Creative BioMart to Present at AACR Annual Meeting|Apr. 5-10, 2024|Booth #2953 Learn More

CPZ

Official Full Name

carboxypeptidase Z
Overview

Chlorpromazine (as chlorpromazine hydrochloride, abbreviated CPZ) is a typical antipsychotic. Chlorpromazine works on a variety of receptors in the central nervous system, producing anticholinergic, antidopaminergic, antihistaminic, and weak antiadrenergic effects. Both the clinical indications and side effect profile of CPZ are determined by this broad action: its anticholinergic properties cause constipation, sedation, and hypotension, and help relieve nausea. It also has anxiolytic (anxiety-relieving) properties. Its antidopaminergic properties can cause extrapyramidal symptoms such as akathisia (restlessness, aka the 'largactil shuffle' where the patient walks almost constantly, despite having nowhere to go due to mandatory confinement, and takes small, shuffling steps) and dystonia. It is known to cause tardive dyskinesia, which can be irreversible.
Synonyms

CPZ; carboxypeptidase Z; metallocarboxypeptidase Z; MGC99682;

Type

Recombinant Proteins
Cell & Tissue Lysates
Protein Pre-coupled Magnetic Beads

Species

Chicken
Human
Rat

Source

E.coli
HEK293
Mammalian Cell

Tag

His
His (Fc)
Avi
N/A
N

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	CPZ-11548H	Recombinant Human CPZ, His-tagged	E.coli	His	303-652a.a.	$319 / 25ug
Human	CPZ-7296HCL	Recombinant Human CPZ 293 Cell Lysate	HEK293	N/A		Inquiry
Human	CPZ-2251H	Recombinant Human CPZ Protein (Met425-Tyr652), N-His tagged	E.coli	N-His	Met425-Tyr652	Inquiry
Rat	CPZ-1581R	Recombinant Rat CPZ Protein	Mammalian Cell	His		Inquiry
Rat	CPZ-1238R	Recombinant Rat CPZ Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Rat	CPZ-1238R-B	Recombinant Rat CPZ Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Chicken	CPZ-6147C	Recombinant Chicken CPZ	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein
CPZ Related Articles

CPZ involved in several pathways and played different roles in them. We selected most pathways CPZ participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with CPZ were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein

CPZ has several biochemical functions, for example, metallocarboxypeptidase activity, serine-type carboxypeptidase activity, zinc ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CPZ itself. We selected most functions CPZ had, and list some proteins which have the same functions with CPZ. You can find most of the proteins on our site.

Function	Related Protein
metallocarboxypeptidase activity	AGBL1;AGTPBP1;FOLH1;CPB1;CPB2;AGBL4;AGBL5;CPA2;CPM
serine-type carboxypeptidase activity	CPD;PRCP;DPP7;CPN1;CPE;CTSA;CPDB;CPM;SENP2
zinc ion binding	SIAH1A;PDLIM5;NR3C1;MT1F;CHD4;CPA4;TRAF1;TRIM22;BBOX1

CPZ has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CPZ here. Most of them are supplied by our site. Hope this information will be useful for your research of CPZ.

Yamasaki, T; Suzuki, A; et al. Comparison of the Anti-Prion Mechanism of Four Different Anti-Prion Compounds, Anti-PrP Monoclonal Antibody 44B1, Pentosan Polysulfate, Chlorpromazine, and U18666A, in Prion-Infected Mouse Neuroblastoma Cells. PLOS ONE 9:-(2014).

Xu, HY; Yang, HJ; et al. Differential effects of antipsychotics on the development of rat oligodendrocyte precursor cells exposed to cuprizone. EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE 264:121-129(2014).