Length Mouse Carnitine O-Palmitoyltransferase 1, Liver Isoform(Cpt1A) Protein, His-Tagged | E.coli expression system | His | Full Length of Mature Protein (2-773) | |
Rattus norvegicus (Rat) | RFL23177RF | Recombinant Full Length Rat Carnitine O-Palmitoyltransferase 1, Liver Isoform(Cpt1A) Protein, His-Tagged | E.coli expression system | His | Full Length of Mature Protein (2-773) | |
Zebrafish | CPT1A-3976Z | Recombinant Zebrafish CPT1A | Mammalian Cell | His | ||
Chicken | CPT1A-2113C | Recombinant Chicken CPT1A | Mammalian Cell | His |
- Involved Pathway
- Protein Function
- Interacting Protein
CPT1A involved in several pathways and played different roles in them. We selected most pathways CPT1A participated on our site, such as AMPK signaling, AMPK signaling pathway, Adipocytokine signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with CPT1A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
---|---|
AMPK signaling | ELAVL1;ADRA1B;PPARGC1B;INS-IGF2;EEF2;CPT1B;CPT1A;ADRa1A;EIF4EBP1 |
AMPK signaling pathway | LEP;PRKAB2;CPT1B;PIK3CA;CPT1C;EEF2K;PRKAB1;IRS1;PRKAG2 |
Adipocytokine signaling pathway | PRKAB1B;POMCA;MAPK10;G6PC;PPARAB;IKBKB;NFKB1;NFKBIE;ACSL4B |
Circadian Clock | CRY1;RAI1;NRIP1;CRY2;DBP;NAMPT;CARM1;HELZ2;CSNK1E |
FOXA2 and FOXA3 transcription factor networks | CPT1A;CEBPA;KCNJ11;FOXA1;CPT1C;FOXF1;TTR;UCP2;CPT1B |
Fatty Acid Beta Oxidation | CPT1A;CRAT;DECR1;CPT2;ECI1;SLC25A20;CHKB;CPT1B |
Fatty acid degradation | CPT1C;CYP4A14;CYP4A12A;HADHAB;ADH2-1;CYP4A10;ADH4;ACSL1A;ALDH3A2 |
Fatty acid metabolism | FADS1;HSD17B12;ACACA;ACSL5;HSD17B12B;ACADS;ELOVL2;ACAA2;ACSBG1 |
CPT1A has several biochemical functions, for example, carnitine O-palmitoyltransferase activity, identical protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CPT1A itself. We selected most functions CPT1A had, and list some proteins which have the same functions with CPT1A. You can find most of the proteins on our site.
Function | Related Protein |
---|---|
carnitine O-palmitoyltransferase activity | CPT1A;CPT2;CPT1C;CPT1B |
identical protein binding | RUVBL2;MUL1A;GRB2;ALDOB;TRIM21;TPCN2;ITGA2B;CEACAM16;VCP |
CPT1A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CPT1A here. Most of them are supplied by our site. Hope this information will be useful for your research of CPT1A.
ESR2; CACYBP; CLIC1; HSPA5; CYBA; NR4A1; q81ye8_bacan; KBTBD7; leuD; carA; NPDC1; 15-deoxy-delta(12,14; ssrna_ug; E2F3
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