CR2
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Official Full Name
complement component (3d/Epstein Barr virus) receptor 2
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Overview
CD21 is a 145 kD transmembrane protein, also known as complement C3d receptor (C3dR), complement receptor 2 (CR2), and Epstein-Barr virus receptor. CD21 is expressed on B cells, follicular dendritic cells, subsets of normal thymocytes and T cells, and som -
Synonyms
CR2; complement component (3d/Epstein Barr virus) receptor 2; complement receptor type 2; CD21; EBV receptor; complement C3d receptor; epstein-Barr virus receptor; CR; C3DR; SLEB9;
- Recombinant Proteins
- Cell & Tissue Lysates
- Others
- Human
- Mouse
- Rat
- E.coli
- HEK293
- HEK293T
- Human Cell
- Mammalian cells
- Yeast
- C
- 6×His
- His
- His|GST
- His|T7
- Myc
- DDK
- MYC
- Myc|DDK
- N/A
- N
- GST
- Strep II
| Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| Human | CR2-283H | Recombinant Human CR2, StrepII-tagged | Human Cell | Strep II | 21-347, 327 a.a. |
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| Human | CR2-836H | Recombinant Human CR2 protein, His & GST-tagged | E.coli | His/GST | Lys729~Ser957 (Accession # P20023) |
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| Human | CR2-237H | Recombinant Human CR2, StrepII-tagged | Human Cell | Strep II | 596-971, 376 a.a. |
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| Human | CR2-3186H | Active Recombinant Human CR2 protein(Met1-Arg971), His-tagged | HEK293 | C-His | Met1-Arg971 |
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| Human | CR2-2201HCL | Recombinant Human CR2 cell lysate | Human Cell | N/A |
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| Human | CR2-34H | Recombinant Human CR2 Protein (21-1035, Ectodomain), C-6×His tagged | HEK293 | C-6×His | 21-1035 |
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| Human | CR2-3258H | Recombinant Human CR2 protein, His-tagged | HEK293 | His | Phe28~Met248 |
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| Human | CR2-3334H | Recombinant Human CR2 Protein, MYC/DDK-tagged | HEK293 | Myc/DDK |
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| Human | CR2-2210H | Recombinant Human CR2 Protein, Myc/DDK-tagged, C13 and N15-labeled | HEK293T | Myc/DDK |
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| Human | CR2-4019H | Recombinant Human CR2 Protein (Met1-Arg971), C-His tagged | Mammalian cells | C-His | Met1-Arg971 |
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| Human | CDA083P | Recombinant Human CD-21 Protein | E.coli | N/A |
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| Human | CR2-1059H | Recombinant Human CR2 Protein (Lys729-Asp958), N-GST tagged | E.coli | N-GST | Lys729-Asp958 |
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| Mouse | Cr2-837M | Recombinant Mouse Cr2 protein, His & T7-tagged | E.coli | His/T7 | Cys463~Asp665 (Accession # P19070) |
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| Mouse | Cr2-5383M | Recombinant Mouse Cr2 protein, His-tagged | Yeast | His | 729-963aa |
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| Mouse | Cr2-938M | Recombinant Mouse Cr2 Protein, MYC/DDK-tagged | HEK293T | MYC/DDK |
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| Mouse | Cr2-2727M | Recombinant Mouse Cr2 protein, His-tagged | E.coli | His | 729-963aa |
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| Mouse | Cr2-2729M | Recombinant Mouse Cr2 protein, His-tagged | E.coli | His | 12-145aa |
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| Mouse | Cr2-2728M | Recombinant Mouse Cr2 protein, His-tagged | E.coli | His | 12-140aa |
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| Mouse | Cr2-5002M | Recombinant Mouse Cr2 protein, His-tagged | HEK293 | His | 12-145aa |
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| Rat | Cr2-838R | Recombinant Rat Cr2 protein, His & T7-tagged | E.coli | His/T7 | Gly571~Gly770 (Accession # D3Z9F7) |
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- Involved Pathway
- Protein Function
- Interacting Protein
- CR2 Related Articles
- CR2 Related Gene Family
- CR2 Related Research Area
CR2 involved in several pathways and played different roles in them. We selected most pathways CR2 participated on our site, such as B Cell Receptor Signaling Pathway, Complement and Coagulation Cascades, Epstein-Barr virus infection, which may be useful for your reference. Also, other proteins which involved in the same pathway with CR2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| B Cell Receptor Signaling Pathway | CD81;CMTM3;PDPK1A;PPP3CC;RAC2;STAP1;PTPN18;PIK3CG;NRAS |
| Complement and Coagulation Cascades | Serpina1b;SERPINA1A;C1R;LOC100514666;CFD;F3;F7;SERPIND1;KNG1 |
| Epstein-Barr virus infection | HLA-DQB1;SYK;CSNK2B;NEDD4;PSMC6;POLR2D;PSMD3;SKP2;POLR3E |
| Hematopoietic cell lineage | IL7;CSF1R;FCGR1A;CSF3R;FCER2;ITGA2;IL4;CD9;CD1D |
CR2 has several biochemical functions, for example, DNA binding, complement binding, complement receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CR2 itself. We selected most functions CR2 had, and list some proteins which have the same functions with CR2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| DNA binding | IRF7;ZBTB16A;CSDE1;LEMD3;CSDC2A;ZNF688;SERPINA3;HIST1H110;POU2F1A |
| complement binding | CD46;C8G;CR2;C8A;CFB;CD59 |
| complement receptor activity | |
| protein homodimerization activity | SLK;HARS2;KCNK9;RASGRP1;SLC16A1;PVRL2L;PVRL1B;ANO6;NRF1 |
| transmembrane signaling receptor activity | SIGLEC8;CD5;GPR98;LGR5;OR2A4;LGR6;TLR2;FCAMR;SEMA4D |
| virus receptor activity | ITGB6;HSPA1A;SIVA1;PVRL2;CLEC4M;ITGA2;TFRC;SLC52A2;ITGB5 |
CR2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CR2 here. Most of them are supplied by our site. Hope this information will be useful for your research of CR2.
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- Q&As
- Reviews
Q&As (7)
Ask a questionTherapeutically targeting CR2 could adjust immune responses in autoimmune conditions and transplantations.
CR2's interaction with complement pathways influences both innate and adaptive immunity, affecting phagocytosis and inflammation.
Genetic variations in CR2 can alter its function, affecting susceptibility to infections and autoimmunity.
CR2 is integral in B-cell activation and maturation, influencing adaptive immunity.
Changes in CR2 expression can affect immune self-tolerance, contributing to autoimmune diseases.
Cytokines and immune cell activation states regulate CR2 expression, impacting immune responses.
CR2 facilitates B-cell activation and antigen presentation by binding to complement component C3d, enhancing antibody responses.
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